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Seroprevalence of Human T-Cell Lymphotropic Virus-1/2 in Blood Donors in Northern Pakistan: Implications for Blood Donor Screening.
J Coll Physicians Surg Pak. 2015 Dec; 25(12):874-7.JC

Abstract

OBJECTIVE

To determine the seroprevalence of Human T-cell Lymphotropic Virus-1/2 (HTLV-1/2) in blood donors in Northern Pakistan.

STUDY DESIGN

Descriptive study.

PLACE AND DURATION OF STUDY

Armed Forces Institute of Transfusion, Rawalpindi, from July to August 2013.

METHODOLOGY

A total of 2100 blood donors were screened for anti-HTLV-1/2 antibodies during the study period, in a pool of six, on a highly sensitive, Chemiluminiscent Microparticle Immunoassay (CMIA) based system. The screening test-reactive donors were recalled, counseled and interviewed, and a fresh sample was obtained for confirmatory testing. Confirmation was performed using additional immunoassays including Line Immunoassay (LIA); with additional testing for HTLV-1 pvDNAPCR. Frequency and percentages were determined.

RESULTS

Four donors (0.19%) were repeatedly screening test-reactive and were subsequently confirmed to be HTLV-1 infected by line immunoassay and HTLV-1 pvDNAPCR. All four donors were male with mean age of 27 ± 6.27 years. Two (50%) of the positive donors gave history of Multiple Sexual Partners (MSP).

CONCLUSION

HTLV-1 seroprevalence in Northern Pakistan blood donors was determined to be 0.19%. Large scale studies, including the cost effectiveness of screening blood donations for anti-HTLV-1/2 in Pakistan, are recommended.

Authors+Show Affiliations

Department of Screening, Armed Forces Institute of Transfusion (AFIT), Rawalpindi.Department of Blood Transfusion, Armed Forces Institute of Transfusion (AFIT), Rawalpindi.Department of Blood Transfusion, Armed Forces Institute of Transfusion (AFIT), Rawalpindi.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26691361

Citation

Niazi, Saifullah Khan, et al. "Seroprevalence of Human T-Cell Lymphotropic Virus-1/2 in Blood Donors in Northern Pakistan: Implications for Blood Donor Screening." Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 25, no. 12, 2015, pp. 874-7.
Niazi SK, Bhatti FA, Salamat N. Seroprevalence of Human T-Cell Lymphotropic Virus-1/2 in Blood Donors in Northern Pakistan: Implications for Blood Donor Screening. J Coll Physicians Surg Pak. 2015;25(12):874-7.
Niazi, S. K., Bhatti, F. A., & Salamat, N. (2015). Seroprevalence of Human T-Cell Lymphotropic Virus-1/2 in Blood Donors in Northern Pakistan: Implications for Blood Donor Screening. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 25(12), 874-7. https://doi.org/12.2015/JCPSP.874877
Niazi SK, Bhatti FA, Salamat N. Seroprevalence of Human T-Cell Lymphotropic Virus-1/2 in Blood Donors in Northern Pakistan: Implications for Blood Donor Screening. J Coll Physicians Surg Pak. 2015;25(12):874-7. PubMed PMID: 26691361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprevalence of Human T-Cell Lymphotropic Virus-1/2 in Blood Donors in Northern Pakistan: Implications for Blood Donor Screening. AU - Niazi,Saifullah Khan, AU - Bhatti,Farhat Abbas, AU - Salamat,Nuzhat, PY - 2014/10/19/received PY - 2015/10/12/accepted PY - 2015/12/23/entrez PY - 2015/12/23/pubmed PY - 2016/11/1/medline SP - 874 EP - 7 JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JO - J Coll Physicians Surg Pak VL - 25 IS - 12 N2 - OBJECTIVE: To determine the seroprevalence of Human T-cell Lymphotropic Virus-1/2 (HTLV-1/2) in blood donors in Northern Pakistan. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Armed Forces Institute of Transfusion, Rawalpindi, from July to August 2013. METHODOLOGY: A total of 2100 blood donors were screened for anti-HTLV-1/2 antibodies during the study period, in a pool of six, on a highly sensitive, Chemiluminiscent Microparticle Immunoassay (CMIA) based system. The screening test-reactive donors were recalled, counseled and interviewed, and a fresh sample was obtained for confirmatory testing. Confirmation was performed using additional immunoassays including Line Immunoassay (LIA); with additional testing for HTLV-1 pvDNAPCR. Frequency and percentages were determined. RESULTS: Four donors (0.19%) were repeatedly screening test-reactive and were subsequently confirmed to be HTLV-1 infected by line immunoassay and HTLV-1 pvDNAPCR. All four donors were male with mean age of 27 ± 6.27 years. Two (50%) of the positive donors gave history of Multiple Sexual Partners (MSP). CONCLUSION: HTLV-1 seroprevalence in Northern Pakistan blood donors was determined to be 0.19%. Large scale studies, including the cost effectiveness of screening blood donations for anti-HTLV-1/2 in Pakistan, are recommended. SN - 1681-7168 UR - https://www.unboundmedicine.com/medline/citation/26691361/Seroprevalence_of_Human_T_Cell_Lymphotropic_Virus_1/2_in_Blood_Donors_in_Northern_Pakistan:_Implications_for_Blood_Donor_Screening_ L2 - https://medlineplus.gov/bloodtransfusionanddonation.html DB - PRIME DP - Unbound Medicine ER -