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Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014.
Emerg Infect Dis. 2016 Jan; 22(1):49-55.EI

Abstract

Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans are incompletely understood. We identified all primary MERS-CoV cases reported in Saudi Arabia during March-November 2014 by excluding those with history of exposure to other cases of MERS-CoV or acute respiratory illness of unknown cause or exposure to healthcare settings within 14 days before illness onset. Using a case-control design, we assessed differences in underlying medical conditions and environmental exposures among primary case-patients and 2-4 controls matched by age, sex, and neighborhood. Using multivariable analysis, we found that direct exposure to dromedary camels during the 2 weeks before illness onset, as well as diabetes mellitus, heart disease, and smoking, were each independently associated with MERS-CoV illness. Further investigation is needed to better understand animal-to-human transmission of MERS-CoV.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26692185

Citation

Alraddadi, Basem M., et al. "Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014." Emerging Infectious Diseases, vol. 22, no. 1, 2016, pp. 49-55.
Alraddadi BM, Watson JT, Almarashi A, et al. Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014. Emerg Infect Dis. 2016;22(1):49-55.
Alraddadi, B. M., Watson, J. T., Almarashi, A., Abedi, G. R., Turkistani, A., Sadran, M., Housa, A., Almazroa, M. A., Alraihan, N., Banjar, A., Albalawi, E., Alhindi, H., Choudhry, A. J., Meiman, J. G., Paczkowski, M., Curns, A., Mounts, A., Feikin, D. R., Marano, N., ... Madani, T. A. (2016). Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014. Emerging Infectious Diseases, 22(1), 49-55. https://doi.org/10.3201/eid2201.151340
Alraddadi BM, et al. Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014. Emerg Infect Dis. 2016;22(1):49-55. PubMed PMID: 26692185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014. AU - Alraddadi,Basem M, AU - Watson,John T, AU - Almarashi,Abdulatif, AU - Abedi,Glen R, AU - Turkistani,Amal, AU - Sadran,Musallam, AU - Housa,Abeer, AU - Almazroa,Mohammad A, AU - Alraihan,Naif, AU - Banjar,Ayman, AU - Albalawi,Eman, AU - Alhindi,Hanan, AU - Choudhry,Abdul Jamil, AU - Meiman,Jonathan G, AU - Paczkowski,Magdalena, AU - Curns,Aaron, AU - Mounts,Anthony, AU - Feikin,Daniel R, AU - Marano,Nina, AU - Swerdlow,David L, AU - Gerber,Susan I, AU - Hajjeh,Rana, AU - Madani,Tariq A, PY - 2015/12/23/entrez PY - 2015/12/23/pubmed PY - 2016/9/20/medline KW - MERS-CoV KW - Middle East respiratory syndrome coronavirus KW - Saudi Arabia KW - case–control study KW - diabetes mellitus KW - dromedary camels KW - heart disease KW - primary infection KW - risk factors KW - smoking KW - transmission KW - viruses KW - zoonosis SP - 49 EP - 55 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 22 IS - 1 N2 - Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans are incompletely understood. We identified all primary MERS-CoV cases reported in Saudi Arabia during March-November 2014 by excluding those with history of exposure to other cases of MERS-CoV or acute respiratory illness of unknown cause or exposure to healthcare settings within 14 days before illness onset. Using a case-control design, we assessed differences in underlying medical conditions and environmental exposures among primary case-patients and 2-4 controls matched by age, sex, and neighborhood. Using multivariable analysis, we found that direct exposure to dromedary camels during the 2 weeks before illness onset, as well as diabetes mellitus, heart disease, and smoking, were each independently associated with MERS-CoV illness. Further investigation is needed to better understand animal-to-human transmission of MERS-CoV. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/26692185/Risk_Factors_for_Primary_Middle_East_Respiratory_Syndrome_Coronavirus_Illness_in_Humans_Saudi_Arabia_2014_ L2 - https://doi.org/10.3201/eid2201.151340 DB - PRIME DP - Unbound Medicine ER -