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Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines--Flos Lonicerae Japonicae--Fructus Forsythiae Herb Couples as an Example.
Int J Mol Sci. 2015 Dec 04; 16(12):28812-40.IJ

Abstract

Traditional Chinese medicines (TCMs) have attracted extensive interest throughout the world due to their long history of health protection and disease control, and the internalization of TCM preparations or patented drugs has been considered a wind vane in the process of TCM modernization. However, multi-target effects, caused by multiple components in TCMs, hinder not only the construction of the quality evaluation system (bioavailability), but also the application of pharmaceutical technologies, which results in the poor efficacy in clinical practice. This review describes the methods in the literature as well as in our thoughts about how to identify the marker components, establish the evaluation system of bioavailability, and improve the bioavailability in TCM preparations. We expect that the current study will be positive and informative.

Authors+Show Affiliations

College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. zhouwei19860506@163.com. Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 210023, China. zhouwei19860506@163.com. Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, Nanjing 210023, China. zhouwei19860506@163.com. Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. zhouwei19860506@163.com.College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. bccai@126.com. Nanjing Haichang Chinese Medicine Group Co., Ltd., Nanjing 210023, China. bccai@126.com.Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. dfsjj@163.com.Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. wscnj@126.com.College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. diliuqing@hotmail.com. Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 210023, China. diliuqing@hotmail.com. Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, Nanjing 210023, China. diliuqing@hotmail.com. Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. diliuqing@hotmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26690115

Citation

Zhou, Wei, et al. "Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines--Flos Lonicerae Japonicae--Fructus Forsythiae Herb Couples as an Example." International Journal of Molecular Sciences, vol. 16, no. 12, 2015, pp. 28812-40.
Zhou W, Cai B, Shan J, et al. Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines--Flos Lonicerae Japonicae--Fructus Forsythiae Herb Couples as an Example. Int J Mol Sci. 2015;16(12):28812-40.
Zhou, W., Cai, B., Shan, J., Wang, S., & Di, L. (2015). Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines--Flos Lonicerae Japonicae--Fructus Forsythiae Herb Couples as an Example. International Journal of Molecular Sciences, 16(12), 28812-40. https://doi.org/10.3390/ijms161226132
Zhou W, et al. Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines--Flos Lonicerae Japonicae--Fructus Forsythiae Herb Couples as an Example. Int J Mol Sci. 2015 Dec 4;16(12):28812-40. PubMed PMID: 26690115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines--Flos Lonicerae Japonicae--Fructus Forsythiae Herb Couples as an Example. AU - Zhou,Wei, AU - Cai,Baochang, AU - Shan,Jinjun, AU - Wang,Shouchuan, AU - Di,Liuqing, Y1 - 2015/12/04/ PY - 2015/10/21/received PY - 2015/11/21/revised PY - 2015/11/24/accepted PY - 2015/12/23/entrez PY - 2015/12/23/pubmed PY - 2016/10/8/medline KW - absorption enhancer KW - active constitutes identification KW - bio-pharmaceutics of TCMs preparations KW - evaluation system of bioavailability KW - pharmaceutical technologies SP - 28812 EP - 40 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 16 IS - 12 N2 - Traditional Chinese medicines (TCMs) have attracted extensive interest throughout the world due to their long history of health protection and disease control, and the internalization of TCM preparations or patented drugs has been considered a wind vane in the process of TCM modernization. However, multi-target effects, caused by multiple components in TCMs, hinder not only the construction of the quality evaluation system (bioavailability), but also the application of pharmaceutical technologies, which results in the poor efficacy in clinical practice. This review describes the methods in the literature as well as in our thoughts about how to identify the marker components, establish the evaluation system of bioavailability, and improve the bioavailability in TCM preparations. We expect that the current study will be positive and informative. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/26690115/Discovery_and_Current_Status_of_Evaluation_System_of_Bioavailability_and_Related_Pharmaceutical_Technologies_for_Traditional_Chinese_Medicines__Flos_Lonicerae_Japonicae__Fructus_Forsythiae_Herb_Couples_as_an_Example_ L2 - http://www.mdpi.com/resolver?pii=ijms161226132 DB - PRIME DP - Unbound Medicine ER -