Tags

Type your tag names separated by a space and hit enter

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats.
Pharm Biol. 2016 Sep; 54(9):1716-26.PB

Abstract

Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant activities of ethanol extract of S. densiflorum (EFSD) fruits in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. Materials and methods Acute oral toxicity and oral glucose tolerance were assessed in normal rats. The antidiabetic, antihyperlipidaemic and antioxidant activities were investigated in STZ - NA-induced diabetic rats. Diabetic rats were orally administered with glibenclamide (10 mg/kg b.wt), EFSD (200, 400 and 800 mg/kg b.wt) for 28 d. Further, changes in the blood glucose level (BGL), biochemical parameters, antioxidants were observed and histology of pancreas was performed. Results No toxicity and lethality were observed. Results of the following parameters are represented by treated versus disease control (STZ + NA) groups. BGL (161.33 ± 22.8 versus 476.17 ± 56.58 mg/dl), glycosylated haemoglobin (5.285 ± 0.19 versus 8.05 ± 0.55%), urea (40.32 ± 1.96 versus 75.37 ± 2.91 mg/dl), uric acid (1.2 ± 0.07 versus 2.16 ± 0.05 mg/dl), total cholesterol (89.3 ± 5.14 versus 139.7 ± 5.95 mg/dl) and triglycerides (79.65 ± 2.52 versus 108.9 ± 3.61 mg/dl) were significantly decreased, whereas haemoglobin (11.75 ± 0.73 versus 7.95 ± 0.42 g/dl), high-density lipoprotein cholesterol (14.2 ± 1.11 versus 6.97 ± 0.84 mg/dl), total protein (45%) and liver glycogen (87%) were significantly increased in EFSD-treated diabetic group. Significant changes were observed in the enzymatic and non-enzymatic antioxidants in EFSD-treated groups (p < 0.001). Histopathological examination showed the regeneration of β-cells in Islets of Langerhans. Conclusion This study confirms the antidiabetic, antihyperlipidaemic and antioxidant activities of S. densiflorum fruits.

Authors+Show Affiliations

a Department of Bioinformatics , Science Block, Alagappa University , Karaikudi , Tamil Nadu , India ;a Department of Bioinformatics , Science Block, Alagappa University , Karaikudi , Tamil Nadu , India ;b Central Animal House Facility, SASTRA University , Thanjavur , Tamil Nadu , India ;c Organic Synthesis Group, Department of Chemistry , School of Chemical and Biotechnology, SASTRA University , Thanjavur , Tamil Nadu , India.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26704340

Citation

Krishnasamy, Gopinath, et al. "Antidiabetic, Antihyperlipidaemic, and Antioxidant Activity of Syzygium Densiflorum Fruits in Streptozotocin and Nicotinamide-induced Diabetic Rats." Pharmaceutical Biology, vol. 54, no. 9, 2016, pp. 1716-26.
Krishnasamy G, Muthusamy K, Chellappan DR, et al. Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats. Pharm Biol. 2016;54(9):1716-26.
Krishnasamy, G., Muthusamy, K., Chellappan, D. R., & Subbiah, N. (2016). Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats. Pharmaceutical Biology, 54(9), 1716-26. https://doi.org/10.3109/13880209.2015.1125932
Krishnasamy G, et al. Antidiabetic, Antihyperlipidaemic, and Antioxidant Activity of Syzygium Densiflorum Fruits in Streptozotocin and Nicotinamide-induced Diabetic Rats. Pharm Biol. 2016;54(9):1716-26. PubMed PMID: 26704340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats. AU - Krishnasamy,Gopinath, AU - Muthusamy,Karthikeyan, AU - Chellappan,David Raj, AU - Subbiah,Nagarajan, Y1 - 2015/12/24/ PY - 2015/12/26/entrez PY - 2015/12/26/pubmed PY - 2017/2/14/medline KW - blood glucose level KW - diabetes induction KW - diabetes mellitus KW - medicinal plant KW - β-Cell restoration SP - 1716 EP - 26 JF - Pharmaceutical biology JO - Pharm Biol VL - 54 IS - 9 N2 - Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant activities of ethanol extract of S. densiflorum (EFSD) fruits in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. Materials and methods Acute oral toxicity and oral glucose tolerance were assessed in normal rats. The antidiabetic, antihyperlipidaemic and antioxidant activities were investigated in STZ - NA-induced diabetic rats. Diabetic rats were orally administered with glibenclamide (10 mg/kg b.wt), EFSD (200, 400 and 800 mg/kg b.wt) for 28 d. Further, changes in the blood glucose level (BGL), biochemical parameters, antioxidants were observed and histology of pancreas was performed. Results No toxicity and lethality were observed. Results of the following parameters are represented by treated versus disease control (STZ + NA) groups. BGL (161.33 ± 22.8 versus 476.17 ± 56.58 mg/dl), glycosylated haemoglobin (5.285 ± 0.19 versus 8.05 ± 0.55%), urea (40.32 ± 1.96 versus 75.37 ± 2.91 mg/dl), uric acid (1.2 ± 0.07 versus 2.16 ± 0.05 mg/dl), total cholesterol (89.3 ± 5.14 versus 139.7 ± 5.95 mg/dl) and triglycerides (79.65 ± 2.52 versus 108.9 ± 3.61 mg/dl) were significantly decreased, whereas haemoglobin (11.75 ± 0.73 versus 7.95 ± 0.42 g/dl), high-density lipoprotein cholesterol (14.2 ± 1.11 versus 6.97 ± 0.84 mg/dl), total protein (45%) and liver glycogen (87%) were significantly increased in EFSD-treated diabetic group. Significant changes were observed in the enzymatic and non-enzymatic antioxidants in EFSD-treated groups (p < 0.001). Histopathological examination showed the regeneration of β-cells in Islets of Langerhans. Conclusion This study confirms the antidiabetic, antihyperlipidaemic and antioxidant activities of S. densiflorum fruits. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/26704340/Antidiabetic_antihyperlipidaemic_and_antioxidant_activity_of_Syzygium_densiflorum_fruits_in_streptozotocin_and_nicotinamide_induced_diabetic_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2015.1125932 DB - PRIME DP - Unbound Medicine ER -