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The chronic effects of lignin-derived bisphenol and bisphenol A in Japanese medaka Oryzias latipes.
Aquat Toxicol. 2016 Jan; 170:199-207.AT

Abstract

One of the ultimate goals of green chemistry is to produce greener and more environmentally friendly chemicals to replace the existing toxic chemicals. In this study, Japanese medaka were exposed to 1.5mg/L of bisphenol A or lignin-derived bisphenol for 60 days, and the expressions of various biochemical markers, effects on reproduction, and histopathology were evaluated. The results showed that concentrations of liver vitellogenin of LD-BP exposed males were approximately 125% higher compared to the control males. Total number of eggs from the BPA and LD-BP exposed fish was approximately 47% (p<0.001) and 25% (p<0.05) less than the control fish, respectively. Total number of brood was lower from the BPA (46%, p<0.05) and LD-BP (17%, p<0.05) exposed fish than that of the control fish. Relative to the control fish, catalase and glutathione-S-transferase were significantly affected by the two chemicals in all tested tissues. BPA and LD-BP caused lipid peroxidation in all the tested tissues. Furthermore, acetylcholinesterase and α-glucosidase activity were significantly inhibited. Histopathological analysis showed that both the testis and ovary were mildly damaged by both chemicals. LD-BP affected medaka slightly more severe than BPA except on the reproduction, which was most likely due to different uptake, translocation, binding to targets and metabolism. Our results demonstrated that chronic exposure to both chemicals caused several adverse effects to medaka. Further research on the toxicity of LD-BP to other aquatic organisms is needed before substitution of traditional BPA with LD-BP can be recommended.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li D
Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, 110016, China.
Chen Q
Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023, China.
Cao J
State Key Laboratory of Ecological Animal Husbandry and Environmental Veterinary Medicine, Shanxi Agricultural University, 030801, China.
Chen H
Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, 110016, China.
Li L
Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, 110016, China.
Cedergreen N
Department of Plant and Environmental Science, Section of Environmental Chemistry and Physics, University of Copenhagen, 1871, Denmark.
Xie H
Department of Polymeric Materials and Engineering, College of Materials and Metallurgy Guizhou University, 550025, China.
Xie L
Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, 110016, China. Electronic address: xielt@iae.ac.cn.

MeSH

AcetylcholinesteraseAnimalsBenzhydryl CompoundsCatalaseEndocrine DisruptorsFemaleGillsGlutathione TransferaseGonadsJapanLiverMaleOryziasPhenolsReproductionSuperoxide DismutaseToxicity Tests, ChronicVitellogeninsWater Pollutants, Chemical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26674368

Citation

Li, Dan, et al. "The Chronic Effects of Lignin-derived Bisphenol and Bisphenol a in Japanese Medaka Oryzias Latipes." Aquatic Toxicology (Amsterdam, Netherlands), vol. 170, 2016, pp. 199-207.
Li D, Chen Q, Cao J, et al. The chronic effects of lignin-derived bisphenol and bisphenol A in Japanese medaka Oryzias latipes. Aquat Toxicol. 2016;170:199-207.
Li, D., Chen, Q., Cao, J., Chen, H., Li, L., Cedergreen, N., Xie, H., & Xie, L. (2016). The chronic effects of lignin-derived bisphenol and bisphenol A in Japanese medaka Oryzias latipes. Aquatic Toxicology (Amsterdam, Netherlands), 170, 199-207. https://doi.org/10.1016/j.aquatox.2015.11.024
Li D, et al. The Chronic Effects of Lignin-derived Bisphenol and Bisphenol a in Japanese Medaka Oryzias Latipes. Aquat Toxicol. 2016;170:199-207. PubMed PMID: 26674368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The chronic effects of lignin-derived bisphenol and bisphenol A in Japanese medaka Oryzias latipes. AU - Li,Dan, AU - Chen,Qin, AU - Cao,Jinling, AU - Chen,Hongxing, AU - Li,Lixia, AU - Cedergreen,Nina, AU - Xie,Haibo, AU - Xie,Lingtian, Y1 - 2015/11/26/ PY - 2015/09/17/received PY - 2015/11/22/revised PY - 2015/11/23/accepted PY - 2015/12/18/entrez PY - 2015/12/18/pubmed PY - 2016/8/6/medline KW - Bisphenol A KW - Histopathology KW - Japanese medaka KW - Lignin-derived bisphenol (LD-BP) KW - Reproduction KW - Vitellogenin SP - 199 EP - 207 JF - Aquatic toxicology (Amsterdam, Netherlands) JO - Aquat Toxicol VL - 170 N2 - One of the ultimate goals of green chemistry is to produce greener and more environmentally friendly chemicals to replace the existing toxic chemicals. In this study, Japanese medaka were exposed to 1.5mg/L of bisphenol A or lignin-derived bisphenol for 60 days, and the expressions of various biochemical markers, effects on reproduction, and histopathology were evaluated. The results showed that concentrations of liver vitellogenin of LD-BP exposed males were approximately 125% higher compared to the control males. Total number of eggs from the BPA and LD-BP exposed fish was approximately 47% (p<0.001) and 25% (p<0.05) less than the control fish, respectively. Total number of brood was lower from the BPA (46%, p<0.05) and LD-BP (17%, p<0.05) exposed fish than that of the control fish. Relative to the control fish, catalase and glutathione-S-transferase were significantly affected by the two chemicals in all tested tissues. BPA and LD-BP caused lipid peroxidation in all the tested tissues. Furthermore, acetylcholinesterase and α-glucosidase activity were significantly inhibited. Histopathological analysis showed that both the testis and ovary were mildly damaged by both chemicals. LD-BP affected medaka slightly more severe than BPA except on the reproduction, which was most likely due to different uptake, translocation, binding to targets and metabolism. Our results demonstrated that chronic exposure to both chemicals caused several adverse effects to medaka. Further research on the toxicity of LD-BP to other aquatic organisms is needed before substitution of traditional BPA with LD-BP can be recommended. SN - 1879-1514 UR - https://www.unboundmedicine.com/medline/citation/26674368/The_chronic_effects_of_lignin_derived_bisphenol_and_bisphenol_A_in_Japanese_medaka_Oryzias_latipes_ DB - PRIME DP - Unbound Medicine ER -