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[Improving venous tone and capillary sealing. Effect of a combination of Ruscus extract and hesperidine methyl chalcone in healthy probands in heat stress].
Fortschr Med. 1989 Jun 30; 107(19):52, 55-8.FM

Abstract

The drug combination of Ruscus-extract and hesperidine methyl chalcone (HMC) involves two basic mechanisms in the treatment of venous diseases: increase in venous tonicity and edema protection. This was shown in a double-blind study on 20 healthy volunteers by comparing the effectiveness of the individual substances, the combination and a placebo on the venous hemodynamics and the volume of the foot. Ruscus-extract augments the tonicity of the venous wall. This is expressed by a decrease in venous capacity (p less than 0.01), a reduction in the blood pool in the lower leg under orthostatic conditions, and a decrease in tissue volume of the foot and ankle (p less than 0.01). HMC lowers the capillary filtration rate (p less than 0.01) but augmented the blood pool. The increase in blood volume can be explained by dehydration of the tissue of the lower leg lowering the pressure of tissue on the venous system and increasing the blood pool in the limb. After administration of the combination, the blood volume was between the Ruscus and HMC volumes, while the effects on filtration rate, venous capacity and tissue volume corresponded to the changes seen after administration of HMC and Ruscus extract alone.

Authors

No affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article

Language

ger

PubMed ID

2668140

Citation

Rudofsky, G. "[Improving Venous Tone and Capillary Sealing. Effect of a Combination of Ruscus Extract and Hesperidine Methyl Chalcone in Healthy Probands in Heat Stress]." Fortschritte Der Medizin, vol. 107, no. 19, 1989, pp. 52, 55-8.
Rudofsky G. [Improving venous tone and capillary sealing. Effect of a combination of Ruscus extract and hesperidine methyl chalcone in healthy probands in heat stress]. Fortschr Med. 1989;107(19):52, 55-8.
Rudofsky, G. (1989). [Improving venous tone and capillary sealing. Effect of a combination of Ruscus extract and hesperidine methyl chalcone in healthy probands in heat stress]. Fortschritte Der Medizin, 107(19), 52, 55-8.
Rudofsky G. [Improving Venous Tone and Capillary Sealing. Effect of a Combination of Ruscus Extract and Hesperidine Methyl Chalcone in Healthy Probands in Heat Stress]. Fortschr Med. 1989 Jun 30;107(19):52, 55-8. PubMed PMID: 2668140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Improving venous tone and capillary sealing. Effect of a combination of Ruscus extract and hesperidine methyl chalcone in healthy probands in heat stress]. A1 - Rudofsky,G, PY - 1989/6/30/pubmed PY - 1989/6/30/medline PY - 1989/6/30/entrez SP - 52, 55-8 JF - Fortschritte der Medizin JO - Fortschr Med VL - 107 IS - 19 N2 - The drug combination of Ruscus-extract and hesperidine methyl chalcone (HMC) involves two basic mechanisms in the treatment of venous diseases: increase in venous tonicity and edema protection. This was shown in a double-blind study on 20 healthy volunteers by comparing the effectiveness of the individual substances, the combination and a placebo on the venous hemodynamics and the volume of the foot. Ruscus-extract augments the tonicity of the venous wall. This is expressed by a decrease in venous capacity (p less than 0.01), a reduction in the blood pool in the lower leg under orthostatic conditions, and a decrease in tissue volume of the foot and ankle (p less than 0.01). HMC lowers the capillary filtration rate (p less than 0.01) but augmented the blood pool. The increase in blood volume can be explained by dehydration of the tissue of the lower leg lowering the pressure of tissue on the venous system and increasing the blood pool in the limb. After administration of the combination, the blood volume was between the Ruscus and HMC volumes, while the effects on filtration rate, venous capacity and tissue volume corresponded to the changes seen after administration of HMC and Ruscus extract alone. SN - 0015-8178 UR - https://www.unboundmedicine.com/medline/citation/2668140/[Improving_venous_tone_and_capillary_sealing__Effect_of_a_combination_of_Ruscus_extract_and_hesperidine_methyl_chalcone_in_healthy_probands_in_heat_stress]_ L2 - https://medlineplus.gov/foothealth.html DB - PRIME DP - Unbound Medicine ER -