Tags

Type your tag names separated by a space and hit enter

Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo.
Biochim Biophys Acta 2016; 1862(5):975-82BB

Abstract

BACKGROUND

Vascular contributions to cognitive impairment and dementia (VCID) is a complex form of dementia, combining aspects of vascular disease and other forms of dementia, such as Alzheimer's disease. VCID encompasses a wide spectrum of cerebrovascular-driven cognitive impairment, from mild cognitive impairment to fully developed dementia. This disease state is further complicated by metabolic disorders, such as type 2 diabetes and hypertension, and lifestyle factors, like obesity and high fat diets.

SCOPE OF REVIEW

This manuscript is meant to both define VCID and review the in vitro and in vivo models of the disease state. This includes in vitro models of the neurovascular unit, models of chronic cerebral hypoperfusion, animals with NOTCH3 mutations as a model of small vessel disease, large animals with cerebral amyloid angiopathy (CAA), and animal models of mixed dementia.

MAJOR CONCLUSIONS

Synthetic microvessels are a promising technique to study the neurovascular unit and canines, despite the cost, are an excellent model to study CAA. While there are several good models of individual aspects of VCID, the heterogeneity of the disease states prevents them from being a model of all aspects of the disease. Therefore, VCID needs to be further defined into disease states that exist within this umbrella term. This includes specific guidelines for stroke counts and stroke locations and further categorization of overlapping cerebrovascular and AD pathologies that contribute to dementia. This will allow for better models and a more thorough understanding of how vascular disease contributes to dementia.

GENERAL SIGNIFICANCE

VCID is the second most common form of dementia and is expected to increase in coming years. The heterogeneity of VCID makes it difficult to study, but without better definitions and models, VCID presents a major public health problem for our aging population. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia, edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

Authors+Show Affiliations

Department of Molecular and Cellular Biochemistry, University of Kentucky, 800 South Limestone, Lexington, KY 40536, USA; Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone, Lexington, KY 40536, USA.Department of Molecular and Cellular Biochemistry, University of Kentucky, 800 South Limestone, Lexington, KY 40536, USA; Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone, Lexington, KY 40536, USA. Electronic address: Michael.Murphy@uky.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26704178

Citation

Helman, Alex M., and M Paul Murphy. "Vascular Cognitive Impairment: Modeling a Critical Neurologic Disease in Vitro and in Vivo." Biochimica Et Biophysica Acta, vol. 1862, no. 5, 2016, pp. 975-82.
Helman AM, Murphy MP. Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo. Biochim Biophys Acta. 2016;1862(5):975-82.
Helman, A. M., & Murphy, M. P. (2016). Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo. Biochimica Et Biophysica Acta, 1862(5), pp. 975-82. doi:10.1016/j.bbadis.2015.12.009.
Helman AM, Murphy MP. Vascular Cognitive Impairment: Modeling a Critical Neurologic Disease in Vitro and in Vivo. Biochim Biophys Acta. 2016;1862(5):975-82. PubMed PMID: 26704178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo. AU - Helman,Alex M, AU - Murphy,M Paul, Y1 - 2015/12/17/ PY - 2015/09/03/received PY - 2015/12/04/revised PY - 2015/12/07/accepted PY - 2015/12/26/entrez PY - 2015/12/26/pubmed PY - 2019/1/25/medline KW - VCI KW - VCID KW - Vascular cognitive impairment KW - Vascular contributions to cognitive impairment and dementia SP - 975 EP - 82 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1862 IS - 5 N2 - BACKGROUND: Vascular contributions to cognitive impairment and dementia (VCID) is a complex form of dementia, combining aspects of vascular disease and other forms of dementia, such as Alzheimer's disease. VCID encompasses a wide spectrum of cerebrovascular-driven cognitive impairment, from mild cognitive impairment to fully developed dementia. This disease state is further complicated by metabolic disorders, such as type 2 diabetes and hypertension, and lifestyle factors, like obesity and high fat diets. SCOPE OF REVIEW: This manuscript is meant to both define VCID and review the in vitro and in vivo models of the disease state. This includes in vitro models of the neurovascular unit, models of chronic cerebral hypoperfusion, animals with NOTCH3 mutations as a model of small vessel disease, large animals with cerebral amyloid angiopathy (CAA), and animal models of mixed dementia. MAJOR CONCLUSIONS: Synthetic microvessels are a promising technique to study the neurovascular unit and canines, despite the cost, are an excellent model to study CAA. While there are several good models of individual aspects of VCID, the heterogeneity of the disease states prevents them from being a model of all aspects of the disease. Therefore, VCID needs to be further defined into disease states that exist within this umbrella term. This includes specific guidelines for stroke counts and stroke locations and further categorization of overlapping cerebrovascular and AD pathologies that contribute to dementia. This will allow for better models and a more thorough understanding of how vascular disease contributes to dementia. GENERAL SIGNIFICANCE: VCID is the second most common form of dementia and is expected to increase in coming years. The heterogeneity of VCID makes it difficult to study, but without better definitions and models, VCID presents a major public health problem for our aging population. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia, edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/26704178/Vascular_cognitive_impairment:_Modeling_a_critical_neurologic_disease_in_vitro_and_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4439(15)00363-4 DB - PRIME DP - Unbound Medicine ER -