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Efficacy and safety of pentoxifylline in geriatric patients with intermittent claudication.
Angiology. 1989 Sep; 40(9):795-802.A

Abstract

The effects of pentoxifylline on intermittent claudication were evaluated at a dose of 1200 mg/day in an open-label twelve-week study on geriatric patients with chronic occlusive arterial disease (COAD). Standardized treadmill testing and clinical signs and symptoms of COAD were followed up before and during drug administration. Twenty-four subjects with a mean age of 73.5 years, capable of walking between 20 and 200 meters on the treadmill, were entered into the trial; 22 participated for eight weeks and 19 completed the study in terms of treadmill walking distance measurements at 12 weeks. The mean walking distance for all patients was increased 111% over baseline at week 12. Thirteen subjects were considered drug responders (greater than or equal to 50% increase in treadmill walking distance) and 9 were considered nonresponders (less than 50% increase). Improvements in clinical signs and symptoms of COAD were noted. Decreases in elevated systemic systolic pressures (but not diastolic) were unexpectedly observed in many drug responders. Seven of 19 males reported sexual function improvements while receiving pentoxifylline. Fourteen (58%) of the 24 subjects reported mild side effects of dyspepsia, nausea, vomiting, dizziness, headache, or insomnia; no subjects were withdrawn from the study because of side effects. In summary, pentoxifylline improved function and symptoms in 13 of 22 geriatric patients with intermittent claudication; the drug was safe and well tolerated at the usual dosage in this geriatric patient population.

Authors+Show Affiliations

Pharmacology Research Institute, Long Beach, California.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2669564

Citation

Crowder, J E., et al. "Efficacy and Safety of Pentoxifylline in Geriatric Patients With Intermittent Claudication." Angiology, vol. 40, no. 9, 1989, pp. 795-802.
Crowder JE, Cohn JB, Savitsky JP, et al. Efficacy and safety of pentoxifylline in geriatric patients with intermittent claudication. Angiology. 1989;40(9):795-802.
Crowder, J. E., Cohn, J. B., Savitsky, J. P., Morgan, D. L., Slywka, J., Cobert, B. L., Hryniewicki, S. W., Piccirillo, R. T., & Wilcox, C. S. (1989). Efficacy and safety of pentoxifylline in geriatric patients with intermittent claudication. Angiology, 40(9), 795-802.
Crowder JE, et al. Efficacy and Safety of Pentoxifylline in Geriatric Patients With Intermittent Claudication. Angiology. 1989;40(9):795-802. PubMed PMID: 2669564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of pentoxifylline in geriatric patients with intermittent claudication. AU - Crowder,J E, AU - Cohn,J B, AU - Savitsky,J P, AU - Morgan,D L, AU - Slywka,J, AU - Cobert,B L, AU - Hryniewicki,S W, AU - Piccirillo,R T, AU - Wilcox,C S, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 795 EP - 802 JF - Angiology JO - Angiology VL - 40 IS - 9 N2 - The effects of pentoxifylline on intermittent claudication were evaluated at a dose of 1200 mg/day in an open-label twelve-week study on geriatric patients with chronic occlusive arterial disease (COAD). Standardized treadmill testing and clinical signs and symptoms of COAD were followed up before and during drug administration. Twenty-four subjects with a mean age of 73.5 years, capable of walking between 20 and 200 meters on the treadmill, were entered into the trial; 22 participated for eight weeks and 19 completed the study in terms of treadmill walking distance measurements at 12 weeks. The mean walking distance for all patients was increased 111% over baseline at week 12. Thirteen subjects were considered drug responders (greater than or equal to 50% increase in treadmill walking distance) and 9 were considered nonresponders (less than 50% increase). Improvements in clinical signs and symptoms of COAD were noted. Decreases in elevated systemic systolic pressures (but not diastolic) were unexpectedly observed in many drug responders. Seven of 19 males reported sexual function improvements while receiving pentoxifylline. Fourteen (58%) of the 24 subjects reported mild side effects of dyspepsia, nausea, vomiting, dizziness, headache, or insomnia; no subjects were withdrawn from the study because of side effects. In summary, pentoxifylline improved function and symptoms in 13 of 22 geriatric patients with intermittent claudication; the drug was safe and well tolerated at the usual dosage in this geriatric patient population. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/2669564/Efficacy_and_safety_of_pentoxifylline_in_geriatric_patients_with_intermittent_claudication_ L2 - http://journals.sagepub.com/doi/full/10.1177/000331978904000904?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -