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[Necrobiotic xanthogranuloma in paraproteinemia].
Hautarzt. 1989 Jun; 40(6):358-63.H

Abstract

Necrobiotic xanthogranuloma is a rare generalized dermatosis occurring exclusively in association with paraproteinemia. Clinically it is characterized by large, ulcerating, nodular and plaque-like tumors of the dermis and subcutis. Histologically the lesions are composed of a nonspecific, lymphocytic and plasmacellular infiltrate and highly characteristic granulomas with giant cells of the Touton and foreign body type. Ultrastructurally, tubular cystic organelles with a central lamella and a few ribosomes at their outer membranes are found. By means of histochemical studies we excluded the skin infiltrates as the site of the paraprotein release. The pathogenesis of the disease remains unclear; it is suggested that the paraprotein has functional features of a lipoprotein, which may bind to lipoprotein receptors of the histiocytes, thereby inducing xanthoma formation.

Authors+Show Affiliations

I. Universitäts-Hautklinik Wien.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

2666345

Citation

Rappersberger, K, et al. "[Necrobiotic Xanthogranuloma in Paraproteinemia]." Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, vol. 40, no. 6, 1989, pp. 358-63.
Rappersberger K, Wrba F, Heinz R, et al. [Necrobiotic xanthogranuloma in paraproteinemia]. Hautarzt. 1989;40(6):358-63.
Rappersberger, K., Wrba, F., Heinz, R., Zonzits, E., & Hönigsmann, H. (1989). [Necrobiotic xanthogranuloma in paraproteinemia]. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, 40(6), 358-63.
Rappersberger K, et al. [Necrobiotic Xanthogranuloma in Paraproteinemia]. Hautarzt. 1989;40(6):358-63. PubMed PMID: 2666345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Necrobiotic xanthogranuloma in paraproteinemia]. AU - Rappersberger,K, AU - Wrba,F, AU - Heinz,R, AU - Zonzits,E, AU - Hönigsmann,H, PY - 1989/6/1/pubmed PY - 1989/6/1/medline PY - 1989/6/1/entrez SP - 358 EP - 63 JF - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete JO - Hautarzt VL - 40 IS - 6 N2 - Necrobiotic xanthogranuloma is a rare generalized dermatosis occurring exclusively in association with paraproteinemia. Clinically it is characterized by large, ulcerating, nodular and plaque-like tumors of the dermis and subcutis. Histologically the lesions are composed of a nonspecific, lymphocytic and plasmacellular infiltrate and highly characteristic granulomas with giant cells of the Touton and foreign body type. Ultrastructurally, tubular cystic organelles with a central lamella and a few ribosomes at their outer membranes are found. By means of histochemical studies we excluded the skin infiltrates as the site of the paraprotein release. The pathogenesis of the disease remains unclear; it is suggested that the paraprotein has functional features of a lipoprotein, which may bind to lipoprotein receptors of the histiocytes, thereby inducing xanthoma formation. SN - 0017-8470 UR - https://www.unboundmedicine.com/medline/citation/2666345/[Necrobiotic_xanthogranuloma_in_paraproteinemia]_ L2 - http://www.diseaseinfosearch.org/result/7560 DB - PRIME DP - Unbound Medicine ER -