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Particle-based simulations of red blood cells-A review.
J Biomech 2016; 49(11):2255-2266JB

Abstract

Particle-based methods have been increasingly attractive for solving biofluid flow problems, because of the ease and flexibility in modeling complex structure fluids afforded by the methods. In this review, we focus on popular particle-based methods widely used in red blood cell (RBC) simulations, including dissipative particle dynamics (DPD), smoothed particle hydrodynamics (SPH), and lattice Boltzmann method (LBM). We introduce their basic ideas and formulations, and present their applications in RBC simulations which are divided into three classes according to the number of RBCs in the simulation: a single RBC, two or multiple RBCs, and RBC suspension. Furthermore, we analyze their advantages and disadvantages. On weighing the pros and cons of the methods, a combination of the immersed boundary (IB) method and some forms of smoothed dissipative particle hydrodynamics (SDPD) methods may be required to deal effectively with RBC simulations.

Authors+Show Affiliations

Department of Computational Mathematics, Jilin University, China.Department of Mechanical Engineering, National University of Singapore, Singapore. Electronic address: nhan@nus.edu.sg.Department of Mechanical Engineering, National University of Singapore, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore. Electronic address: ctlim@nus.edu.sg.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26706718

Citation

Ye, Ting, et al. "Particle-based Simulations of Red Blood cells-A Review." Journal of Biomechanics, vol. 49, no. 11, 2016, pp. 2255-2266.
Ye T, Phan-Thien N, Lim CT. Particle-based simulations of red blood cells-A review. J Biomech. 2016;49(11):2255-2266.
Ye, T., Phan-Thien, N., & Lim, C. T. (2016). Particle-based simulations of red blood cells-A review. Journal of Biomechanics, 49(11), pp. 2255-2266. doi:10.1016/j.jbiomech.2015.11.050.
Ye T, Phan-Thien N, Lim CT. Particle-based Simulations of Red Blood cells-A Review. J Biomech. 2016 07 26;49(11):2255-2266. PubMed PMID: 26706718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Particle-based simulations of red blood cells-A review. AU - Ye,Ting, AU - Phan-Thien,Nhan, AU - Lim,Chwee Teck, Y1 - 2015/12/11/ PY - 2015/11/05/received PY - 2015/11/07/accepted PY - 2015/12/27/entrez PY - 2015/12/27/pubmed PY - 2017/9/8/medline KW - Dissipative particle dynamics KW - Lattice Boltzmann method KW - RBC dynamics KW - RBC rheology KW - Smoothed particle hydrodynamics SP - 2255 EP - 2266 JF - Journal of biomechanics JO - J Biomech VL - 49 IS - 11 N2 - Particle-based methods have been increasingly attractive for solving biofluid flow problems, because of the ease and flexibility in modeling complex structure fluids afforded by the methods. In this review, we focus on popular particle-based methods widely used in red blood cell (RBC) simulations, including dissipative particle dynamics (DPD), smoothed particle hydrodynamics (SPH), and lattice Boltzmann method (LBM). We introduce their basic ideas and formulations, and present their applications in RBC simulations which are divided into three classes according to the number of RBCs in the simulation: a single RBC, two or multiple RBCs, and RBC suspension. Furthermore, we analyze their advantages and disadvantages. On weighing the pros and cons of the methods, a combination of the immersed boundary (IB) method and some forms of smoothed dissipative particle hydrodynamics (SDPD) methods may be required to deal effectively with RBC simulations. SN - 1873-2380 UR - https://www.unboundmedicine.com/medline/citation/26706718/Particle_based_simulations_of_red_blood_cells_A_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9290(15)00692-2 DB - PRIME DP - Unbound Medicine ER -