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Safety of a thickened extensive casein hydrolysate formula.
Nutrition. 2016 Feb; 32(2):206-12.N

Abstract

OBJECTIVES

Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA.

METHODS

Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF.

RESULTS

A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study.

CONCLUSIONS

The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.

Authors+Show Affiliations

UZ Brussel, Department of Pediatrics, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: yvan.vandenplas@uzbrussel.be.UZ Brussel, Department of Pediatrics, Vrije Universiteit Brussel, Brussels, Belgium.Department of Pediatrics, Hippocration Hospital, Thessaloniki, Greece.Department of Pediatrics, Hippocration Hospital, Thessaloniki, Greece.Department of Pediatrics, Hippocration Hospital, Thessaloniki, Greece.Faculty of Medicine, Department of Pediatrics, Kuwait University, Kuwait City, Kuwait.Faculty of Medicine, Department of Pediatrics, Kuwait University, Kuwait City, Kuwait.Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.Tripoli, Lebanon.University Children's Hospital, Ljubljana, Slovenia.University of Balamand, Beirut, Lebanon.Department of Pediatrics, La Citadelle Regional Hospital, Liège, Belgium.Department of Pediatrics, La Citadelle Regional Hospital, Liège, Belgium.Beirut, Lebanon.Mount Lebanon Hospital, Beyruth, Lebanon.Bahman Hospital, Medical Director Dar Hawraa Center, Beyruth, Lebanon.Department of Pediatrics, Regional Hospital, Namur, Belgium.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26704966

Citation

Vandenplas, Yvan, et al. "Safety of a Thickened Extensive Casein Hydrolysate Formula." Nutrition (Burbank, Los Angeles County, Calif.), vol. 32, no. 2, 2016, pp. 206-12.
Vandenplas Y, De Greef E, Xinias I, et al. Safety of a thickened extensive casein hydrolysate formula. Nutrition. 2016;32(2):206-12.
Vandenplas, Y., De Greef, E., Xinias, I., Vrani, O., Mavroudi, A., Hammoud, M., Al Refai, F., Khalife, M. C., Sayad, A., Noun, P., Farah, A., Makhoul, G., Orel, R., Sokhn, M., L'Homme, A., Mohring, M. P., Merhi, B. A., Boulos, J., El Masri, H., & Halut, C. (2016). Safety of a thickened extensive casein hydrolysate formula. Nutrition (Burbank, Los Angeles County, Calif.), 32(2), 206-12. https://doi.org/10.1016/j.nut.2015.08.008
Vandenplas Y, et al. Safety of a Thickened Extensive Casein Hydrolysate Formula. Nutrition. 2016;32(2):206-12. PubMed PMID: 26704966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety of a thickened extensive casein hydrolysate formula. AU - Vandenplas,Yvan, AU - De Greef,Elisabeth, AU - Xinias,I, AU - Vrani,O, AU - Mavroudi,A, AU - Hammoud,M, AU - Al Refai,F, AU - Khalife,M C, AU - Sayad,A, AU - Noun,P, AU - Farah,A, AU - Makhoul,G, AU - Orel,R, AU - Sokhn,M, AU - L'Homme,A, AU - Mohring,M P, AU - Merhi,B Abou, AU - Boulos,J, AU - El Masri,H, AU - Halut,C, AU - ,, Y1 - 2015/09/02/ PY - 2015/04/06/received PY - 2015/07/14/revised PY - 2015/08/08/accepted PY - 2015/12/26/entrez PY - 2015/12/26/pubmed PY - 2016/12/16/medline KW - (Extensive) hydrolysate KW - Antiregurgitation formula KW - Cow's milk allergy KW - Infant nutrition KW - Thickened formula SP - 206 EP - 12 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 32 IS - 2 N2 - OBJECTIVES: Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA. METHODS: Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF. RESULTS: A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study. CONCLUSIONS: The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/26704966/Safety_of_a_thickened_extensive_casein_hydrolysate_formula_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(15)00343-3 DB - PRIME DP - Unbound Medicine ER -