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Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat.
Allergol Int 2016; 65(1):16-20AI

Abstract

IgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen is important for facilitating both education and allergen avoidance that are essential to long-term risk reduction. As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation and management of patients with idiopathic anaphylaxis. Within the last 10 years several apparently separate observations were recognized to be related, all of which resulted from the development of antibodies to a carbohydrate moiety on proteins. Interestingly, the exposure differed from airborne allergens but was nevertheless capable of producing anaphylactic and hypersensitivity reactions. Our recent work has identified these responses as being due to a novel IgE antibody directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose ("alpha-gal"). This review will present the historical summary of the identification of cetuximab hypersensitivity due to alpha-gal IgE and discuss the non-primate mammalian meat food allergy as well as current goals and directions of our research programs.

Authors+Show Affiliations

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA. Electronic address: scommins@email.unc.edu.Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USA.Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USA; Carter Immunology Center, University of Virginia Health System, Charlottesville, VA, USA.Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USA; Carter Immunology Center, University of Virginia Health System, Charlottesville, VA, USA; Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

26666477

Citation

Commins, Scott P., et al. "Delayed Anaphylaxis to Alpha-gal, an Oligosaccharide in Mammalian Meat." Allergology International : Official Journal of the Japanese Society of Allergology, vol. 65, no. 1, 2016, pp. 16-20.
Commins SP, Jerath MR, Cox K, et al. Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat. Allergol Int. 2016;65(1):16-20.
Commins, S. P., Jerath, M. R., Cox, K., Erickson, L. D., & Platts-Mills, T. (2016). Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat. Allergology International : Official Journal of the Japanese Society of Allergology, 65(1), pp. 16-20. doi:10.1016/j.alit.2015.10.001.
Commins SP, et al. Delayed Anaphylaxis to Alpha-gal, an Oligosaccharide in Mammalian Meat. Allergol Int. 2016;65(1):16-20. PubMed PMID: 26666477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat. AU - Commins,Scott P, AU - Jerath,Maya R, AU - Cox,Kelly, AU - Erickson,Loren D, AU - Platts-Mills,Thomas, Y1 - 2015/11/21/ PY - 2015/10/09/received PY - 2015/10/21/accepted PY - 2015/12/16/entrez PY - 2015/12/17/pubmed PY - 2016/10/14/medline KW - Alpha-gal KW - Delayed anaphylaxis KW - Glycan KW - IgE KW - Red meat allergy SP - 16 EP - 20 JF - Allergology international : official journal of the Japanese Society of Allergology JO - Allergol Int VL - 65 IS - 1 N2 - IgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen is important for facilitating both education and allergen avoidance that are essential to long-term risk reduction. As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation and management of patients with idiopathic anaphylaxis. Within the last 10 years several apparently separate observations were recognized to be related, all of which resulted from the development of antibodies to a carbohydrate moiety on proteins. Interestingly, the exposure differed from airborne allergens but was nevertheless capable of producing anaphylactic and hypersensitivity reactions. Our recent work has identified these responses as being due to a novel IgE antibody directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose ("alpha-gal"). This review will present the historical summary of the identification of cetuximab hypersensitivity due to alpha-gal IgE and discuss the non-primate mammalian meat food allergy as well as current goals and directions of our research programs. SN - 1440-1592 UR - https://www.unboundmedicine.com/medline/citation/26666477/Delayed_anaphylaxis_to_alpha_gal_an_oligosaccharide_in_mammalian_meat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1323-8930(15)00197-5 DB - PRIME DP - Unbound Medicine ER -