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[Lack of effectiveness of coenzyme Q10 (ubiquinone) in long-term treatment of dilated cardiomyopathy].
Z Kardiol 1989; 78(6):360-5ZK

Abstract

In a chronic, placebo-controlled, double-blind cross-over study a potential therapeutic effect of coenzyme Q10 (ubiquinone) was investigated in 25 patients suffering from dilative cardiomyopathy (NYHA functional class I, II, III). During a period of four months patients were treated with 3x 33.3 mg of coenzyme Q10 per day, given orally, 15 patients received verum during the first four months and placebo during the following four months (V/P). In the second group of patients (n = 10) the sequence of treatment was reversed (P/V). Therapeutic effect was assessed by means of echocardiogram, chest x-ray, radionuclide ventriculography combined with exercise test and impedance cardiography. Control values for left ventricular function parameters were similar in both groups (left ventricular ejection fraction: 39.5 +/- 11.5% (P/V), 37.6 +/- 17.0% (V/P); left ventricular enddiastolic diameter: 65 +/- 9 mm (P/V), 67 +/- 8 mm (V/P); Cl: 5.1 +/- 1.4 l/min (P/V), 5.1 +/- 1.1 l/min (V/P]. Chronic treatment by coenzyme Q10 did not exhibit any influence on hemodynamic parameters, on the electrocardiogram, on incidence of ventricular arrhythmias, or on exercise tolerance. It was not possible to demonstrate any therapeutic effect of coenzyme Q10 in patients with dilative cardiomyopathy.

Authors+Show Affiliations

Technische Universität München, I, Medizinische Klinik.

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

2667265

Citation

Permanetter, B, et al. "[Lack of Effectiveness of Coenzyme Q10 (ubiquinone) in Long-term Treatment of Dilated Cardiomyopathy]." Zeitschrift Fur Kardiologie, vol. 78, no. 6, 1989, pp. 360-5.
Permanetter B, Rössy W, Weingartner F, et al. [Lack of effectiveness of coenzyme Q10 (ubiquinone) in long-term treatment of dilated cardiomyopathy]. Z Kardiol. 1989;78(6):360-5.
Permanetter, B., Rössy, W., Weingartner, F., Bauer, R., Seidl, K. F., & Klein, G. (1989). [Lack of effectiveness of coenzyme Q10 (ubiquinone) in long-term treatment of dilated cardiomyopathy]. Zeitschrift Fur Kardiologie, 78(6), pp. 360-5.
Permanetter B, et al. [Lack of Effectiveness of Coenzyme Q10 (ubiquinone) in Long-term Treatment of Dilated Cardiomyopathy]. Z Kardiol. 1989;78(6):360-5. PubMed PMID: 2667265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Lack of effectiveness of coenzyme Q10 (ubiquinone) in long-term treatment of dilated cardiomyopathy]. AU - Permanetter,B, AU - Rössy,W, AU - Weingartner,F, AU - Bauer,R, AU - Seidl,K F, AU - Klein,G, PY - 1989/6/1/pubmed PY - 1989/6/1/medline PY - 1989/6/1/entrez SP - 360 EP - 5 JF - Zeitschrift fur Kardiologie JO - Z Kardiol VL - 78 IS - 6 N2 - In a chronic, placebo-controlled, double-blind cross-over study a potential therapeutic effect of coenzyme Q10 (ubiquinone) was investigated in 25 patients suffering from dilative cardiomyopathy (NYHA functional class I, II, III). During a period of four months patients were treated with 3x 33.3 mg of coenzyme Q10 per day, given orally, 15 patients received verum during the first four months and placebo during the following four months (V/P). In the second group of patients (n = 10) the sequence of treatment was reversed (P/V). Therapeutic effect was assessed by means of echocardiogram, chest x-ray, radionuclide ventriculography combined with exercise test and impedance cardiography. Control values for left ventricular function parameters were similar in both groups (left ventricular ejection fraction: 39.5 +/- 11.5% (P/V), 37.6 +/- 17.0% (V/P); left ventricular enddiastolic diameter: 65 +/- 9 mm (P/V), 67 +/- 8 mm (V/P); Cl: 5.1 +/- 1.4 l/min (P/V), 5.1 +/- 1.1 l/min (V/P]. Chronic treatment by coenzyme Q10 did not exhibit any influence on hemodynamic parameters, on the electrocardiogram, on incidence of ventricular arrhythmias, or on exercise tolerance. It was not possible to demonstrate any therapeutic effect of coenzyme Q10 in patients with dilative cardiomyopathy. SN - 0300-5860 UR - https://www.unboundmedicine.com/medline/citation/2667265/[Lack_of_effectiveness_of_coenzyme_Q10__ubiquinone__in_long_term_treatment_of_dilated_cardiomyopathy]_ L2 - http://www.diseaseinfosearch.org/result/2284 DB - PRIME DP - Unbound Medicine ER -