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Safety of a thickened extensive casein hydrolysate formula.
Nutrition. 2016 Feb; 32(2):206-12.N

Abstract

OBJECTIVES

Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA.

METHODS

Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF.

RESULTS

A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study.

CONCLUSIONS

The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.

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Authors+Show Affiliations

Vandenplas Y
UZ Brussel, Department of Pediatrics, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: yvan.vandenplas@uzbrussel.be.
De Greef E
UZ Brussel, Department of Pediatrics, Vrije Universiteit Brussel, Brussels, Belgium.
Xinias I
Department of Pediatrics, Hippocration Hospital, Thessaloniki, Greece.
Vrani O
Department of Pediatrics, Hippocration Hospital, Thessaloniki, Greece.
Mavroudi A
Department of Pediatrics, Hippocration Hospital, Thessaloniki, Greece.
Hammoud M
Faculty of Medicine, Department of Pediatrics, Kuwait University, Kuwait City, Kuwait.
Al Refai F
Faculty of Medicine, Department of Pediatrics, Kuwait University, Kuwait City, Kuwait.
Khalife MC
Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.
Sayad A
Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.
Noun P
Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.
Farah A
Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.
Makhoul G
Tripoli, Lebanon.
Orel R
University Children's Hospital, Ljubljana, Slovenia.
Sokhn M
University of Balamand, Beirut, Lebanon.
L'Homme A
Department of Pediatrics, La Citadelle Regional Hospital, Liège, Belgium.
Mohring MP
Department of Pediatrics, La Citadelle Regional Hospital, Liège, Belgium.
Merhi BA
Beirut, Lebanon.
Boulos J
Mount Lebanon Hospital, Beyruth, Lebanon.
El Masri H
Bahman Hospital, Medical Director Dar Hawraa Center, Beyruth, Lebanon.
Halut C
Department of Pediatrics, Regional Hospital, Namur, Belgium.
Allar Study Group
No affiliation info available

MeSH

AnimalsBody HeightBody WeightCaseinsChild DevelopmentDietary CarbohydratesDietary FatsDietary FiberDietary ProteinsDouble-Blind MethodEnergy IntakeFemaleHumansImmunoglobulin EInfantInfant FormulaLaryngopharyngeal RefluxMaleMilkMilk HypersensitivityProspective StudiesProtein HydrolysatesViscosity

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26704966

Citation

Vandenplas, Yvan, et al. "Safety of a Thickened Extensive Casein Hydrolysate Formula." Nutrition (Burbank, Los Angeles County, Calif.), vol. 32, no. 2, 2016, pp. 206-12.
Vandenplas Y, De Greef E, Xinias I, et al. Safety of a thickened extensive casein hydrolysate formula. Nutrition. 2016;32(2):206-12.
Vandenplas, Y., De Greef, E., Xinias, I., Vrani, O., Mavroudi, A., Hammoud, M., Al Refai, F., Khalife, M. C., Sayad, A., Noun, P., Farah, A., Makhoul, G., Orel, R., Sokhn, M., L'Homme, A., Mohring, M. P., Merhi, B. A., Boulos, J., El Masri, H., & Halut, C. (2016). Safety of a thickened extensive casein hydrolysate formula. Nutrition (Burbank, Los Angeles County, Calif.), 32(2), 206-12. https://doi.org/10.1016/j.nut.2015.08.008
Vandenplas Y, et al. Safety of a Thickened Extensive Casein Hydrolysate Formula. Nutrition. 2016;32(2):206-12. PubMed PMID: 26704966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety of a thickened extensive casein hydrolysate formula. AU - Vandenplas,Yvan, AU - De Greef,Elisabeth, AU - Xinias,I, AU - Vrani,O, AU - Mavroudi,A, AU - Hammoud,M, AU - Al Refai,F, AU - Khalife,M C, AU - Sayad,A, AU - Noun,P, AU - Farah,A, AU - Makhoul,G, AU - Orel,R, AU - Sokhn,M, AU - L'Homme,A, AU - Mohring,M P, AU - Merhi,B Abou, AU - Boulos,J, AU - El Masri,H, AU - Halut,C, AU - ,, Y1 - 2015/09/02/ PY - 2015/04/06/received PY - 2015/07/14/revised PY - 2015/08/08/accepted PY - 2015/12/26/entrez PY - 2015/12/26/pubmed PY - 2016/12/16/medline KW - (Extensive) hydrolysate KW - Antiregurgitation formula KW - Cow's milk allergy KW - Infant nutrition KW - Thickened formula SP - 206 EP - 12 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 32 IS - 2 N2 - OBJECTIVES: Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA. METHODS: Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF. RESULTS: A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study. CONCLUSIONS: The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/26704966/Safety_of_a_thickened_extensive_casein_hydrolysate_formula_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(15)00343-3 DB - PRIME DP - Unbound Medicine ER -