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Clinical features, microbiological profiles and treatment outcome of lacrimal plug-related canaliculitis compared with those of primary canaliculitis.
Br J Ophthalmol. 2016 Sep; 100(9):1285-9.BJ

Abstract

AIMS

To compare the clinical features and treatment outcome between lacrimal plug-related canaliculitis and primary canaliculitis.

METHODS

Patients with plug-related canaliculitis and primary canaliculitis between 2007 and 2014 in a medical centre were collected. Charts were reviewed for clinical features, microbiological profiles, time lapse between plug insertion and symptom onset, type of plug and outcomes.

RESULTS

Of 76 eligible cases collected, 13 were plug-related canaliculitis and 63 were primary canaliculitis. The most common presenting symptom was discharge in both groups (85% and 79%, respectively). The average time interval from plug insertion to symptoms onset was 5.5 years. Most canaliculitis developed in women, especially for plug-related canaliculitis, when compared with primary canaliculitis (100% vs 65.1%; p=0.015). The most common isolated microorganism was Pseudomonas aeruginosa in plug-related canaliculitis (46%) and Streptococcus in primary canaliculitis (28%), respectively. Isolation of Pseudomonas was significantly higher in plug-related canaliculitis than in primary canaliculitis (46% vs 12%; p=0.029). Most plug-related canaliculitis resolved after removal of plugs by canaliculotomy (12 cases, 93%). Most identified plug was SmartPlug (seven cases), followed by EaglePlug (two cases) and Herrick Lacrimal Plug (two cases). There was no recurrence in patients with plug-related canaliculitis, however, recurrence developed in seven patients (11%) with primary canaliculitis.

CONCLUSIONS

In comparison with primary canaliculitis, plug-related canaliculitis appear to be more prevalent in women and show a different microbiological profile. Retrieval of infected plug by canaliculotomy and adequate antibiotics can achieve a good outcome. Long-term follow-up is required because canaliculitis may develop several years after plug insertion.

Authors+Show Affiliations

Department of Ophthalmology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.Department of Ophthalmology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.Department of Ophthalmology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.Department of Ophthalmology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.Department of Ophthalmology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.Department of Ophthalmology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26701689

Citation

Huang, Yu-Yun, et al. "Clinical Features, Microbiological Profiles and Treatment Outcome of Lacrimal Plug-related Canaliculitis Compared With Those of Primary Canaliculitis." The British Journal of Ophthalmology, vol. 100, no. 9, 2016, pp. 1285-9.
Huang YY, Yu WK, Tsai CC, et al. Clinical features, microbiological profiles and treatment outcome of lacrimal plug-related canaliculitis compared with those of primary canaliculitis. Br J Ophthalmol. 2016;100(9):1285-9.
Huang, Y. Y., Yu, W. K., Tsai, C. C., Kao, S. C., Kau, H. C., & Liu, C. J. (2016). Clinical features, microbiological profiles and treatment outcome of lacrimal plug-related canaliculitis compared with those of primary canaliculitis. The British Journal of Ophthalmology, 100(9), 1285-9. https://doi.org/10.1136/bjophthalmol-2015-307500
Huang YY, et al. Clinical Features, Microbiological Profiles and Treatment Outcome of Lacrimal Plug-related Canaliculitis Compared With Those of Primary Canaliculitis. Br J Ophthalmol. 2016;100(9):1285-9. PubMed PMID: 26701689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features, microbiological profiles and treatment outcome of lacrimal plug-related canaliculitis compared with those of primary canaliculitis. AU - Huang,Yu-Yun, AU - Yu,Wei-Kuang, AU - Tsai,Chieh-Chih, AU - Kao,Shu-Ching, AU - Kau,Hui-Chuan, AU - Liu,Catherine Jui-Ling, Y1 - 2015/12/23/ PY - 2015/07/16/received PY - 2015/11/22/accepted PY - 2015/12/25/entrez PY - 2015/12/25/pubmed PY - 2017/5/13/medline KW - Infection KW - Lacrimal drainage KW - Microbiology KW - Tears SP - 1285 EP - 9 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 100 IS - 9 N2 - AIMS: To compare the clinical features and treatment outcome between lacrimal plug-related canaliculitis and primary canaliculitis. METHODS: Patients with plug-related canaliculitis and primary canaliculitis between 2007 and 2014 in a medical centre were collected. Charts were reviewed for clinical features, microbiological profiles, time lapse between plug insertion and symptom onset, type of plug and outcomes. RESULTS: Of 76 eligible cases collected, 13 were plug-related canaliculitis and 63 were primary canaliculitis. The most common presenting symptom was discharge in both groups (85% and 79%, respectively). The average time interval from plug insertion to symptoms onset was 5.5 years. Most canaliculitis developed in women, especially for plug-related canaliculitis, when compared with primary canaliculitis (100% vs 65.1%; p=0.015). The most common isolated microorganism was Pseudomonas aeruginosa in plug-related canaliculitis (46%) and Streptococcus in primary canaliculitis (28%), respectively. Isolation of Pseudomonas was significantly higher in plug-related canaliculitis than in primary canaliculitis (46% vs 12%; p=0.029). Most plug-related canaliculitis resolved after removal of plugs by canaliculotomy (12 cases, 93%). Most identified plug was SmartPlug (seven cases), followed by EaglePlug (two cases) and Herrick Lacrimal Plug (two cases). There was no recurrence in patients with plug-related canaliculitis, however, recurrence developed in seven patients (11%) with primary canaliculitis. CONCLUSIONS: In comparison with primary canaliculitis, plug-related canaliculitis appear to be more prevalent in women and show a different microbiological profile. Retrieval of infected plug by canaliculotomy and adequate antibiotics can achieve a good outcome. Long-term follow-up is required because canaliculitis may develop several years after plug insertion. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/26701689/Clinical_features_microbiological_profiles_and_treatment_outcome_of_lacrimal_plug_related_canaliculitis_compared_with_those_of_primary_canaliculitis_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=26701689 DB - PRIME DP - Unbound Medicine ER -