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Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease.
Biochim Biophys Acta 2016; 1862(5):887-900BB

Abstract

Vascular insults can initiate a cascade of molecular events leading to neurodegeneration, cognitive impairment, and dementia. Here, we review the cellular and molecular mechanisms in cerebral blood vessels and the pathophysiological events leading to cerebral blood flow dysregulation and disruption of the neurovascular unit and the blood-brain barrier, which all may contribute to the onset and progression of dementia and Alzheimer's disease (AD). Particularly, we examine the link between neurovascular dysfunction and neurodegeneration including the effects of AD genetic risk factors on cerebrovascular functions and clearance of Alzheimer's amyloid-β peptide toxin, and the impact of vascular risk factors, environment, and lifestyle on cerebral blood vessels, which in turn may affect synaptic, neuronal, and cognitive functions. Finally, we examine potential experimental treatments for dementia and AD based on the neurovascular model, and discuss some critical questions to be addressed by future studies. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

Authors+Show Affiliations

Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA.Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA.Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA.Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA. Electronic address: zlokovic@usc.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26705676

Citation

Nelson, Amy R., et al. "Neurovascular Dysfunction and Neurodegeneration in Dementia and Alzheimer's Disease." Biochimica Et Biophysica Acta, vol. 1862, no. 5, 2016, pp. 887-900.
Nelson AR, Sweeney MD, Sagare AP, et al. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta. 2016;1862(5):887-900.
Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2016). Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochimica Et Biophysica Acta, 1862(5), pp. 887-900. doi:10.1016/j.bbadis.2015.12.016.
Nelson AR, et al. Neurovascular Dysfunction and Neurodegeneration in Dementia and Alzheimer's Disease. Biochim Biophys Acta. 2016;1862(5):887-900. PubMed PMID: 26705676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. AU - Nelson,Amy R, AU - Sweeney,Melanie D, AU - Sagare,Abhay P, AU - Zlokovic,Berislav V, Y1 - 2015/12/17/ PY - 2015/10/14/received PY - 2015/12/10/revised PY - 2015/12/10/accepted PY - 2015/12/27/entrez PY - 2015/12/27/pubmed PY - 2019/1/25/medline KW - Alzheimer's disease KW - Blood–brain barrier KW - Dementia KW - Neurovascular medicine KW - Neurovascular unit KW - Vascular factors SP - 887 EP - 900 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1862 IS - 5 N2 - Vascular insults can initiate a cascade of molecular events leading to neurodegeneration, cognitive impairment, and dementia. Here, we review the cellular and molecular mechanisms in cerebral blood vessels and the pathophysiological events leading to cerebral blood flow dysregulation and disruption of the neurovascular unit and the blood-brain barrier, which all may contribute to the onset and progression of dementia and Alzheimer's disease (AD). Particularly, we examine the link between neurovascular dysfunction and neurodegeneration including the effects of AD genetic risk factors on cerebrovascular functions and clearance of Alzheimer's amyloid-β peptide toxin, and the impact of vascular risk factors, environment, and lifestyle on cerebral blood vessels, which in turn may affect synaptic, neuronal, and cognitive functions. Finally, we examine potential experimental treatments for dementia and AD based on the neurovascular model, and discuss some critical questions to be addressed by future studies. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/26705676/Neurovascular_dysfunction_and_neurodegeneration_in_dementia_and_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4439(15)00370-1 DB - PRIME DP - Unbound Medicine ER -