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Effect of feeding whey hydrolysate, soy and conventional cow milk formulas on incidence of atopic disease in high risk infants.
Ann Allergy. 1989 Aug; 63(2):102-6.AA

Abstract

The effect of feeding different infant formulas on incidence of atopic disease was assessed in a prospective double-blind randomized controlled trial among "high risk" infants with family history of atopy among first-degree relatives. The incidence of atopic eczema, wheezing, rhinitis, gastrointestinal symptoms, and colic was noted and serum IgE antibodies to milk were estimated. Seventy-two infants were recruited into each of the following groups: cow milk whey hydrolysate formula (NAN/HA), conventional cow milk formula (Similac), soy-based formula (Isomil), and exclusive breast feeding for greater than or equal to 4 months. The number of infants who exited for reasons other than atopy and were excluded from analysis were 4, 5, 4, and 12 in the four groups, respectively. The incidence of one or more symptoms of possible allergic etiology was five of 68 infants fed NAN/HA, 24 of 67 infants fed Similac, 25 of 68 infants fed Isomil, and 12 of 60 breast-fed infants. Among symptomatic infants, skin prick test to milk proteins was positive in four out of five infants fed NAN/HA, 16 of 24 fed Similac, 2 of 25 fed Isomil, and 7 of 12 breast-fed. IgE antibodies to milk were found in 2 of 68, 9 of 67, 0 of 68, and 6 of 60 infants in the four groups, respectively. It is concluded that exclusive breast feeding for more than 4 months is partially protective against the development of atopic disease among high risk infants.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Pediatrics, Memorial University of Newfoundland, St. John's, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2669565

Citation

Chandra, R K., et al. "Effect of Feeding Whey Hydrolysate, Soy and Conventional Cow Milk Formulas On Incidence of Atopic Disease in High Risk Infants." Annals of Allergy, vol. 63, no. 2, 1989, pp. 102-6.
Chandra RK, Singh G, Shridhara B. Effect of feeding whey hydrolysate, soy and conventional cow milk formulas on incidence of atopic disease in high risk infants. Ann Allergy. 1989;63(2):102-6.
Chandra, R. K., Singh, G., & Shridhara, B. (1989). Effect of feeding whey hydrolysate, soy and conventional cow milk formulas on incidence of atopic disease in high risk infants. Annals of Allergy, 63(2), 102-6.
Chandra RK, Singh G, Shridhara B. Effect of Feeding Whey Hydrolysate, Soy and Conventional Cow Milk Formulas On Incidence of Atopic Disease in High Risk Infants. Ann Allergy. 1989;63(2):102-6. PubMed PMID: 2669565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of feeding whey hydrolysate, soy and conventional cow milk formulas on incidence of atopic disease in high risk infants. AU - Chandra,R K, AU - Singh,G, AU - Shridhara,B, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez KW - Americas KW - Antibodies--analysis KW - Biology KW - Bottle Feeding KW - Breast Feeding KW - Canada KW - Dermatological Effects KW - Developed Countries KW - Diseases KW - Double-blind Studies KW - Examinations And Diagnoses KW - Gastrointestinal Effects KW - Health KW - Immunity KW - Immunologic Factors KW - Incidence KW - Infant Nutrition KW - Laboratory Examinations And Diagnoses KW - Measurement KW - North America KW - Northern America KW - Nutrition KW - Physical Examinations And Diagnoses KW - Physiology KW - Prospective Studies KW - Research Methodology KW - Risk Factors KW - Studies SP - 102 EP - 6 JF - Annals of allergy JO - Ann Allergy VL - 63 IS - 2 N2 - The effect of feeding different infant formulas on incidence of atopic disease was assessed in a prospective double-blind randomized controlled trial among "high risk" infants with family history of atopy among first-degree relatives. The incidence of atopic eczema, wheezing, rhinitis, gastrointestinal symptoms, and colic was noted and serum IgE antibodies to milk were estimated. Seventy-two infants were recruited into each of the following groups: cow milk whey hydrolysate formula (NAN/HA), conventional cow milk formula (Similac), soy-based formula (Isomil), and exclusive breast feeding for greater than or equal to 4 months. The number of infants who exited for reasons other than atopy and were excluded from analysis were 4, 5, 4, and 12 in the four groups, respectively. The incidence of one or more symptoms of possible allergic etiology was five of 68 infants fed NAN/HA, 24 of 67 infants fed Similac, 25 of 68 infants fed Isomil, and 12 of 60 breast-fed infants. Among symptomatic infants, skin prick test to milk proteins was positive in four out of five infants fed NAN/HA, 16 of 24 fed Similac, 2 of 25 fed Isomil, and 7 of 12 breast-fed. IgE antibodies to milk were found in 2 of 68, 9 of 67, 0 of 68, and 6 of 60 infants in the four groups, respectively. It is concluded that exclusive breast feeding for more than 4 months is partially protective against the development of atopic disease among high risk infants.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0003-4738 UR - https://www.unboundmedicine.com/medline/citation/2669565/Effect_of_feeding_whey_hydrolysate_soy_and_conventional_cow_milk_formulas_on_incidence_of_atopic_disease_in_high_risk_infants_ L2 - https://medlineplus.gov/foodallergy.html DB - PRIME DP - Unbound Medicine ER -