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HPV prevalence and type-distribution in cervical cancer and premalignant lesions of the cervix: A population-based study from Northern Ireland.
J Med Virol. 2016 Jul; 88(7):1262-70.JM

Abstract

Assessment of Human papillomavirus (HPV) prevalence and genotype distribution is important for monitoring the impact of prophylactic HPV vaccination. This study aimed to demonstrate the HPV genotypes predominating in pre-malignant and cervical cancers in Northern Ireland (NI) before the vaccination campaign has effect. Formalin fixed paraffin embedded tissue blocks from 2,303 women aged 16-93 years throughout NI were collated between April 2011 and February 2013. HPV DNA was amplified by PCR and HPV genotyping undertaken using the Roche(®) linear array detection kit. In total, 1,241 out of 1,830 eligible samples (68.0%) tested positive for HPV, with the majority of these [1,181/1,830 (64.5%)] having high-risk (HR) HPV infection; 37.4% were positive for HPV-16 (n = 684) and 5.1% for HPV-18 (n = 93). HPV type-specific prevalence was 48.1%, 65.9%, 81.3%, 92.2%, and 64.3% among cervical intraepithelial neoplasias (CIN) Grades I-III, squamous cell carcinomas (SCC) and adenocarcinoma (AC) cases, respectively. Most SCC cases (81.3%) had only one HPV genotype detected and almost a third (32.0%) of all cervical pathologies were HPV negative including 51.9% of CIN I (n = 283), 34.1% CIN II (n = 145), 18.7% of CIN III (n = 146), 7.8% of SCC (n = 5), and 35.7% of AC (n = 5) cases. This study provides important baseline data for monitoring the effect of HPV vaccination in NI and for comparison with other UK regions. The coverage of other HR-HPV genotypes apart from 16 and 18, including HPV-45, 31, 39, and 52, and the potential for cross protection, should be considered when considering future polyvalent vaccines.

Authors+Show Affiliations

Cancer Epidemiology and Health Services Research Group, Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland.Cancer Epidemiology and Health Services Research Group, Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland.Department of Cellular and Molecular Pathology, Antrim Area Hospital, Northern Health and Social Care Trust, Antrim, Northern Ireland.Department of Cellular and Molecular Pathology, Antrim Area Hospital, Northern Health and Social Care Trust, Antrim, Northern Ireland.Northern Ireland Cancer Registry, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26680281

Citation

Anderson, Lesley A., et al. "HPV Prevalence and Type-distribution in Cervical Cancer and Premalignant Lesions of the Cervix: a Population-based Study From Northern Ireland." Journal of Medical Virology, vol. 88, no. 7, 2016, pp. 1262-70.
Anderson LA, O'Rorke MA, Wilson R, et al. HPV prevalence and type-distribution in cervical cancer and premalignant lesions of the cervix: A population-based study from Northern Ireland. J Med Virol. 2016;88(7):1262-70.
Anderson, L. A., O'Rorke, M. A., Wilson, R., Jamison, J., & Gavin, A. T. (2016). HPV prevalence and type-distribution in cervical cancer and premalignant lesions of the cervix: A population-based study from Northern Ireland. Journal of Medical Virology, 88(7), 1262-70. https://doi.org/10.1002/jmv.24447
Anderson LA, et al. HPV Prevalence and Type-distribution in Cervical Cancer and Premalignant Lesions of the Cervix: a Population-based Study From Northern Ireland. J Med Virol. 2016;88(7):1262-70. PubMed PMID: 26680281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HPV prevalence and type-distribution in cervical cancer and premalignant lesions of the cervix: A population-based study from Northern Ireland. AU - Anderson,Lesley A, AU - O'Rorke,Michael A, AU - Wilson,Robbie, AU - Jamison,Jackie, AU - Gavin,Anna T, AU - ,, Y1 - 2016/01/05/ PY - 2015/12/14/accepted PY - 2015/12/19/entrez PY - 2015/12/19/pubmed PY - 2017/1/5/medline KW - cervical cancer KW - cervical intraepithelial neoplasia KW - frequency KW - human papillomavirus KW - population-based SP - 1262 EP - 70 JF - Journal of medical virology JO - J Med Virol VL - 88 IS - 7 N2 - Assessment of Human papillomavirus (HPV) prevalence and genotype distribution is important for monitoring the impact of prophylactic HPV vaccination. This study aimed to demonstrate the HPV genotypes predominating in pre-malignant and cervical cancers in Northern Ireland (NI) before the vaccination campaign has effect. Formalin fixed paraffin embedded tissue blocks from 2,303 women aged 16-93 years throughout NI were collated between April 2011 and February 2013. HPV DNA was amplified by PCR and HPV genotyping undertaken using the Roche(®) linear array detection kit. In total, 1,241 out of 1,830 eligible samples (68.0%) tested positive for HPV, with the majority of these [1,181/1,830 (64.5%)] having high-risk (HR) HPV infection; 37.4% were positive for HPV-16 (n = 684) and 5.1% for HPV-18 (n = 93). HPV type-specific prevalence was 48.1%, 65.9%, 81.3%, 92.2%, and 64.3% among cervical intraepithelial neoplasias (CIN) Grades I-III, squamous cell carcinomas (SCC) and adenocarcinoma (AC) cases, respectively. Most SCC cases (81.3%) had only one HPV genotype detected and almost a third (32.0%) of all cervical pathologies were HPV negative including 51.9% of CIN I (n = 283), 34.1% CIN II (n = 145), 18.7% of CIN III (n = 146), 7.8% of SCC (n = 5), and 35.7% of AC (n = 5) cases. This study provides important baseline data for monitoring the effect of HPV vaccination in NI and for comparison with other UK regions. The coverage of other HR-HPV genotypes apart from 16 and 18, including HPV-45, 31, 39, and 52, and the potential for cross protection, should be considered when considering future polyvalent vaccines. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/26680281/HPV_prevalence_and_type_distribution_in_cervical_cancer_and_premalignant_lesions_of_the_cervix:_A_population_based_study_from_Northern_Ireland_ L2 - https://doi.org/10.1002/jmv.24447 DB - PRIME DP - Unbound Medicine ER -