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Prognostic value of ABO blood group in patients with early stage cervical cancer treated with radical hysterectomy with pelvic node dissection.
Tumour Biol. 2016 Jun; 37(6):7421-30.TB

Abstract

This study aimed to evaluate the prognostic value of ABO blood groups in early-stage cervical cancer patients. The cohort included 413 patients diagnosed with stages IA2-IB1 cervical cancer who received a radical hysterectomy between 2002 and 2014. The 5-year recurrence-free survival (RFS) and overall survival (OS) were 93.13 and 96.81 % for blood group O, 87.68 and 88.22 % for blood group A, 81.66 and 89.40 % for blood group B, and 83.12 and 94.12 % for blood group AB groups, respectively. Patients were stratified for analysis as either blood group O or non-O. The 5-year RFS and OS were 93.13 and 96.81 % for blood group O and 83.66 and 89.76 % for blood group non-O, respectively. In multivariate analysis, age (P = 0.025), histology (P = 0.020), and deep stromal invasion (P = 0.006) were independent adverse prognostic factors for RFS, while the statistically significant independent prognostic factors for OS were age (P = 0.007) and parametrial involvement (P < 0.001). The Cox model did not show any significant effects of non-O blood group on survival outcome. However, a time-varying-effect Cox model revealed that the non-O blood group was associated with a worse RFS (hazard ratio (HR) 2.69, 95 % confidence interval (95%CI) 1.12-6.46, P = 0.017) and OS (HR 3.13, 95%CI 0.88-11.16, P = 0.053) during the first 5 years. These findings suggest that early-stage cervical cancer patients with a non-O blood group have poorer RFS than the O blood group, which is evidence during the first 5 years.

Authors+Show Affiliations

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand. hjitti@yahoo.com.Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand.Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26678885

Citation

Hanprasertpong, Jitti, et al. "Prognostic Value of ABO Blood Group in Patients With Early Stage Cervical Cancer Treated With Radical Hysterectomy With Pelvic Node Dissection." Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, vol. 37, no. 6, 2016, pp. 7421-30.
Hanprasertpong J, Jiamset I, Atjimakul T. Prognostic value of ABO blood group in patients with early stage cervical cancer treated with radical hysterectomy with pelvic node dissection. Tumour Biol. 2016;37(6):7421-30.
Hanprasertpong, J., Jiamset, I., & Atjimakul, T. (2016). Prognostic value of ABO blood group in patients with early stage cervical cancer treated with radical hysterectomy with pelvic node dissection. Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 37(6), 7421-30. https://doi.org/10.1007/s13277-015-4626-1
Hanprasertpong J, Jiamset I, Atjimakul T. Prognostic Value of ABO Blood Group in Patients With Early Stage Cervical Cancer Treated With Radical Hysterectomy With Pelvic Node Dissection. Tumour Biol. 2016;37(6):7421-30. PubMed PMID: 26678885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic value of ABO blood group in patients with early stage cervical cancer treated with radical hysterectomy with pelvic node dissection. AU - Hanprasertpong,Jitti, AU - Jiamset,Ingporn, AU - Atjimakul,Thiti, Y1 - 2015/12/17/ PY - 2015/11/03/received PY - 2015/12/10/accepted PY - 2015/12/19/entrez PY - 2015/12/19/pubmed PY - 2017/2/9/medline KW - ABO blood group KW - Cervical cancer KW - Prognosis KW - Radical hysterectomy KW - Survival SP - 7421 EP - 30 JF - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine JO - Tumour Biol. VL - 37 IS - 6 N2 - This study aimed to evaluate the prognostic value of ABO blood groups in early-stage cervical cancer patients. The cohort included 413 patients diagnosed with stages IA2-IB1 cervical cancer who received a radical hysterectomy between 2002 and 2014. The 5-year recurrence-free survival (RFS) and overall survival (OS) were 93.13 and 96.81 % for blood group O, 87.68 and 88.22 % for blood group A, 81.66 and 89.40 % for blood group B, and 83.12 and 94.12 % for blood group AB groups, respectively. Patients were stratified for analysis as either blood group O or non-O. The 5-year RFS and OS were 93.13 and 96.81 % for blood group O and 83.66 and 89.76 % for blood group non-O, respectively. In multivariate analysis, age (P = 0.025), histology (P = 0.020), and deep stromal invasion (P = 0.006) were independent adverse prognostic factors for RFS, while the statistically significant independent prognostic factors for OS were age (P = 0.007) and parametrial involvement (P < 0.001). The Cox model did not show any significant effects of non-O blood group on survival outcome. However, a time-varying-effect Cox model revealed that the non-O blood group was associated with a worse RFS (hazard ratio (HR) 2.69, 95 % confidence interval (95%CI) 1.12-6.46, P = 0.017) and OS (HR 3.13, 95%CI 0.88-11.16, P = 0.053) during the first 5 years. These findings suggest that early-stage cervical cancer patients with a non-O blood group have poorer RFS than the O blood group, which is evidence during the first 5 years. SN - 1423-0380 UR - https://www.unboundmedicine.com/medline/citation/26678885/Prognostic_value_of_ABO_blood_group_in_patients_with_early_stage_cervical_cancer_treated_with_radical_hysterectomy_with_pelvic_node_dissection_ L2 - https://link.springer.com/article/10.1007/s13277-015-4626-1 DB - PRIME DP - Unbound Medicine ER -