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Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1 Mouse Model.
Neurotox Res. 2016 Feb; 29(2):256-66.NR

Abstract

Alzheimer's disease (AD) is the most common form of dementia among the elderly, characterized by parenchymal and vascular beta-amyloid (Aβ) burden, tau pathology, neuroinflammation, and loss of neurons and synapses. There is a clear sex difference in the prevalence of AD. However, sex differences in AD-type pathologies have not been systematically documented. Applying 12-month-old female and male APP/PS1 mice as a model, we investigated the sex dimorphism in these major pathological indices. Compared with male APP/PS1 mice, the females exhibited higher parenchymal Aβ burdens, with the sex difference in hippocampus being the most significant. Female APP/PS1 mice had more severe cerebral amyloid angiopathy and subsequent microhemorrhage. In addition, female APP/PS1 mice also showed higher levels of phosphorylated tau and proinflammatory cytokines, more severe astrocytosis and microgliosis, and greater neuronal and synaptic degenerations. The present study systematically described a sex dimorphism in AD-type pathologic indices, suggesting that gender should be taken into account in designing studies involving these pathological indices and when interpreting the relevant findings in those studies.

Authors+Show Affiliations

Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China. wayaja@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26707129

Citation

Jiao, Shu-Sheng, et al. "Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1 Mouse Model." Neurotoxicity Research, vol. 29, no. 2, 2016, pp. 256-66.
Jiao SS, Bu XL, Liu YH, et al. Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1 Mouse Model. Neurotox Res. 2016;29(2):256-66.
Jiao, S. S., Bu, X. L., Liu, Y. H., Zhu, C., Wang, Q. H., Shen, L. L., Liu, C. H., Wang, Y. R., Yao, X. Q., & Wang, Y. J. (2016). Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1 Mouse Model. Neurotoxicity Research, 29(2), 256-66. https://doi.org/10.1007/s12640-015-9589-x
Jiao SS, et al. Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1 Mouse Model. Neurotox Res. 2016;29(2):256-66. PubMed PMID: 26707129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1 Mouse Model. AU - Jiao,Shu-Sheng, AU - Bu,Xian-Le, AU - Liu,Yu-Hui, AU - Zhu,Chi, AU - Wang,Qing-Hua, AU - Shen,Lin-Lin, AU - Liu,Cheng-Hui, AU - Wang,Ye-Ran, AU - Yao,Xiu-Qing, AU - Wang,Yan-Jiang, Y1 - 2015/12/26/ PY - 2015/07/09/received PY - 2015/12/10/accepted PY - 2015/10/06/revised PY - 2015/12/29/entrez PY - 2015/12/29/pubmed PY - 2016/10/16/medline KW - Alzheimer’s disease KW - Beta-amyloid KW - Cerebral amyloid angiopathy KW - Loss of neurons and synapses KW - Neuroinflammation KW - Sex dimorphism KW - Tau pathology SP - 256 EP - 66 JF - Neurotoxicity research JO - Neurotox Res VL - 29 IS - 2 N2 - Alzheimer's disease (AD) is the most common form of dementia among the elderly, characterized by parenchymal and vascular beta-amyloid (Aβ) burden, tau pathology, neuroinflammation, and loss of neurons and synapses. There is a clear sex difference in the prevalence of AD. However, sex differences in AD-type pathologies have not been systematically documented. Applying 12-month-old female and male APP/PS1 mice as a model, we investigated the sex dimorphism in these major pathological indices. Compared with male APP/PS1 mice, the females exhibited higher parenchymal Aβ burdens, with the sex difference in hippocampus being the most significant. Female APP/PS1 mice had more severe cerebral amyloid angiopathy and subsequent microhemorrhage. In addition, female APP/PS1 mice also showed higher levels of phosphorylated tau and proinflammatory cytokines, more severe astrocytosis and microgliosis, and greater neuronal and synaptic degenerations. The present study systematically described a sex dimorphism in AD-type pathologic indices, suggesting that gender should be taken into account in designing studies involving these pathological indices and when interpreting the relevant findings in those studies. SN - 1476-3524 UR - https://www.unboundmedicine.com/medline/citation/26707129/Sex_Dimorphism_Profile_of_Alzheimer's_Disease_Type_Pathologies_in_an_APP/PS1_Mouse_Model_ L2 - https://dx.doi.org/10.1007/s12640-015-9589-x DB - PRIME DP - Unbound Medicine ER -