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Effects of modest doses of omega-3 fatty acids on lipids and lipoproteins in hypertriglyceridemic subjects. A randomized controlled trial.
Arch Intern Med 1989; 149(8):1857-62AI

Abstract

Unlike the well-established hypotriglyceridemic effect of omega-3 fatty acid supplementation, the influence of more clinically tolerable doses on lipoproteins and apolipoproteins is less well characterized. Therefore, we compared the relative effects of modest doses of omega-3 fatty acid supplementation with a corn oil control on lipids, lipoproteins, and apolipoproteins in a randomized, double-blind controlled crossover study. Eight hypertriglyceridemic subjects ingested 4.6 g/d of omega-3 fatty acids or 5.4 g/d of linoleic acid (supplied as corn oil) for 8 weeks, then crossed over to the alternative encapsulated oil for another 8 weeks, following an interposed 4-week wash-out period. Compared with the corn oil control, fish oil supplementation caused a significant reduction in triglyceride levels by a mean of 2.21 mmol/L and increased the high-density lipoprotein cholesterol by a mean of 0.13 mmol/L, associated with a significant rise in the high-density lipoprotein 3 subfraction. Furthermore, there was a significant increase in low-density lipoprotein (LDL) apolipoprotein B levels by a mean of 0.246 g/L. Compared with corn oil, no statistically significant change for LDL cholesterol or other apolipoprotein levels occurred, although LDL cholesterol showed a mild elevation. These data suggest that unlike large doses of omega-3 fatty acids, the hypotriglyceridemic effect of modest amounts of encapsulated fish oil supplementation is unaccompanied by favorable changes in LDL cholesterol or LDL apolipoprotein B levels; the potential therapeutic usefulness of modest doses of dietary fish oil for the treatment of hypertriglyceridemia, therefore, may be limited.

Authors+Show Affiliations

Department of Pharmacy, University Hospital, University of Cincinnati, Ohio.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2669667

Citation

Deck, C, and K Radack. "Effects of Modest Doses of Omega-3 Fatty Acids On Lipids and Lipoproteins in Hypertriglyceridemic Subjects. a Randomized Controlled Trial." Archives of Internal Medicine, vol. 149, no. 8, 1989, pp. 1857-62.
Deck C, Radack K. Effects of modest doses of omega-3 fatty acids on lipids and lipoproteins in hypertriglyceridemic subjects. A randomized controlled trial. Arch Intern Med. 1989;149(8):1857-62.
Deck, C., & Radack, K. (1989). Effects of modest doses of omega-3 fatty acids on lipids and lipoproteins in hypertriglyceridemic subjects. A randomized controlled trial. Archives of Internal Medicine, 149(8), pp. 1857-62.
Deck C, Radack K. Effects of Modest Doses of Omega-3 Fatty Acids On Lipids and Lipoproteins in Hypertriglyceridemic Subjects. a Randomized Controlled Trial. Arch Intern Med. 1989;149(8):1857-62. PubMed PMID: 2669667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of modest doses of omega-3 fatty acids on lipids and lipoproteins in hypertriglyceridemic subjects. A randomized controlled trial. AU - Deck,C, AU - Radack,K, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez SP - 1857 EP - 62 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 149 IS - 8 N2 - Unlike the well-established hypotriglyceridemic effect of omega-3 fatty acid supplementation, the influence of more clinically tolerable doses on lipoproteins and apolipoproteins is less well characterized. Therefore, we compared the relative effects of modest doses of omega-3 fatty acid supplementation with a corn oil control on lipids, lipoproteins, and apolipoproteins in a randomized, double-blind controlled crossover study. Eight hypertriglyceridemic subjects ingested 4.6 g/d of omega-3 fatty acids or 5.4 g/d of linoleic acid (supplied as corn oil) for 8 weeks, then crossed over to the alternative encapsulated oil for another 8 weeks, following an interposed 4-week wash-out period. Compared with the corn oil control, fish oil supplementation caused a significant reduction in triglyceride levels by a mean of 2.21 mmol/L and increased the high-density lipoprotein cholesterol by a mean of 0.13 mmol/L, associated with a significant rise in the high-density lipoprotein 3 subfraction. Furthermore, there was a significant increase in low-density lipoprotein (LDL) apolipoprotein B levels by a mean of 0.246 g/L. Compared with corn oil, no statistically significant change for LDL cholesterol or other apolipoprotein levels occurred, although LDL cholesterol showed a mild elevation. These data suggest that unlike large doses of omega-3 fatty acids, the hypotriglyceridemic effect of modest amounts of encapsulated fish oil supplementation is unaccompanied by favorable changes in LDL cholesterol or LDL apolipoprotein B levels; the potential therapeutic usefulness of modest doses of dietary fish oil for the treatment of hypertriglyceridemia, therefore, may be limited. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/2669667/Effects_of_modest_doses_of_omega_3_fatty_acids_on_lipids_and_lipoproteins_in_hypertriglyceridemic_subjects__A_randomized_controlled_trial_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/149/pg/1857 DB - PRIME DP - Unbound Medicine ER -