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CKD and Health-Related Quality of Life: The Korea National Health and Nutrition Examination Survey.
Am J Kidney Dis. 2016 06; 67(6):851-60.AJ

Abstract

BACKGROUND

Quality of life is increasingly viewed as an important health outcome. However, the association of chronic kidney disease (CKD) and its severity with health-related quality of life is uncertain.

STUDY DESIGN

Nationwide population-based cross-sectional study.

SETTING & PARTICIPANTS

46,676 adults participating in the Korea National Health and Nutrition Examination Survey (KNHANES) 2005 to 2013.

PREDICTOR

CKD ascertained as dipstick-positive proteinuria or estimated glomerular filtration rate (eGFR)<60mL/min/1.73m(2). 5 eGFR categories of CKD were compared: ≥90 (with proteinuria), 60 to 89 (with proteinuria), 45 to 59, 30 to 44, and <30mL/min/1.73m(2).

OUTCOMES

The EQ-5D index for health status (range, 0 [death] to 1 [optimal health]).

RESULTS

The total crude CKD prevalence estimate for adults 20 years or older in Korea was 5.5%. After adjustments for age, sex, risk factors, and comorbid conditions, the EQ-5D index was lower in those with versus without CKD, with mean differences of -0.004 (95% CI, -0.015 to 0.007), -0.016 (95% CI, -0.032 to -0.000), -0.020 (95% CI, -0.029 to -0.011), -0.052 (95% CI, -0.072 to -0.032), and -0.067 (95% CI, -0.101 to -0.032), respectively, for CKD eGFR categories of ≥90, 60 to 89, 45 to 59, 30 to 44, and <30mL/min/1.73m(2). In the subgroup of older (≥60 years) individuals, the adjusted mean difference in the EQ-5D index was lower in the CKD eGFR category of 60 to 89mL/min/1.73m(2), but not in the eGFR category of 45 to 59mL/min/1.73m(2), compared to non-CKD.

LIMITATIONS

The survey was conducted on noninstitutionalized civilians, and the chronicity of kidney disease was not verified. Caution is required if our results are applied to special settings and specific populations.

CONCLUSIONS

There was a graded but complex association between CKD and poor health-related quality of life in this large community-based population.

Authors+Show Affiliations

Division of Nephrology, Department of Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Gangwon-do, South Korea.Division of Nephrology, Department of Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Gangwon-do, South Korea.Division of Nephrology, Department of Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Gangwon-do, South Korea. Electronic address: haehyuk@kangwon.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26706255

Citation

Park, Ji In, et al. "CKD and Health-Related Quality of Life: the Korea National Health and Nutrition Examination Survey." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 67, no. 6, 2016, pp. 851-60.
Park JI, Baek H, Jung HH. CKD and Health-Related Quality of Life: The Korea National Health and Nutrition Examination Survey. Am J Kidney Dis. 2016;67(6):851-60.
Park, J. I., Baek, H., & Jung, H. H. (2016). CKD and Health-Related Quality of Life: The Korea National Health and Nutrition Examination Survey. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 67(6), 851-60. https://doi.org/10.1053/j.ajkd.2015.11.005
Park JI, Baek H, Jung HH. CKD and Health-Related Quality of Life: the Korea National Health and Nutrition Examination Survey. Am J Kidney Dis. 2016;67(6):851-60. PubMed PMID: 26706255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CKD and Health-Related Quality of Life: The Korea National Health and Nutrition Examination Survey. AU - Park,Ji In, AU - Baek,Hyunjeong, AU - Jung,Hae Hyuk, Y1 - 2015/12/23/ PY - 2015/04/23/received PY - 2015/11/05/accepted PY - 2015/12/27/entrez PY - 2015/12/27/pubmed PY - 2017/6/1/medline KW - Health-related quality of life (HRQoL) KW - Korea KW - chronic KW - chronic kidney disease (CKD) KW - estimated glomerular filtration rate (eGFR) KW - health status KW - health surveys KW - kidney failure KW - proteinuria KW - renal function SP - 851 EP - 60 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 67 IS - 6 N2 - BACKGROUND: Quality of life is increasingly viewed as an important health outcome. However, the association of chronic kidney disease (CKD) and its severity with health-related quality of life is uncertain. STUDY DESIGN: Nationwide population-based cross-sectional study. SETTING & PARTICIPANTS: 46,676 adults participating in the Korea National Health and Nutrition Examination Survey (KNHANES) 2005 to 2013. PREDICTOR: CKD ascertained as dipstick-positive proteinuria or estimated glomerular filtration rate (eGFR)<60mL/min/1.73m(2). 5 eGFR categories of CKD were compared: ≥90 (with proteinuria), 60 to 89 (with proteinuria), 45 to 59, 30 to 44, and <30mL/min/1.73m(2). OUTCOMES: The EQ-5D index for health status (range, 0 [death] to 1 [optimal health]). RESULTS: The total crude CKD prevalence estimate for adults 20 years or older in Korea was 5.5%. After adjustments for age, sex, risk factors, and comorbid conditions, the EQ-5D index was lower in those with versus without CKD, with mean differences of -0.004 (95% CI, -0.015 to 0.007), -0.016 (95% CI, -0.032 to -0.000), -0.020 (95% CI, -0.029 to -0.011), -0.052 (95% CI, -0.072 to -0.032), and -0.067 (95% CI, -0.101 to -0.032), respectively, for CKD eGFR categories of ≥90, 60 to 89, 45 to 59, 30 to 44, and <30mL/min/1.73m(2). In the subgroup of older (≥60 years) individuals, the adjusted mean difference in the EQ-5D index was lower in the CKD eGFR category of 60 to 89mL/min/1.73m(2), but not in the eGFR category of 45 to 59mL/min/1.73m(2), compared to non-CKD. LIMITATIONS: The survey was conducted on noninstitutionalized civilians, and the chronicity of kidney disease was not verified. Caution is required if our results are applied to special settings and specific populations. CONCLUSIONS: There was a graded but complex association between CKD and poor health-related quality of life in this large community-based population. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/26706255/CKD_and_Health_Related_Quality_of_Life:_The_Korea_National_Health_and_Nutrition_Examination_Survey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(15)01399-2 DB - PRIME DP - Unbound Medicine ER -