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Effect of influenza vaccination on the prognosis of hospitalized influenza patients.

Abstract

OBJECTIVES

This study aimed to assess whether influenza vaccination reduces the risk of severe and fatal outcomes in influenza inpatients aged ≥65 years.

METHODS

During the 2013-2014 influenza season persons aged ≥65 years hospitalized with laboratory-confirmed influenza were selected in 19 Spanish hospitals. A severe influenza case was defined as admission to the intensive care unit, death in hospital or within 30 days after admission. Logistic regression was used to compare the influenza vaccination status between severe and non-severe influenza inpatients.

RESULTS

Of 433 influenza confirmed patients, 81 (19%) were severe cases. Vaccination reduced the risk of severe illness (odds ratio: 0.57; 95%CI: 0.33-0.98). The cumulative number of influenza vaccine doses received since the 2010-2011 season was associated with a lower risk of severe influenza (odds ratio: 0.78; 95% CI 0.66-0.91).

CONCLUSION

Adherence to seasonal influenza vaccination in the elderly may reduce the risk of severe influenza outcomes.

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  • Publisher Full Text
  • Authors+Show Affiliations

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    a Instituto de Salud Pública de Navarra , IdiSNA - Navarra Institute for Health Research , Pamplona , Spain.

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    b CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid , Spain. c Departament de Salut Pública , Universitat de Barcelona , Barcelona , Spain.

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    c Departament de Salut Pública , Universitat de Barcelona , Barcelona , Spain.

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    d Servicio de Medicina Preventiva, Complejo Hospitalario de Navarra , Pamplona , Spain.

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    e Unidad de Enfermedades Infecciosas, Hospital de Mataró , Mataró , Spain.

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    b CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid , Spain. c Departament de Salut Pública , Universitat de Barcelona , Barcelona , Spain.

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    f Dirección de Salud Pública, Consejería de Sanidad , Madrid , Spain.

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    g Servicio de Neumología, Hospital de Galdakao , Usansolo , Spain.

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    b CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid , Spain. h Agència de Salut Pública de Catalunya , Barcelona , Spain. i Institut de Recerca Biomèdica de Lleida , Universitat de Lleida , Lleida , Spain.

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    j Servicio de Vigilancia, Junta de Andalucía , Sevilla , Spain.

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    k Dirección General de Salud Pública, Investigación, Desarrollo e Innovación , Valladolid , Spain.

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    l Servicio de Neumología, Consorci Hospital General Universitari de Valencia , Valencia , Spain.

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    a Instituto de Salud Pública de Navarra , IdiSNA - Navarra Institute for Health Research , Pamplona , Spain. b CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid , Spain.

    Source

    Expert review of vaccines 15:3 2016 pg 425-32

    MeSH

    Aged
    Aged, 80 and over
    Case-Control Studies
    Critical Care
    Female
    Hospitalization
    Humans
    Influenza Vaccines
    Influenza, Human
    Male
    Prognosis
    Spain
    Survival Analysis
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26690376

    Citation

    Casado, Itziar, et al. "Effect of Influenza Vaccination On the Prognosis of Hospitalized Influenza Patients." Expert Review of Vaccines, vol. 15, no. 3, 2016, pp. 425-32.
    Casado I, Domínguez A, Toledo D, et al. Effect of influenza vaccination on the prognosis of hospitalized influenza patients. Expert Rev Vaccines. 2016;15(3):425-32.
    Casado, I., Domínguez, A., Toledo, D., Chamorro, J., Force, L., Soldevila, N., ... Castilla, J. (2016). Effect of influenza vaccination on the prognosis of hospitalized influenza patients. Expert Review of Vaccines, 15(3), pp. 425-32. doi:10.1586/14760584.2016.1134328.
    Casado I, et al. Effect of Influenza Vaccination On the Prognosis of Hospitalized Influenza Patients. Expert Rev Vaccines. 2016;15(3):425-32. PubMed PMID: 26690376.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of influenza vaccination on the prognosis of hospitalized influenza patients. AU - Casado,Itziar, AU - Domínguez,Angela, AU - Toledo,Diana, AU - Chamorro,Judith, AU - Force,Lluis, AU - Soldevila,Núria, AU - Astray,Jenaro, AU - Egurrola,Mikel, AU - Godoy,Pere, AU - Mayoral,José M, AU - Tamames,Sonia, AU - Sanz,Francisco, AU - Castilla,Jesús, AU - ,, Y1 - 2016/01/20/ PY - 2015/12/23/entrez PY - 2015/12/23/pubmed PY - 2016/11/9/medline KW - Influenza virus KW - mortality KW - seasonal influenza vaccine KW - severe influenza KW - vaccine effectiveness SP - 425 EP - 32 JF - Expert review of vaccines JO - Expert Rev Vaccines VL - 15 IS - 3 N2 - OBJECTIVES: This study aimed to assess whether influenza vaccination reduces the risk of severe and fatal outcomes in influenza inpatients aged ≥65 years. METHODS: During the 2013-2014 influenza season persons aged ≥65 years hospitalized with laboratory-confirmed influenza were selected in 19 Spanish hospitals. A severe influenza case was defined as admission to the intensive care unit, death in hospital or within 30 days after admission. Logistic regression was used to compare the influenza vaccination status between severe and non-severe influenza inpatients. RESULTS: Of 433 influenza confirmed patients, 81 (19%) were severe cases. Vaccination reduced the risk of severe illness (odds ratio: 0.57; 95%CI: 0.33-0.98). The cumulative number of influenza vaccine doses received since the 2010-2011 season was associated with a lower risk of severe influenza (odds ratio: 0.78; 95% CI 0.66-0.91). CONCLUSION: Adherence to seasonal influenza vaccination in the elderly may reduce the risk of severe influenza outcomes. SN - 1744-8395 UR - https://www.unboundmedicine.com/medline/citation/26690376/Effect_of_influenza_vaccination_on_the_prognosis_of_hospitalized_influenza_patients_ L2 - http://www.tandfonline.com/doi/full/10.1586/14760584.2016.1134328 DB - PRIME DP - Unbound Medicine ER -