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A test of the additivity of acute toxicity of binary-metal mixtures of ni with Cd, Cu, and Zn to Daphnia magna, using the inflection point of the concentration-response curves.
Environ Toxicol Chem. 2016 07; 35(7):1843-51.ET

Abstract

Mixtures of metals are often present in surface waters, leading to toxicity that is difficult to predict. To provide data for development of multimetal toxicity models, Daphnia magna neonates were exposed to individual metals (Cd, Cu, Ni, Zn) and to binary combinations of those metals in standard 48-h lethality tests conducted in US Environmental Protection Agency moderately hard reconstituted water with 3 mg dissolved organic carbon (DOC)/L added as Suwannee River fulvic acid. Toxicity tests were performed with mixtures of Ni and 1) Cd, which is considerably more toxic than Ni; 2) Cu, which is less toxic than Cd but more toxic than Ni; and 3) Zn, which has a toxicity threshold similar to Ni. For each combination of metals in the binary mixtures, the concentration of 1 metal was held constant while the second metal was varied through a series that ranged from nonlethal to lethal concentrations; then the roles of the metals were reversed. Inflection points of the concentration-response curves were compared to test for additivity of toxicity. Sublethal concentrations of Ni caused less-than-additive toxicity with Cd, slightly less-than-additive toxicity with Zn, and greater-than-additive toxicity with Cu. One explanation of these results might be competition among the metals for binding to biological ligands and/or dissolved organic matter. Therefore, models might have to incorporate sometimes competing chemical interactions to accurately predict metal-mixture toxicity. Environ Toxicol Chem 2016;35:1843-1851. © 2015 SETAC.

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Authors+Show Affiliations

Traudt EM
Colorado School of Mines, Department of Chemistry and Geochemistry, Golden, Colorado, USA.
Ranville JF
Colorado School of Mines, Department of Chemistry and Geochemistry, Golden, Colorado, USA.
Smith SA
Colorado School of Mines, Department of Chemistry and Geochemistry, Golden, Colorado, USA.
Meyer JS
Colorado School of Mines, Department of Chemistry and Geochemistry, Golden, Colorado, USA. ARCADIS US, Lakewood, Colorado, USA.

MeSH

AnimalsCadmiumCopperDaphniaLigandsToxicity Tests, AcuteWater Pollutants, ChemicalZinc

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26681657

Citation

Traudt, Elizabeth M., et al. "A Test of the Additivity of Acute Toxicity of Binary-metal Mixtures of Ni With Cd, Cu, and Zn to Daphnia Magna, Using the Inflection Point of the Concentration-response Curves." Environmental Toxicology and Chemistry, vol. 35, no. 7, 2016, pp. 1843-51.
Traudt EM, Ranville JF, Smith SA, et al. A test of the additivity of acute toxicity of binary-metal mixtures of ni with Cd, Cu, and Zn to Daphnia magna, using the inflection point of the concentration-response curves. Environ Toxicol Chem. 2016;35(7):1843-51.
Traudt, E. M., Ranville, J. F., Smith, S. A., & Meyer, J. S. (2016). A test of the additivity of acute toxicity of binary-metal mixtures of ni with Cd, Cu, and Zn to Daphnia magna, using the inflection point of the concentration-response curves. Environmental Toxicology and Chemistry, 35(7), 1843-51. https://doi.org/10.1002/etc.3342
Traudt EM, et al. A Test of the Additivity of Acute Toxicity of Binary-metal Mixtures of Ni With Cd, Cu, and Zn to Daphnia Magna, Using the Inflection Point of the Concentration-response Curves. Environ Toxicol Chem. 2016;35(7):1843-51. PubMed PMID: 26681657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A test of the additivity of acute toxicity of binary-metal mixtures of ni with Cd, Cu, and Zn to Daphnia magna, using the inflection point of the concentration-response curves. AU - Traudt,Elizabeth M, AU - Ranville,James F, AU - Smith,Samantha A, AU - Meyer,Joseph S, Y1 - 2016/05/03/ PY - 2015/07/21/received PY - 2015/09/17/revised PY - 2015/12/12/accepted PY - 2015/12/19/entrez PY - 2015/12/19/pubmed PY - 2017/6/22/medline KW - Bioavailability KW - Independent action KW - Metal complexation KW - Metal-metal competition KW - Response addition SP - 1843 EP - 51 JF - Environmental toxicology and chemistry JO - Environ Toxicol Chem VL - 35 IS - 7 N2 - Mixtures of metals are often present in surface waters, leading to toxicity that is difficult to predict. To provide data for development of multimetal toxicity models, Daphnia magna neonates were exposed to individual metals (Cd, Cu, Ni, Zn) and to binary combinations of those metals in standard 48-h lethality tests conducted in US Environmental Protection Agency moderately hard reconstituted water with 3 mg dissolved organic carbon (DOC)/L added as Suwannee River fulvic acid. Toxicity tests were performed with mixtures of Ni and 1) Cd, which is considerably more toxic than Ni; 2) Cu, which is less toxic than Cd but more toxic than Ni; and 3) Zn, which has a toxicity threshold similar to Ni. For each combination of metals in the binary mixtures, the concentration of 1 metal was held constant while the second metal was varied through a series that ranged from nonlethal to lethal concentrations; then the roles of the metals were reversed. Inflection points of the concentration-response curves were compared to test for additivity of toxicity. Sublethal concentrations of Ni caused less-than-additive toxicity with Cd, slightly less-than-additive toxicity with Zn, and greater-than-additive toxicity with Cu. One explanation of these results might be competition among the metals for binding to biological ligands and/or dissolved organic matter. Therefore, models might have to incorporate sometimes competing chemical interactions to accurately predict metal-mixture toxicity. Environ Toxicol Chem 2016;35:1843-1851. © 2015 SETAC. SN - 1552-8618 UR - https://www.unboundmedicine.com/medline/citation/26681657/A_test_of_the_additivity_of_acute_toxicity_of_binary_metal_mixtures_of_ni_with_Cd_Cu_and_Zn_to_Daphnia_magna_using_the_inflection_point_of_the_concentration_response_curves_ DB - PRIME DP - Unbound Medicine ER -