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Dietary pattern and antioxidants in plasma and erythrocyte in patients with mild cognitive impairment from China.
Nutrition. 2016 Feb; 32(2):193-8.N

Abstract

OBJECTIVES

Oxidative stress and unhealthy dietary patterns are might correlate with the risk of mild cognitive impairment (MCI) patients to develop Alzheimer's disease. We explored the association between dietary pattern, plasma and erythrocyte antioxidants levels, and cognitive function in the older Chinese adults.

METHODS

The present study is a case-control study. A total of 138 MCI patients and 138 age- and sex-matched healthy subjects (aged from 55 to 75) were recruited. A food frequency questionnaire method was used for the dietary survey. Peripheral blood and morning spot urine were sampled for parameters detection. Cognitive function of the old subjects was measured by using the Montreal Cognitive Assessment test. Antioxidant parameters in plasma, erythrocyte, and urine samples were measured by using the assay kits. Plasma retinol, α-tocopherol, and flavonoids contents were detected by using high performance liquid chromatography and liquid chromatography mass spectrometer methods respectively.

RESULTS

The MCI patients had lower plasma total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol than control subjects (P < 0.01). MCI patients consumed less fish and more red meat daily than the controls (P < 0.05). Comparing with controls, lower plasma total antioxidant capacity, α-tocopherol, and higher level of malondialdehyde were detected in the MCI patients (P < 0.05). No significant difference of plasma flavonoids concentration, erythrocyte antioxidant enzyme activities, and urinary 8-hydroxy-2'-deoxyguanosine content was detected among the MCI and control subjects (P > 0.05).

CONCLUSIONS

Lower plasma concentration of high-density lipoprotein cholesterol, total antioxidant capacity, and α-tocopherol levels, and a dietary pattern that is low in fish and high in red meat might contribute to the cognition impairment in older Chinese adults.

Authors+Show Affiliations

School of Public Health, Capital Medical University, Beijing, China.School of Public Health, Capital Medical University, Beijing, China.School of Public Health, Capital Medical University, Beijing, China.School of Public Health, Capital Medical University, Beijing, China.School of Public Health, Capital Medical University, Beijing, China.School of Public Health, Capital Medical University, Beijing, China.School of Public Health, Capital Medical University, Beijing, China. Electronic address: xiaor22@ccmu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26690564

Citation

Yuan, Linhong, et al. "Dietary Pattern and Antioxidants in Plasma and Erythrocyte in Patients With Mild Cognitive Impairment From China." Nutrition (Burbank, Los Angeles County, Calif.), vol. 32, no. 2, 2016, pp. 193-8.
Yuan L, Liu J, Ma W, et al. Dietary pattern and antioxidants in plasma and erythrocyte in patients with mild cognitive impairment from China. Nutrition. 2016;32(2):193-8.
Yuan, L., Liu, J., Ma, W., Dong, L., Wang, W., Che, R., & Xiao, R. (2016). Dietary pattern and antioxidants in plasma and erythrocyte in patients with mild cognitive impairment from China. Nutrition (Burbank, Los Angeles County, Calif.), 32(2), 193-8. https://doi.org/10.1016/j.nut.2015.08.004
Yuan L, et al. Dietary Pattern and Antioxidants in Plasma and Erythrocyte in Patients With Mild Cognitive Impairment From China. Nutrition. 2016;32(2):193-8. PubMed PMID: 26690564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary pattern and antioxidants in plasma and erythrocyte in patients with mild cognitive impairment from China. AU - Yuan,Linhong, AU - Liu,Jinmeng, AU - Ma,Weiwei, AU - Dong,Li, AU - Wang,Wenjuan, AU - Che,Ruiwen, AU - Xiao,Rong, Y1 - 2015/09/01/ PY - 2015/03/19/received PY - 2015/08/03/revised PY - 2015/08/06/accepted PY - 2015/12/23/entrez PY - 2015/12/23/pubmed PY - 2016/12/16/medline KW - Antioxidant KW - Cognitive function KW - Diet pattern KW - Elderly KW - Mild cognitive impairment SP - 193 EP - 8 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 32 IS - 2 N2 - OBJECTIVES: Oxidative stress and unhealthy dietary patterns are might correlate with the risk of mild cognitive impairment (MCI) patients to develop Alzheimer's disease. We explored the association between dietary pattern, plasma and erythrocyte antioxidants levels, and cognitive function in the older Chinese adults. METHODS: The present study is a case-control study. A total of 138 MCI patients and 138 age- and sex-matched healthy subjects (aged from 55 to 75) were recruited. A food frequency questionnaire method was used for the dietary survey. Peripheral blood and morning spot urine were sampled for parameters detection. Cognitive function of the old subjects was measured by using the Montreal Cognitive Assessment test. Antioxidant parameters in plasma, erythrocyte, and urine samples were measured by using the assay kits. Plasma retinol, α-tocopherol, and flavonoids contents were detected by using high performance liquid chromatography and liquid chromatography mass spectrometer methods respectively. RESULTS: The MCI patients had lower plasma total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol than control subjects (P < 0.01). MCI patients consumed less fish and more red meat daily than the controls (P < 0.05). Comparing with controls, lower plasma total antioxidant capacity, α-tocopherol, and higher level of malondialdehyde were detected in the MCI patients (P < 0.05). No significant difference of plasma flavonoids concentration, erythrocyte antioxidant enzyme activities, and urinary 8-hydroxy-2'-deoxyguanosine content was detected among the MCI and control subjects (P > 0.05). CONCLUSIONS: Lower plasma concentration of high-density lipoprotein cholesterol, total antioxidant capacity, and α-tocopherol levels, and a dietary pattern that is low in fish and high in red meat might contribute to the cognition impairment in older Chinese adults. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/26690564/Dietary_pattern_and_antioxidants_in_plasma_and_erythrocyte_in_patients_with_mild_cognitive_impairment_from_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(15)00339-1 DB - PRIME DP - Unbound Medicine ER -