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Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk gene neuregulin 1.
Genes Brain Behav. 2016 Mar; 15(3):295-304.GB

Abstract

Schizophrenia patients are often obese or overweight and poor dietary choices appear to be a factor in this phenomenon. Poor diet has been found to have complex consequences for the mental state of patients. Thus, this study investigated whether an unhealthy diet [i.e. high fat diet (HFD)] impacts on the behaviour of a genetic mouse model for the schizophrenia risk gene neuregulin 1 (i.e. transmembrane domain Nrg1 mutant mice: Nrg1 HET). Female Nrg1 HET and wild-type-like littermates (WT) were fed with either HFD or a control chow diet. The mice were tested for baseline (e.g. anxiety) and schizophrenia-relevant behaviours after 7 weeks of diet exposure. HFD increased body weight and impaired glucose tolerance in all mice. Only Nrg1 females on HFD displayed a hyper-locomotive phenotype as locomotion-suppressive effects of HFD were only evident in WT mice. HFD also induced an anxiety-like response and increased freezing in the context and the cued version of the fear conditioning task. Importantly, CHOW-fed Nrg1 females displayed impaired social recognition memory, which was absent in HFD-fed mutants. Sensorimotor gating deficits of Nrg1 females were not affected by diet. In summary, HFD had complex effects on the behavioural phenotype of test mice and attenuated particular cognitive deficits of Nrg1 mutant females. This topic requires further investigations thereby also considering other dietary factors of relevance for schizophrenia as well as interactive effects of diet with medication and sex.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Holm-Hansen S
Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, University of Oslo, Oslo, Norway.
Low JK
Neuroscience Research Australia, Sydney, Australia. Schizophrenia Research Institute, Randwick, Australia.
Zieba J
Neuroscience Research Australia, Sydney, Australia. Schizophrenia Research Institute, Randwick, Australia.
Gjedde A
Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Bergersen LH
Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, University of Oslo, Oslo, Norway. Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Karl T
Neuroscience Research Australia, Sydney, Australia. Schizophrenia Research Institute, Randwick, Australia. School of Medical Sciences, University of New South Wales, Sydney, Australia.

MeSH

AnimalsBehavior, AnimalBody WeightDiet, High-FatDisease Models, AnimalExploratory BehaviorFemaleLocomotionMiceMice, Inbred StrainsMotor ActivityNeuregulin-1Reflex, StartleRisk FactorsSchizophreniaSensory Gating

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26707035

Citation

Holm-Hansen, S, et al. "Behavioural Effects of High Fat Diet in a Mutant Mouse Model for the Schizophrenia Risk Gene Neuregulin 1." Genes, Brain, and Behavior, vol. 15, no. 3, 2016, pp. 295-304.
Holm-Hansen S, Low JK, Zieba J, et al. Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk gene neuregulin 1. Genes Brain Behav. 2016;15(3):295-304.
Holm-Hansen, S., Low, J. K., Zieba, J., Gjedde, A., Bergersen, L. H., & Karl, T. (2016). Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk gene neuregulin 1. Genes, Brain, and Behavior, 15(3), 295-304. https://doi.org/10.1111/gbb.12267
Holm-Hansen S, et al. Behavioural Effects of High Fat Diet in a Mutant Mouse Model for the Schizophrenia Risk Gene Neuregulin 1. Genes Brain Behav. 2016;15(3):295-304. PubMed PMID: 26707035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk gene neuregulin 1. AU - Holm-Hansen,S, AU - Low,J K, AU - Zieba,J, AU - Gjedde,A, AU - Bergersen,L H, AU - Karl,T, Y1 - 2016/02/17/ PY - 2015/05/25/received PY - 2015/07/29/revised PY - 2015/07/29/accepted PY - 2015/12/29/entrez PY - 2015/12/29/pubmed PY - 2016/11/15/medline KW - Anxiety KW - behaviour KW - cognition KW - fear-associated memory KW - gene-environment interaction KW - glucose tolerance KW - high fat diet KW - hyperlocomotion KW - mouse model KW - neuregulin 1 KW - schizophrenia KW - sensorimotor gating KW - social preference SP - 295 EP - 304 JF - Genes, brain, and behavior JO - Genes Brain Behav VL - 15 IS - 3 N2 - Schizophrenia patients are often obese or overweight and poor dietary choices appear to be a factor in this phenomenon. Poor diet has been found to have complex consequences for the mental state of patients. Thus, this study investigated whether an unhealthy diet [i.e. high fat diet (HFD)] impacts on the behaviour of a genetic mouse model for the schizophrenia risk gene neuregulin 1 (i.e. transmembrane domain Nrg1 mutant mice: Nrg1 HET). Female Nrg1 HET and wild-type-like littermates (WT) were fed with either HFD or a control chow diet. The mice were tested for baseline (e.g. anxiety) and schizophrenia-relevant behaviours after 7 weeks of diet exposure. HFD increased body weight and impaired glucose tolerance in all mice. Only Nrg1 females on HFD displayed a hyper-locomotive phenotype as locomotion-suppressive effects of HFD were only evident in WT mice. HFD also induced an anxiety-like response and increased freezing in the context and the cued version of the fear conditioning task. Importantly, CHOW-fed Nrg1 females displayed impaired social recognition memory, which was absent in HFD-fed mutants. Sensorimotor gating deficits of Nrg1 females were not affected by diet. In summary, HFD had complex effects on the behavioural phenotype of test mice and attenuated particular cognitive deficits of Nrg1 mutant females. This topic requires further investigations thereby also considering other dietary factors of relevance for schizophrenia as well as interactive effects of diet with medication and sex. SN - 1601-183X UR - https://www.unboundmedicine.com/medline/citation/26707035/Behavioural_effects_of_high_fat_diet_in_a_mutant_mouse_model_for_the_schizophrenia_risk_gene_neuregulin_1_ DB - PRIME DP - Unbound Medicine ER -