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Body composition and basal metabolic rate in Hidradenitis Suppurativa: a Danish population-based and hospital-based cross-sectional study.

Abstract

BACKGROUND

Several studies have suggested an association between Hidradenitis Suppurativa (HS) and obesity. Obesity is often expressed as Body Mass Index (BMI). However, BMI lacks information on body composition. General obesity is a predictor of health status and cardiovascular risk, but body composition (e.g. abdominal fat) may be more so. Basal metabolic rate (BMR) is an expression of resting metabolism and may serve as a complementary tool when assessing the possibly underlying metabolism behind a persons' body composition.

OBJECTIVE

To investigate the body composition and basal metabolic rate in individuals with HS compared with healthy controls.

METHODS

We performed a cross-sectional study on both a hospital-based and population-based HS group and compared with controls using Bioelectrical Impedance Analysis to assess body composition.

RESULTS

We identified a hospital-based HS group of 32 hospital HS patients, a population-based HS group of 430 population HS patients, and 20 780 controls. Age- and sex-adjusted analyses showed a 10.12% (P < 0.0001) significantly higher fat percentage in the hospital-based HS group and 3.11% (P < 0.0001) significantly higher fat percentage for the population-based HS group compared to controls. Correspondingly, the HS groups had a lower muscle percentage (P < 0.0001) and lower bone mass percentage (P < 0.0001). Furthermore, visceral fat rating (P < 0.0001), Body Mass Index (P < 0.0001), waist circumference (P < 0.0001), and Waist/Hip Ratio (P < 0.0001) was significantly higher in HS patients compared with controls. Additionally, age and sex-adjusted analyses showed a higher predicted estimate of BMR for the HS groups compared with controls (154.56 kcal/day (95% CI 54.96-254.16) (P = 0.0031) for the hospital-based HS group, and 82.63 kcal/day (95%CI 59.70-105.56) (P < 0.0001) for the population-based HS group).

CONCLUSION

Hidradenitis Suppurativa is associated with a high fat percentage, high visceral fat, and low muscle percentage adding to the morbidity of HS. The higher predicted estimate of basal metabolic rate (BMR) in HS patients may reflect a dysfunctional metabolism contributing to the high-fat-body composition.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, Roskilde Hospital, Roskilde, Denmark.

    ,

    Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

    ,

    Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

    ,

    Sports Science and Psychology, VUC&hf Nordjylland, Aalborg, Denmark.

    ,

    Department of Dermatology, Roskilde Hospital, Roskilde, Denmark.

    ,

    Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Research, Nykøbing Falster Hospital, Nykøbing Falster, Denmark.

    Department of Dermatology, Roskilde Hospital, Roskilde, Denmark. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

    Source

    MeSH

    Adult
    Body Composition
    Cross-Sectional Studies
    Denmark
    Female
    Hidradenitis Suppurativa
    Humans
    Male
    Middle Aged
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26660945

    Citation

    Miller, I M., et al. "Body Composition and Basal Metabolic Rate in Hidradenitis Suppurativa: a Danish Population-based and Hospital-based Cross-sectional Study." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 30, no. 6, 2016, pp. 980-8.
    Miller IM, Rytgaard H, Mogensen UB, et al. Body composition and basal metabolic rate in Hidradenitis Suppurativa: a Danish population-based and hospital-based cross-sectional study. J Eur Acad Dermatol Venereol. 2016;30(6):980-8.
    Miller, I. M., Rytgaard, H., Mogensen, U. B., Miller, E., Ring, H. C., Ellervik, C., & Jemec, G. B. (2016). Body composition and basal metabolic rate in Hidradenitis Suppurativa: a Danish population-based and hospital-based cross-sectional study. Journal of the European Academy of Dermatology and Venereology : JEADV, 30(6), pp. 980-8. doi:10.1111/jdv.13522.
    Miller IM, et al. Body Composition and Basal Metabolic Rate in Hidradenitis Suppurativa: a Danish Population-based and Hospital-based Cross-sectional Study. J Eur Acad Dermatol Venereol. 2016;30(6):980-8. PubMed PMID: 26660945.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body composition and basal metabolic rate in Hidradenitis Suppurativa: a Danish population-based and hospital-based cross-sectional study. AU - Miller,I M, AU - Rytgaard,H, AU - Mogensen,U B, AU - Miller,E, AU - Ring,H C, AU - Ellervik,C, AU - Jemec,G B, Y1 - 2015/12/09/ PY - 2015/09/22/received PY - 2015/10/13/accepted PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2017/4/27/medline SP - 980 EP - 8 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 30 IS - 6 N2 - BACKGROUND: Several studies have suggested an association between Hidradenitis Suppurativa (HS) and obesity. Obesity is often expressed as Body Mass Index (BMI). However, BMI lacks information on body composition. General obesity is a predictor of health status and cardiovascular risk, but body composition (e.g. abdominal fat) may be more so. Basal metabolic rate (BMR) is an expression of resting metabolism and may serve as a complementary tool when assessing the possibly underlying metabolism behind a persons' body composition. OBJECTIVE: To investigate the body composition and basal metabolic rate in individuals with HS compared with healthy controls. METHODS: We performed a cross-sectional study on both a hospital-based and population-based HS group and compared with controls using Bioelectrical Impedance Analysis to assess body composition. RESULTS: We identified a hospital-based HS group of 32 hospital HS patients, a population-based HS group of 430 population HS patients, and 20 780 controls. Age- and sex-adjusted analyses showed a 10.12% (P < 0.0001) significantly higher fat percentage in the hospital-based HS group and 3.11% (P < 0.0001) significantly higher fat percentage for the population-based HS group compared to controls. Correspondingly, the HS groups had a lower muscle percentage (P < 0.0001) and lower bone mass percentage (P < 0.0001). Furthermore, visceral fat rating (P < 0.0001), Body Mass Index (P < 0.0001), waist circumference (P < 0.0001), and Waist/Hip Ratio (P < 0.0001) was significantly higher in HS patients compared with controls. Additionally, age and sex-adjusted analyses showed a higher predicted estimate of BMR for the HS groups compared with controls (154.56 kcal/day (95% CI 54.96-254.16) (P = 0.0031) for the hospital-based HS group, and 82.63 kcal/day (95%CI 59.70-105.56) (P < 0.0001) for the population-based HS group). CONCLUSION: Hidradenitis Suppurativa is associated with a high fat percentage, high visceral fat, and low muscle percentage adding to the morbidity of HS. The higher predicted estimate of basal metabolic rate (BMR) in HS patients may reflect a dysfunctional metabolism contributing to the high-fat-body composition. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/26660945/Body_composition_and_basal_metabolic_rate_in_Hidradenitis_Suppurativa:_a_Danish_population_based_and_hospital_based_cross_sectional_study_ L2 - https://doi.org/10.1111/jdv.13522 DB - PRIME DP - Unbound Medicine ER -