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Differences in peripheral oxidative stress markers in Alzheimer's disease, vascular dementia and mixed dementia patients.
Geriatr Gerontol Int 2015; 15 Suppl 1:53-8GG

Abstract

AIMS

We determined whether the possible roles of oxidative stress differ in the pathophysiology and cognitive decline of Alzheimer's disease (AD), vascular dementia (VaD) and mixed Alzheimer's/vascular dementia (MD).

METHODS

We measured the levels of diacron reactive oxygen metabolite (dROM), reflecting the amount of organic hydroperoxides, and biological anti-oxidant potential (BAP), measuring the ferric reducing ability of blood plasma, in 72 patients with AD, 27 with VaD, 24 with MD and 53 non-demented outpatients (control group). In addition, endogenous plasma anti-oxidants, such as albumin, total bilirubin and uric acid, were compared among the groups. All participants with VaD and MD showed extensive white matter hyperintensity, in addition to multiple lacunes.

RESULTS

The dROM levels were significantly higher in the AD and MD groups than in the control group. The BAP levels were significantly lower in the MD group than in the control, AD and VaD groups. The AD group showed significantly lower levels of bilirubin and uric acid than the control group. The MD group showed a significantly lower level of albumin than the control and AD groups, and a significantly lower level of bilirubin than the control group. The Mini-Mental State examination scores correlated significantly with dROM levels and BAP/dROM ratios in the AD group.

CONCLUSIONS

An imbalance in pro-oxidant and anti-oxidant defenses is apparently involved in the pathophysiology of the AD and MD groups. The extent of oxidative stress damage might differ in subtypes of dementia by being greater in the MD group than in other types of dementia. Synergic effects of the degenerative element of AD and white matter lesions might be associated with oxidative stress damage in the MD group.

Authors+Show Affiliations

Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.Department of Geriatric Medicine, International University of Health and Welfare, Yaita, Japan.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26671158

Citation

Hatanaka, Hirokuni, et al. "Differences in Peripheral Oxidative Stress Markers in Alzheimer's Disease, Vascular Dementia and Mixed Dementia Patients." Geriatrics & Gerontology International, vol. 15 Suppl 1, 2015, pp. 53-8.
Hatanaka H, Hanyu H, Fukasawa R, et al. Differences in peripheral oxidative stress markers in Alzheimer's disease, vascular dementia and mixed dementia patients. Geriatr Gerontol Int. 2015;15 Suppl 1:53-8.
Hatanaka, H., Hanyu, H., Fukasawa, R., Hirao, K., Shimizu, S., Kanetaka, H., & Iwamoto, T. (2015). Differences in peripheral oxidative stress markers in Alzheimer's disease, vascular dementia and mixed dementia patients. Geriatrics & Gerontology International, 15 Suppl 1, pp. 53-8. doi:10.1111/ggi.12659.
Hatanaka H, et al. Differences in Peripheral Oxidative Stress Markers in Alzheimer's Disease, Vascular Dementia and Mixed Dementia Patients. Geriatr Gerontol Int. 2015;15 Suppl 1:53-8. PubMed PMID: 26671158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in peripheral oxidative stress markers in Alzheimer's disease, vascular dementia and mixed dementia patients. AU - Hatanaka,Hirokuni, AU - Hanyu,Haruo, AU - Fukasawa,Raita, AU - Hirao,Kentaro, AU - Shimizu,Soichiro, AU - Kanetaka,Hidekazu, AU - Iwamoto,Toshihiko, PY - 2015/09/17/accepted PY - 2015/12/17/entrez PY - 2015/12/17/pubmed PY - 2016/9/23/medline KW - Alzheimer's disease KW - anti-oxidants KW - mixed dementia KW - oxidative stress KW - vascular dementia SP - 53 EP - 8 JF - Geriatrics & gerontology international JO - Geriatr Gerontol Int VL - 15 Suppl 1 N2 - AIMS: We determined whether the possible roles of oxidative stress differ in the pathophysiology and cognitive decline of Alzheimer's disease (AD), vascular dementia (VaD) and mixed Alzheimer's/vascular dementia (MD). METHODS: We measured the levels of diacron reactive oxygen metabolite (dROM), reflecting the amount of organic hydroperoxides, and biological anti-oxidant potential (BAP), measuring the ferric reducing ability of blood plasma, in 72 patients with AD, 27 with VaD, 24 with MD and 53 non-demented outpatients (control group). In addition, endogenous plasma anti-oxidants, such as albumin, total bilirubin and uric acid, were compared among the groups. All participants with VaD and MD showed extensive white matter hyperintensity, in addition to multiple lacunes. RESULTS: The dROM levels were significantly higher in the AD and MD groups than in the control group. The BAP levels were significantly lower in the MD group than in the control, AD and VaD groups. The AD group showed significantly lower levels of bilirubin and uric acid than the control group. The MD group showed a significantly lower level of albumin than the control and AD groups, and a significantly lower level of bilirubin than the control group. The Mini-Mental State examination scores correlated significantly with dROM levels and BAP/dROM ratios in the AD group. CONCLUSIONS: An imbalance in pro-oxidant and anti-oxidant defenses is apparently involved in the pathophysiology of the AD and MD groups. The extent of oxidative stress damage might differ in subtypes of dementia by being greater in the MD group than in other types of dementia. Synergic effects of the degenerative element of AD and white matter lesions might be associated with oxidative stress damage in the MD group. SN - 1447-0594 UR - https://www.unboundmedicine.com/medline/citation/26671158/Differences_in_peripheral_oxidative_stress_markers_in_Alzheimer's_disease_vascular_dementia_and_mixed_dementia_patients_ L2 - https://doi.org/10.1111/ggi.12659 DB - PRIME DP - Unbound Medicine ER -