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Spectrofluorimetric determination of thioridazine and flupentixol in dosage forms; application to content uniformity test.
Luminescence. 2016 Aug; 31(5):1091-7.L

Abstract

A reliable, sensitive, cheap and non-extractive spectrofluorimetric method has been developed and validated for determination of thioridazine and flupentixol based on ternary complex formation with eosin and lead(II) in the presence of methylcellulose as surfactant at pH 3.2. Under the optimum conditions, the quantitative quenching effect of investigated drugs on the native fluorescence of eosin has been investigated. The quenching of the eosin fluorescence was measured at 517 nm after excitation at 462 nm. The different experimental parameters affecting the development and stability of the reaction products were carefully studied and optimized, and the results were satisfactory. The calibration plots were constructed over the range of 0.5-3.0 µg mL(-1) . The developed method was successfully applied for determination of investigated drugs in commercial tablets without interference from common excipients. It was further applied for content uniformity testing of flupentixol in its tablets. Statistical comparisons of the results with those of the reference methods revealed excellent agreement and indicated no significant difference in accuracy and precision. Copyright © 2015 John Wiley & Sons, Ltd.

Authors+Show Affiliations

Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26669624

Citation

Attia, Tamer Z., and Mahmoud A. Omar. "Spectrofluorimetric Determination of Thioridazine and Flupentixol in Dosage Forms; Application to Content Uniformity Test." Luminescence : the Journal of Biological and Chemical Luminescence, vol. 31, no. 5, 2016, pp. 1091-7.
Attia TZ, Omar MA. Spectrofluorimetric determination of thioridazine and flupentixol in dosage forms; application to content uniformity test. Luminescence. 2016;31(5):1091-7.
Attia, T. Z., & Omar, M. A. (2016). Spectrofluorimetric determination of thioridazine and flupentixol in dosage forms; application to content uniformity test. Luminescence : the Journal of Biological and Chemical Luminescence, 31(5), 1091-7. https://doi.org/10.1002/bio.3076
Attia TZ, Omar MA. Spectrofluorimetric Determination of Thioridazine and Flupentixol in Dosage Forms; Application to Content Uniformity Test. Luminescence. 2016;31(5):1091-7. PubMed PMID: 26669624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spectrofluorimetric determination of thioridazine and flupentixol in dosage forms; application to content uniformity test. AU - Attia,Tamer Z, AU - Omar,Mahmoud A, Y1 - 2015/12/16/ PY - 2015/08/07/received PY - 2015/11/11/revised PY - 2015/11/16/accepted PY - 2015/12/17/entrez PY - 2015/12/17/pubmed PY - 2017/3/9/medline KW - dosage forms KW - eosin KW - flupentixol KW - spectrofluorimetry KW - thioridazine SP - 1091 EP - 7 JF - Luminescence : the journal of biological and chemical luminescence JO - Luminescence VL - 31 IS - 5 N2 - A reliable, sensitive, cheap and non-extractive spectrofluorimetric method has been developed and validated for determination of thioridazine and flupentixol based on ternary complex formation with eosin and lead(II) in the presence of methylcellulose as surfactant at pH 3.2. Under the optimum conditions, the quantitative quenching effect of investigated drugs on the native fluorescence of eosin has been investigated. The quenching of the eosin fluorescence was measured at 517 nm after excitation at 462 nm. The different experimental parameters affecting the development and stability of the reaction products were carefully studied and optimized, and the results were satisfactory. The calibration plots were constructed over the range of 0.5-3.0 µg mL(-1) . The developed method was successfully applied for determination of investigated drugs in commercial tablets without interference from common excipients. It was further applied for content uniformity testing of flupentixol in its tablets. Statistical comparisons of the results with those of the reference methods revealed excellent agreement and indicated no significant difference in accuracy and precision. Copyright © 2015 John Wiley & Sons, Ltd. SN - 1522-7243 UR - https://www.unboundmedicine.com/medline/citation/26669624/Spectrofluorimetric_determination_of_thioridazine_and_flupentixol_in_dosage_forms L2 - https://doi.org/10.1002/bio.3076 DB - PRIME DP - Unbound Medicine ER -
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