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Transcranial direct current stimulation to enhance cognition in euthymic bipolar disorder.
Bipolar Disord. 2015 Dec; 17(8):849-58.BD

Abstract

OBJECTIVES

To investigate the use of transcranial direct current stimulation (tDCS) for enhancing working memory and sustained attention in euthymic patients with bipolar disorder.

METHODS

Fifteen patients with bipolar disorder received anodal left prefrontal tDCS with an extracephalic cathode (prefrontal condition), anodal left prefrontal and cathodal cerebellar tDCS (fronto-cerebellar condition), and sham tDCS given 'online' during performance on a working memory and sustained attention task in an intra-individual, cross-over, sham-controlled experimental design. Exploratory cluster analyses examined responders and non-responders for the different active tDCS conditions on both tasks.

RESULTS

For working memory, approximately one-third of patients in both active tDCS conditions showed performance improvement. For sustained attention, three of 15 patients showed performance improvement with prefrontal tDCS. Responders to active tDCS for working memory performed more poorly on the task during sham tDCS compared to non-responders.

CONCLUSIONS

A single session of active prefrontal or fronto-cerebellar tDCS failed to improve working memory or sustained attention performance in euthymic patients with bipolar disorder. Several important considerations are discussed in relation to future studies investigating tDCS for enhancing cognition in patients with bipolar disorder.

Authors+Show Affiliations

School of Psychiatry, Black Dog Institute, University of New South Wales, Sydney, Australia.Department of Psychiatry, Singapore General Hospital, Singapore.School of Psychiatry, Black Dog Institute, University of New South Wales, Sydney, Australia.School of Psychiatry, Black Dog Institute, University of New South Wales, Sydney, Australia.School of Psychiatry, Black Dog Institute, University of New South Wales, Sydney, Australia.School of Psychiatry, Black Dog Institute, University of New South Wales, Sydney, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26667520

Citation

Martin, Donel M., et al. "Transcranial Direct Current Stimulation to Enhance Cognition in Euthymic Bipolar Disorder." Bipolar Disorders, vol. 17, no. 8, 2015, pp. 849-58.
Martin DM, Chan HN, Alonzo A, et al. Transcranial direct current stimulation to enhance cognition in euthymic bipolar disorder. Bipolar Disord. 2015;17(8):849-58.
Martin, D. M., Chan, H. N., Alonzo, A., Green, M. J., Mitchell, P. B., & Loo, C. K. (2015). Transcranial direct current stimulation to enhance cognition in euthymic bipolar disorder. Bipolar Disorders, 17(8), 849-58. https://doi.org/10.1111/bdi.12350
Martin DM, et al. Transcranial Direct Current Stimulation to Enhance Cognition in Euthymic Bipolar Disorder. Bipolar Disord. 2015;17(8):849-58. PubMed PMID: 26667520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcranial direct current stimulation to enhance cognition in euthymic bipolar disorder. AU - Martin,Donel M, AU - Chan,Herng-Nieng, AU - Alonzo,Angelo, AU - Green,Melissa J, AU - Mitchell,Philip B, AU - Loo,Colleen K, Y1 - 2015/12/15/ PY - 2015/06/10/received PY - 2015/09/08/revised PY - 2015/10/12/accepted PY - 2015/12/16/entrez PY - 2015/12/17/pubmed PY - 2016/7/13/medline KW - bipolar disorder KW - sustained attention KW - transcranial direct current stimulation KW - working memory SP - 849 EP - 58 JF - Bipolar disorders JO - Bipolar Disord VL - 17 IS - 8 N2 - OBJECTIVES: To investigate the use of transcranial direct current stimulation (tDCS) for enhancing working memory and sustained attention in euthymic patients with bipolar disorder. METHODS: Fifteen patients with bipolar disorder received anodal left prefrontal tDCS with an extracephalic cathode (prefrontal condition), anodal left prefrontal and cathodal cerebellar tDCS (fronto-cerebellar condition), and sham tDCS given 'online' during performance on a working memory and sustained attention task in an intra-individual, cross-over, sham-controlled experimental design. Exploratory cluster analyses examined responders and non-responders for the different active tDCS conditions on both tasks. RESULTS: For working memory, approximately one-third of patients in both active tDCS conditions showed performance improvement. For sustained attention, three of 15 patients showed performance improvement with prefrontal tDCS. Responders to active tDCS for working memory performed more poorly on the task during sham tDCS compared to non-responders. CONCLUSIONS: A single session of active prefrontal or fronto-cerebellar tDCS failed to improve working memory or sustained attention performance in euthymic patients with bipolar disorder. Several important considerations are discussed in relation to future studies investigating tDCS for enhancing cognition in patients with bipolar disorder. SN - 1399-5618 UR - https://www.unboundmedicine.com/medline/citation/26667520/Transcranial_direct_current_stimulation_to_enhance_cognition_in_euthymic_bipolar_disorder_ L2 - https://doi.org/10.1111/bdi.12350 DB - PRIME DP - Unbound Medicine ER -