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Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study.
Clin Nutr 2017; 36(1):267-274CN

Abstract

BACKGROUND & AIM

Sarcopenia, the age-related decrease in muscle mass, strength, and function, is a main cause of reduced mobility, increased falls, fractures and nursing home admissions. Cross-sectional and prospective studies indicate that sarcopenia may be influenced in part by reversible factors like nutritional intake. The aim of this study was to compare functional and nutritional status, body composition, and quality of life of older adults between age and sex-matched older adults with and without sarcopenia.

METHODS

In a multi-centre setting, non-sarcopenic older adults (n = 66, mean ± SD: 71 ± 4 y), i.e. Short Physical Performance Battery (SPPB): 11-12 and normal skeletal muscle mass index, were recruited to match 1:1 by age and sex to previously recruited adults with sarcopenia: SPPB 4-9 and low skeletal muscle mass index. Health-related quality of life, self-reported physical activity levels and dietary intakes were measured using the EQ-5D scale and index, Physical Activity Scale for the Elderly (PASE), and 3-day prospective diet records, respectively. Concentrations of 25-OH-vitamin D, α-tocopherol (adjusted for cholesterol), folate, and vitamin B-12 were assessed in serum samples.

RESULTS

In addition to the defined components of sarcopenia, i.e. muscle mass, strength and function, reported physical activity levels and health-related quality of life were lower in the sarcopenic adults (p < 0.001). For similar energy intakes (mean ± SD: sarcopenic, 1710 ± 418; non-sarcopenic, 1745 ± 513, p = 0.50), the sarcopenic group consumed less protein/kg (-6%), vitamin D (-38%), vitamin B-12 (-22%), magnesium (-6%), phosphorus (-5%), and selenium (-2%) (all p < 0.05) compared to the non-sarcopenic controls. The serum concentration of vitamin B-12 was 15% lower in the sarcopenic group (p = 0.015), and all other nutrient concentrations were similar between groups.

CONCLUSIONS

In non-malnourished older adults with and without sarcopenia, we observed that sarcopenia substantially impacted self-reported quality of life and physical activity levels. Differences in nutrient concentrations and dietary intakes were identified, which might be related to the differences in muscle mass, strength and function between the two groups. This study provides information to help strengthen the characterization of this geriatric syndrome sarcopenia and indicates potential target areas for nutritional interventions.

Authors+Show Affiliations

Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands; Department of Internal Medicine, Section of Gerontology and Geriatrics, VU University Medical Center, Amsterdam, The Netherlands.The Bone Clinic, Newcastle upon Tyne Hospitals Trust, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.Department of Geriatric Medicine, Carl von Ossietzky University, Oldenburg, Germany.Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Department of Geriatric Medicine, Uppsala University Hospital, Sweden.Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands.Human Nutrition Research Centre, School of Agriculture, Food and Rural Development, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom.School of Healthcare Science, Manchester Metropolitan University, United Kingdom.School of Healthcare Science, Manchester Metropolitan University, United Kingdom.Human Nutrition Research Centre, School of Agriculture, Food and Rural Development, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom.Friedrich-Alexander-University Erlangen-Nürnberg, Nürnberg, Germany.Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands.Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands.Human Nutrition Research Centre, School of Agriculture, Food and Rural Development, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom.

Pub Type(s)

Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26689868

Citation

Verlaan, Sjors, et al. "Nutritional Status, Body Composition, and Quality of Life in Community-dwelling Sarcopenic and Non-sarcopenic Older Adults: a Case-control Study." Clinical Nutrition (Edinburgh, Scotland), vol. 36, no. 1, 2017, pp. 267-274.
Verlaan S, Aspray TJ, Bauer JM, et al. Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study. Clin Nutr. 2017;36(1):267-274.
Verlaan, S., Aspray, T. J., Bauer, J. M., Cederholm, T., Hemsworth, J., Hill, T. R., ... Brandt, K. (2017). Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study. Clinical Nutrition (Edinburgh, Scotland), 36(1), pp. 267-274. doi:10.1016/j.clnu.2015.11.013.
Verlaan S, et al. Nutritional Status, Body Composition, and Quality of Life in Community-dwelling Sarcopenic and Non-sarcopenic Older Adults: a Case-control Study. Clin Nutr. 2017;36(1):267-274. PubMed PMID: 26689868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study. AU - Verlaan,Sjors, AU - Aspray,Terry J, AU - Bauer,Juergen M, AU - Cederholm,Tommy, AU - Hemsworth,Jaimie, AU - Hill,Tom R, AU - McPhee,Jamie S, AU - Piasecki,Mathew, AU - Seal,Chris, AU - Sieber,Cornel C, AU - Ter Borg,Sovianne, AU - Wijers,Sander L, AU - Brandt,Kirsten, Y1 - 2015/11/27/ PY - 2015/09/22/received PY - 2015/11/02/revised PY - 2015/11/22/accepted PY - 2015/12/23/pubmed PY - 2018/3/1/medline PY - 2015/12/23/entrez KW - Frailty KW - Micronutrient KW - Observational KW - Protein KW - Sarcopenia SP - 267 EP - 274 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 36 IS - 1 N2 - BACKGROUND & AIM: Sarcopenia, the age-related decrease in muscle mass, strength, and function, is a main cause of reduced mobility, increased falls, fractures and nursing home admissions. Cross-sectional and prospective studies indicate that sarcopenia may be influenced in part by reversible factors like nutritional intake. The aim of this study was to compare functional and nutritional status, body composition, and quality of life of older adults between age and sex-matched older adults with and without sarcopenia. METHODS: In a multi-centre setting, non-sarcopenic older adults (n = 66, mean ± SD: 71 ± 4 y), i.e. Short Physical Performance Battery (SPPB): 11-12 and normal skeletal muscle mass index, were recruited to match 1:1 by age and sex to previously recruited adults with sarcopenia: SPPB 4-9 and low skeletal muscle mass index. Health-related quality of life, self-reported physical activity levels and dietary intakes were measured using the EQ-5D scale and index, Physical Activity Scale for the Elderly (PASE), and 3-day prospective diet records, respectively. Concentrations of 25-OH-vitamin D, α-tocopherol (adjusted for cholesterol), folate, and vitamin B-12 were assessed in serum samples. RESULTS: In addition to the defined components of sarcopenia, i.e. muscle mass, strength and function, reported physical activity levels and health-related quality of life were lower in the sarcopenic adults (p < 0.001). For similar energy intakes (mean ± SD: sarcopenic, 1710 ± 418; non-sarcopenic, 1745 ± 513, p = 0.50), the sarcopenic group consumed less protein/kg (-6%), vitamin D (-38%), vitamin B-12 (-22%), magnesium (-6%), phosphorus (-5%), and selenium (-2%) (all p < 0.05) compared to the non-sarcopenic controls. The serum concentration of vitamin B-12 was 15% lower in the sarcopenic group (p = 0.015), and all other nutrient concentrations were similar between groups. CONCLUSIONS: In non-malnourished older adults with and without sarcopenia, we observed that sarcopenia substantially impacted self-reported quality of life and physical activity levels. Differences in nutrient concentrations and dietary intakes were identified, which might be related to the differences in muscle mass, strength and function between the two groups. This study provides information to help strengthen the characterization of this geriatric syndrome sarcopenia and indicates potential target areas for nutritional interventions. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/26689868/Nutritional_status_body_composition_and_quality_of_life_in_community_dwelling_sarcopenic_and_non_sarcopenic_older_adults:_A_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(15)00333-7 DB - PRIME DP - Unbound Medicine ER -