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Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women.
Am J Clin Nutr 2016; 103(1):100-6AJ

Abstract

BACKGROUND

Low selenium status in pregnancy has been associated with a number of adverse conditions. In nonpregnant populations, the selenium status or response to supplementation has been associated with polymorphisms in dimethylglycine dehydrogenase (DMGDH), selenoprotein P (SEPP1) and the glutathione peroxidases [cytosolic glutathione peroxidase (GPx1) and phospholipid glutathione peroxidase (GPx4)].

OBJECTIVE

We hypothesized that, in pregnant women, these candidate polymorphisms would be associated with selenium status in early pregnancy, its longitudinal change, and the interindividual response to selenium supplementation at 60 μg/d.

DESIGN

With the use of stored samples and data from the United Kingdom Selenium in Pregnancy Intervention (SPRINT) study in 227 pregnant women, we carried out genetic-association studies, testing for associations between selenium status, its longitudinal change, and response to supplementation and common genetic variation in DMGDH (rs921943), SEPP1 (rs3877899 and rs7579), GPx1 (rs1050450) and GPx4 (rs713041). Selenium status was represented by the concentration of whole-blood selenium at 12 and 35 wk of gestation, the concentration of toenail selenium at 16 wk of gestation, and plasma glutathione peroxidase (GPx3) activity at 12 and 35 wk of gestation.

RESULTS

Our results showed that DMGDH rs921943 was significantly associated with the whole-blood selenium concentration at 12 wk of gestation (P = 0.032), which explained ≤2.0% of the variance. This association was replicated with the use of toenail selenium (P = 0.043). In unsupplemented women, SEPP1 rs3877899 was significantly associated with the percentage change in whole-blood selenium from 12 to 35 wk of gestation (P = 0.005), which explained 8% of the variance. In supplemented women, SEPP1 rs3877899 was significantly associated with the percentage change in GPx3 activity from 12 to 35 wk of gestation (P = 0.01), which explained 5.3% of the variance. Selenium status was not associated with GPx1, GPx4, or SEPP1 rs7579.

CONCLUSIONS

In agreement with previous studies, we show that the genetic variant rs921943 in DMGDH is significantly associated with selenium status in United Kingdom pregnant women. Notably, our study shows that women who carry the SEPP1 rs3877899 A allele are better able to maintain selenium status during pregnancy, and their GPx3 activity increases more with supplementation, which suggests better protection from low selenium status. The SPRINT study was registered at www.isrctn.com as ISRCTN37927591.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, the First Hospital of China Medical University, Shenyang, China; Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom;School of Medical Science, Griffith Health Institute, Griffith University, Queensland, Australia; and.School of Medical Science, Griffith Health Institute, Griffith University, Queensland, Australia; and.Nuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, United Kingdom.Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom;Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom; m.rayman@surrey.ac.uk.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26675765

Citation

Mao, Jinyuan, et al. "Genetic Polymorphisms That Affect Selenium Status and Response to Selenium Supplementation in United Kingdom Pregnant Women." The American Journal of Clinical Nutrition, vol. 103, no. 1, 2016, pp. 100-6.
Mao J, Vanderlelie JJ, Perkins AV, et al. Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women. Am J Clin Nutr. 2016;103(1):100-6.
Mao, J., Vanderlelie, J. J., Perkins, A. V., Redman, C. W., Ahmadi, K. R., & Rayman, M. P. (2016). Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women. The American Journal of Clinical Nutrition, 103(1), pp. 100-6. doi:10.3945/ajcn.115.114231.
Mao J, et al. Genetic Polymorphisms That Affect Selenium Status and Response to Selenium Supplementation in United Kingdom Pregnant Women. Am J Clin Nutr. 2016;103(1):100-6. PubMed PMID: 26675765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women. AU - Mao,Jinyuan, AU - Vanderlelie,Jessica J, AU - Perkins,Anthony V, AU - Redman,Christopher W G, AU - Ahmadi,Kourosh R, AU - Rayman,Margaret P, Y1 - 2015/12/16/ PY - 2015/05/05/received PY - 2015/10/29/accepted PY - 2015/12/18/entrez PY - 2015/12/18/pubmed PY - 2016/5/3/medline KW - DMGDH KW - SEPP1 KW - polymorphisms KW - pregnancy KW - selenium status SP - 100 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 103 IS - 1 N2 - BACKGROUND: Low selenium status in pregnancy has been associated with a number of adverse conditions. In nonpregnant populations, the selenium status or response to supplementation has been associated with polymorphisms in dimethylglycine dehydrogenase (DMGDH), selenoprotein P (SEPP1) and the glutathione peroxidases [cytosolic glutathione peroxidase (GPx1) and phospholipid glutathione peroxidase (GPx4)]. OBJECTIVE: We hypothesized that, in pregnant women, these candidate polymorphisms would be associated with selenium status in early pregnancy, its longitudinal change, and the interindividual response to selenium supplementation at 60 μg/d. DESIGN: With the use of stored samples and data from the United Kingdom Selenium in Pregnancy Intervention (SPRINT) study in 227 pregnant women, we carried out genetic-association studies, testing for associations between selenium status, its longitudinal change, and response to supplementation and common genetic variation in DMGDH (rs921943), SEPP1 (rs3877899 and rs7579), GPx1 (rs1050450) and GPx4 (rs713041). Selenium status was represented by the concentration of whole-blood selenium at 12 and 35 wk of gestation, the concentration of toenail selenium at 16 wk of gestation, and plasma glutathione peroxidase (GPx3) activity at 12 and 35 wk of gestation. RESULTS: Our results showed that DMGDH rs921943 was significantly associated with the whole-blood selenium concentration at 12 wk of gestation (P = 0.032), which explained ≤2.0% of the variance. This association was replicated with the use of toenail selenium (P = 0.043). In unsupplemented women, SEPP1 rs3877899 was significantly associated with the percentage change in whole-blood selenium from 12 to 35 wk of gestation (P = 0.005), which explained 8% of the variance. In supplemented women, SEPP1 rs3877899 was significantly associated with the percentage change in GPx3 activity from 12 to 35 wk of gestation (P = 0.01), which explained 5.3% of the variance. Selenium status was not associated with GPx1, GPx4, or SEPP1 rs7579. CONCLUSIONS: In agreement with previous studies, we show that the genetic variant rs921943 in DMGDH is significantly associated with selenium status in United Kingdom pregnant women. Notably, our study shows that women who carry the SEPP1 rs3877899 A allele are better able to maintain selenium status during pregnancy, and their GPx3 activity increases more with supplementation, which suggests better protection from low selenium status. The SPRINT study was registered at www.isrctn.com as ISRCTN37927591. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26675765/Genetic_polymorphisms_that_affect_selenium_status_and_response_to_selenium_supplementation_in_United_Kingdom_pregnant_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.114231 DB - PRIME DP - Unbound Medicine ER -