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Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus on transient receptor potential Ion Channels.
Low Urin Tract Symptoms. 2010 Sep; 2(2):51-60.LU

Abstract

In the urine storage phase, mechanical stretch stimulates bladder afferents. These urinary bladder afferent sensory nerves consist of small diameter Aδ- and C-fibers running in the hypogastic and pelvic nerves. Neuroanatomical studies have revealed a complex neuronal network within the bladder wall. The exact mechanisms that underline mechano-sensory transduction in bladder afferent terminals remain ambiguous; however, a wide range of ion channels (e.g. TTX-resistant Na(+) channels, Kv channels and hyperpolarization-activated cyclic nucleotidegated cation channels, degenerin/epithelial Na+ channel), and receptors (e.g. TRPV1, TRPM8, TRPA1, P2X2/3, etc.) have been identified at bladder afferent terminals and have implicated in the generation and modulation of afferent signals, which are elcited by a wide range of bladder stimulations including physiological bladder filling, noxious distension, cold, chemical irritation and inflammation. The mammalian transient receptor potential (TRP) family consists of 28 channels that can be subdivided into six different classes: TRPV (Vanilloid), TRPC (Canonical), TRPM (Melastatin), TRPP (Polycystin), TRPML (Mucolipin), and TRPA (Ankyrin). TRP channels are activated by a diversity of physical (voltage, heat, cold, mechanical stress) or chemical (pH, osmolality) stimuli and by binding of specific ligands, enabling them to act as multifunctional sensors at the cellular level. TRPV1, TRPV2, TRPV4, TRPM8, and TRPA1 have been described in different parts of the urogenital tract. Although only TRPV1 among TRPs has been extensively studied so far, more evidence is slowly accumulating about the role of other TRP channels, ion channels, and receptors in the pathophysiology of the urogenital tract, and may provide a new strategy for the treatment of bladder dysfunction.

Authors+Show Affiliations

Department of Urology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan.Department of Urology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan.Department of Urology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan.Department of Urology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan.Department of Urology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan.Department of Urology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan.Department of Urology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan.Department of Urology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan.Department of Urology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Yamanashi, JapanDepartment of Urology, The First Affiliated Hospital, China Medical University, Shenyang, ChinaDepartment of Urology, Shiga University of Medical Science, Shiga, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26676284

Citation

Takeda, Masayuki, et al. "Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus On Transient Receptor Potential Ion Channels." Lower Urinary Tract Symptoms, vol. 2, no. 2, 2010, pp. 51-60.
Takeda M, Mochizuki T, Yoshiyama M, et al. Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus on transient receptor potential Ion Channels. Low Urin Tract Symptoms. 2010;2(2):51-60.
Takeda, M., Mochizuki, T., Yoshiyama, M., Nakagomi, H., Kobayashi, H., Sawada, N., Zakohji, H., DU, S., & Araki, I. (2010). Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus on transient receptor potential Ion Channels. Lower Urinary Tract Symptoms, 2(2), 51-60. https://doi.org/10.1111/j.1757-5672.2010.00074.x
Takeda M, et al. Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus On Transient Receptor Potential Ion Channels. Low Urin Tract Symptoms. 2010;2(2):51-60. PubMed PMID: 26676284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus on transient receptor potential Ion Channels. AU - Takeda,Masayuki, AU - Mochizuki,Tsutomu, AU - Yoshiyama,Mitsuharu, AU - Nakagomi,Hiroshi, AU - Kobayashi,Hideki, AU - Sawada,Norifumi, AU - Zakohji,Hidenori, AU - DU,Shuqi, AU - Araki,Isao, Y1 - 2010/08/13/ PY - 2015/12/18/entrez PY - 2010/9/1/pubmed PY - 2010/9/1/medline KW - epithelium KW - ion channel KW - sensory KW - transient receptor potential (TRP) KW - urinary bladder SP - 51 EP - 60 JF - Lower urinary tract symptoms JO - Low Urin Tract Symptoms VL - 2 IS - 2 N2 - In the urine storage phase, mechanical stretch stimulates bladder afferents. These urinary bladder afferent sensory nerves consist of small diameter Aδ- and C-fibers running in the hypogastic and pelvic nerves. Neuroanatomical studies have revealed a complex neuronal network within the bladder wall. The exact mechanisms that underline mechano-sensory transduction in bladder afferent terminals remain ambiguous; however, a wide range of ion channels (e.g. TTX-resistant Na(+) channels, Kv channels and hyperpolarization-activated cyclic nucleotidegated cation channels, degenerin/epithelial Na+ channel), and receptors (e.g. TRPV1, TRPM8, TRPA1, P2X2/3, etc.) have been identified at bladder afferent terminals and have implicated in the generation and modulation of afferent signals, which are elcited by a wide range of bladder stimulations including physiological bladder filling, noxious distension, cold, chemical irritation and inflammation. The mammalian transient receptor potential (TRP) family consists of 28 channels that can be subdivided into six different classes: TRPV (Vanilloid), TRPC (Canonical), TRPM (Melastatin), TRPP (Polycystin), TRPML (Mucolipin), and TRPA (Ankyrin). TRP channels are activated by a diversity of physical (voltage, heat, cold, mechanical stress) or chemical (pH, osmolality) stimuli and by binding of specific ligands, enabling them to act as multifunctional sensors at the cellular level. TRPV1, TRPV2, TRPV4, TRPM8, and TRPA1 have been described in different parts of the urogenital tract. Although only TRPV1 among TRPs has been extensively studied so far, more evidence is slowly accumulating about the role of other TRP channels, ion channels, and receptors in the pathophysiology of the urogenital tract, and may provide a new strategy for the treatment of bladder dysfunction. SN - 1757-5664 UR - https://www.unboundmedicine.com/medline/citation/26676284/Sensor_Mechanism_and_Afferent_Signal_Transduction_of_the_Urinary_Bladder:_Special_Focus_on_transient_receptor_potential_Ion_Channels_ L2 - https://doi.org/10.1111/j.1757-5672.2010.00074.x DB - PRIME DP - Unbound Medicine ER -
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