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microRNAs and Neurodegenerative Diseases.
Adv Exp Med Biol. 2015; 888:85-105.AE

Abstract

microRNAs (miRNAs) are small, noncoding RNA molecules that through imperfect base-pairing with complementary sequences of target mRNA molecules, typically cleave target mRNA, causing subsequent degradation or translation inhibition. Although an increasing number of studies have identified misregulated miRNAs in the neurodegenerative diseases (NDDs) Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, which suggests that alterations in the miRNA regulatory pathway could contribute to disease pathogenesis, the molecular mechanisms underlying the pathological implications of misregulated miRNA expression and the regulation of the key genes involved in NDDs remain largely unknown. In this chapter, we provide evidence of the function and regulation of miRNAs and their association with the neurological events in NDDs. This will help improve our understanding of how miRNAs govern the biological functions of key pathogenic genes in these diseases, which potentially regulate several pathways involved in the progression of neurodegeneration. Additionally, given the growing interest in the therapeutic potential of miRNAs, we discuss current clinical challenges to developing miRNA-based therapeutics for NDDs.

Authors+Show Affiliations

Neural Stem Cell Research Lab, Department of Research, National Neuroscience Institute, Singapore, 308433, Singapore.Department of Neurology, National Neuroscience Institute, SGH Campus, Singapore, 169856, Singapore. Department of Research, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore. Neuroscience and Behavioral Disorders program, Duke-National University of Singapore, Graduate Medical School, Singapore, 169857, Singapore.Neural Stem Cell Research Lab, Department of Research, National Neuroscience Institute, Singapore, 308433, Singapore. Li_ZENG@nni.com.sg. Department of Research, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore. Li_ZENG@nni.com.sg. Neuroscience and Behavioral Disorders program, Duke-National University of Singapore, Graduate Medical School, Singapore, 169857, Singapore. Li_ZENG@nni.com.sg.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26663180

Citation

Qiu, Lifeng, et al. "MicroRNAs and Neurodegenerative Diseases." Advances in Experimental Medicine and Biology, vol. 888, 2015, pp. 85-105.
Qiu L, Tan EK, Zeng L. MicroRNAs and Neurodegenerative Diseases. Adv Exp Med Biol. 2015;888:85-105.
Qiu, L., Tan, E. K., & Zeng, L. (2015). MicroRNAs and Neurodegenerative Diseases. Advances in Experimental Medicine and Biology, 888, 85-105. https://doi.org/10.1007/978-3-319-22671-2_6
Qiu L, Tan EK, Zeng L. MicroRNAs and Neurodegenerative Diseases. Adv Exp Med Biol. 2015;888:85-105. PubMed PMID: 26663180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - microRNAs and Neurodegenerative Diseases. AU - Qiu,Lifeng, AU - Tan,Eng King, AU - Zeng,Li, PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2016/5/20/medline KW - ALS KW - Alzheimer’s disease KW - Amyotrophic lateral sclerosis KW - Gehrig KW - Huntington’s disease KW - NDD KW - Neurodegenerative diseases KW - Parkinson’s disease KW - microRNAs SP - 85 EP - 105 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 888 N2 - microRNAs (miRNAs) are small, noncoding RNA molecules that through imperfect base-pairing with complementary sequences of target mRNA molecules, typically cleave target mRNA, causing subsequent degradation or translation inhibition. Although an increasing number of studies have identified misregulated miRNAs in the neurodegenerative diseases (NDDs) Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, which suggests that alterations in the miRNA regulatory pathway could contribute to disease pathogenesis, the molecular mechanisms underlying the pathological implications of misregulated miRNA expression and the regulation of the key genes involved in NDDs remain largely unknown. In this chapter, we provide evidence of the function and regulation of miRNAs and their association with the neurological events in NDDs. This will help improve our understanding of how miRNAs govern the biological functions of key pathogenic genes in these diseases, which potentially regulate several pathways involved in the progression of neurodegeneration. Additionally, given the growing interest in the therapeutic potential of miRNAs, we discuss current clinical challenges to developing miRNA-based therapeutics for NDDs. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/26663180/microRNAs_and_Neurodegenerative_Diseases_ L2 - https://dx.doi.org/10.1007/978-3-319-22671-2_6 DB - PRIME DP - Unbound Medicine ER -