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Electrospun curcumin loaded poly(ε-caprolactone)/gum tragacanth nanofibers for biomedical application.
Int J Biol Macromol 2016; 84:448-56IJ

Abstract

In this work curcumin (Cur)-loaded poly(ε-caprolactone) (PCL)/gum tragacanth (GT) scaffold membranes which provided the controlled release of curcumin for over 20 days were fabricated by electrospinning. Field Emission Scanning Electron Microscopy (FESEM) analysis, Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) were applied to characterize the produced nanofibers. These nanofibers were evaluated for water absorption capacity, in vitro drug release, biodegradation test, cell culture and MTT analysis. The water contact angle measurements indicated that addition of GT and curcumin in composition resulted in increase in the hydrophilicity of the nanofibers. Biodegradation test for the fabricated nanofibers exhibited that PCL/GT, PCL/Cur-3% and PCL/GT/Cur-3% nanofibers preserved their structure after 15 days. The in vitro release profile of curcumin showed 6.86, 14 and 30.09% burst release for PCL/GT/Cur-1%, PCL/GT/Cur-3% and PCL/Cur-3% nanofibers respectively. The effect of curcumin concentration in the nanofibers composition on the cell viability was assessed by the MTS assay. The cytotoxic effect of released curcumin on the fibroblast cells was examined. The PCL/GT/Cur-3% with suitable mechanical properties, excellent biological characteristics, and maintaining their original structure in degradation media may have potential application as a wound dressing patch for healing slow rate wounds.

Authors+Show Affiliations

Textile Engineering Group, Department of Engineering, University of Bonab, Bonab, Iran. Electronic address: ranjbar.m@aut.ac.ir.Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran. Electronic address: hajirb@aut.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26706845

Citation

Ranjbar-Mohammadi, Marziyeh, and S Hajir Bahrami. "Electrospun Curcumin Loaded Poly(ε-caprolactone)/gum Tragacanth Nanofibers for Biomedical Application." International Journal of Biological Macromolecules, vol. 84, 2016, pp. 448-56.
Ranjbar-Mohammadi M, Bahrami SH. Electrospun curcumin loaded poly(ε-caprolactone)/gum tragacanth nanofibers for biomedical application. Int J Biol Macromol. 2016;84:448-56.
Ranjbar-Mohammadi, M., & Bahrami, S. H. (2016). Electrospun curcumin loaded poly(ε-caprolactone)/gum tragacanth nanofibers for biomedical application. International Journal of Biological Macromolecules, 84, pp. 448-56. doi:10.1016/j.ijbiomac.2015.12.024.
Ranjbar-Mohammadi M, Bahrami SH. Electrospun Curcumin Loaded Poly(ε-caprolactone)/gum Tragacanth Nanofibers for Biomedical Application. Int J Biol Macromol. 2016;84:448-56. PubMed PMID: 26706845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrospun curcumin loaded poly(ε-caprolactone)/gum tragacanth nanofibers for biomedical application. AU - Ranjbar-Mohammadi,Marziyeh, AU - Bahrami,S Hajir, Y1 - 2015/12/17/ PY - 2015/10/22/received PY - 2015/11/18/revised PY - 2015/12/11/accepted PY - 2015/12/27/entrez PY - 2015/12/27/pubmed PY - 2016/10/21/medline KW - Curcumin KW - Gum tragacanth KW - Nanofiber KW - Poly(ε-caprolactone) KW - Scaffolds SP - 448 EP - 56 JF - International journal of biological macromolecules JO - Int. J. Biol. Macromol. VL - 84 N2 - In this work curcumin (Cur)-loaded poly(ε-caprolactone) (PCL)/gum tragacanth (GT) scaffold membranes which provided the controlled release of curcumin for over 20 days were fabricated by electrospinning. Field Emission Scanning Electron Microscopy (FESEM) analysis, Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) were applied to characterize the produced nanofibers. These nanofibers were evaluated for water absorption capacity, in vitro drug release, biodegradation test, cell culture and MTT analysis. The water contact angle measurements indicated that addition of GT and curcumin in composition resulted in increase in the hydrophilicity of the nanofibers. Biodegradation test for the fabricated nanofibers exhibited that PCL/GT, PCL/Cur-3% and PCL/GT/Cur-3% nanofibers preserved their structure after 15 days. The in vitro release profile of curcumin showed 6.86, 14 and 30.09% burst release for PCL/GT/Cur-1%, PCL/GT/Cur-3% and PCL/Cur-3% nanofibers respectively. The effect of curcumin concentration in the nanofibers composition on the cell viability was assessed by the MTS assay. The cytotoxic effect of released curcumin on the fibroblast cells was examined. The PCL/GT/Cur-3% with suitable mechanical properties, excellent biological characteristics, and maintaining their original structure in degradation media may have potential application as a wound dressing patch for healing slow rate wounds. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/26706845/Electrospun_curcumin_loaded_poly_ε_caprolactone_/gum_tragacanth_nanofibers_for_biomedical_application_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(15)30220-8 DB - PRIME DP - Unbound Medicine ER -