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Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia.
Emerg Infect Dis. 2016 Jan; 22(1):32-40.EI

Abstract

Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is a novel respiratory pathogen first reported in 2012. During September 2014-January 2015, an outbreak of 38 cases of MERS was reported from 4 healthcare facilities in Taif, Saudi Arabia; 21 of the 38 case-patients died. Clinical and public health records showed that 13 patients were healthcare personnel (HCP). Fifteen patients, including 4 HCP, were associated with 1 dialysis unit. Three additional HCP in this dialysis unit had serologic evidence of MERS-CoV infection. Viral RNA was amplified from acute-phase serum specimens of 15 patients, and full spike gene-coding sequencing was obtained from 10 patients who formed a discrete cluster; sequences from specimens of 9 patients were closely related. Similar gene sequences among patients unlinked by time or location suggest unrecognized viral transmission. Circulation persisted in multiple healthcare settings over an extended period, underscoring the importance of strengthening MERS-CoV surveillance and infection-control practices.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

26692003

Citation

Assiri, Abdullah, et al. "Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia." Emerging Infectious Diseases, vol. 22, no. 1, 2016, pp. 32-40.
Assiri A, Abedi GR, Bin Saeed AA, et al. Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia. Emerg Infect Dis. 2016;22(1):32-40.
Assiri, A., Abedi, G. R., Bin Saeed, A. A., Abdalla, M. A., al-Masry, M., Choudhry, A. J., Lu, X., Erdman, D. D., Tatti, K., Binder, A. M., Rudd, J., Tokars, J., Miao, C., Alarbash, H., Nooh, R., Pallansch, M., Gerber, S. I., & Watson, J. T. (2016). Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia. Emerging Infectious Diseases, 22(1), 32-40. https://doi.org/10.3201/eid2201.151370
Assiri A, et al. Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia. Emerg Infect Dis. 2016;22(1):32-40. PubMed PMID: 26692003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia. AU - Assiri,Abdullah, AU - Abedi,Glen R, AU - Bin Saeed,Abdulaziz A, AU - Abdalla,Mutwakil A, AU - al-Masry,Malak, AU - Choudhry,Abdul Jamil, AU - Lu,Xiaoyan, AU - Erdman,Dean D, AU - Tatti,Kathleen, AU - Binder,Alison M, AU - Rudd,Jessica, AU - Tokars,Jerome, AU - Miao,Congrong, AU - Alarbash,Hussain, AU - Nooh,Randa, AU - Pallansch,Mark, AU - Gerber,Susan I, AU - Watson,John T, PY - 2015/12/23/entrez PY - 2015/12/23/pubmed PY - 2016/9/20/medline KW - MERS KW - MERS-CoV KW - Middle East respiratory syndrome KW - Saudi Arabia KW - coronavirus KW - epidemiology KW - genetic sequencing KW - respiratory infections KW - serum KW - viruses SP - 32 EP - 40 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 22 IS - 1 N2 - Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is a novel respiratory pathogen first reported in 2012. During September 2014-January 2015, an outbreak of 38 cases of MERS was reported from 4 healthcare facilities in Taif, Saudi Arabia; 21 of the 38 case-patients died. Clinical and public health records showed that 13 patients were healthcare personnel (HCP). Fifteen patients, including 4 HCP, were associated with 1 dialysis unit. Three additional HCP in this dialysis unit had serologic evidence of MERS-CoV infection. Viral RNA was amplified from acute-phase serum specimens of 15 patients, and full spike gene-coding sequencing was obtained from 10 patients who formed a discrete cluster; sequences from specimens of 9 patients were closely related. Similar gene sequences among patients unlinked by time or location suggest unrecognized viral transmission. Circulation persisted in multiple healthcare settings over an extended period, underscoring the importance of strengthening MERS-CoV surveillance and infection-control practices. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/26692003/Multifacility_Outbreak_of_Middle_East_Respiratory_Syndrome_in_Taif_Saudi_Arabia_ L2 - https://doi.org/10.3201/eid2201.151370 DB - PRIME DP - Unbound Medicine ER -