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Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis.
Neuropsychopharmacology 2016; 41(8):1974-82N

Abstract

Cannabidiol (CBD), a constituent of cannabis with few psychoactive effects, has been reported in some studies to attenuate certain aspects of Δ(9)-tetrahydrocannabinol (THC) intoxication. However, most studies have tested only one dose of CBD in combination with one dose of oral THC, making it difficult to assess the nature of this interaction. Further, the effect of oral CBD on smoked cannabis administration is unknown. The objective of this multi-site, randomized, double-blind, within-subject laboratory study was to assess the influence of CBD (0, 200, 400, 800 mg, p.o.) pretreatment on the reinforcing, subjective, cognitive, and physiological effects of smoked cannabis (0.01 (inactive), 5.30-5.80% THC). Non-treatment-seeking, healthy cannabis smokers (n=31; 17M, 14 F) completed eight outpatient sessions. CBD was administered 90 min prior to cannabis administration. The behavioral and cardiovascular effects of cannabis were measured at baseline and repeatedly throughout the session. A subset of participants (n=8) completed an additional session to measure plasma CBD concentrations after administration of the highest CBD dose (800 mg). Under placebo CBD conditions, active cannabis (1) was self-administered by significantly more participants than placebo cannabis and (2) produced significant, time-dependent increases in ratings of 'High', 'Good Effect', ratings of the cannabis cigarette (eg, strength, liking), and heart rate relative to inactive cannabis. CBD, which alone produced no significant psychoactive or cardiovascular effects, did not significantly alter any of these outcomes. Cannabis self-administration, subjective effects, and cannabis ratings did not vary as a function of CBD dose relative to placebo capsules. These findings suggest that oral CBD does not reduce the reinforcing, physiological, or positive subjective effects of smoked cannabis.

Authors+Show Affiliations

Division on Substance Abuse, New York State Psychiatric Institute and the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.Medical University of South Carolina, Charleston, SC, USA.University of Kentucky, Lexington, KY, USA.University of Kentucky, Lexington, KY, USA.Division on Substance Abuse, New York State Psychiatric Institute and the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.Division on Substance Abuse, New York State Psychiatric Institute and the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.Medical University of South Carolina, Charleston, SC, USA.Medical University of South Carolina, Charleston, SC, USA.University of Kentucky, Lexington, KY, USA.National Institute on Drug Abuse, Bethesda, MD, USA.University of Kentucky, Lexington, KY, USA.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26708108

Citation

Haney, Margaret, et al. "Oral Cannabidiol Does Not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 41, no. 8, 2016, pp. 1974-82.
Haney M, Malcolm RJ, Babalonis S, et al. Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis. Neuropsychopharmacology. 2016;41(8):1974-82.
Haney, M., Malcolm, R. J., Babalonis, S., Nuzzo, P. A., Cooper, Z. D., Bedi, G., ... Walsh, S. L. (2016). Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 41(8), pp. 1974-82. doi:10.1038/npp.2015.367.
Haney M, et al. Oral Cannabidiol Does Not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis. Neuropsychopharmacology. 2016;41(8):1974-82. PubMed PMID: 26708108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis. AU - Haney,Margaret, AU - Malcolm,Robert J, AU - Babalonis,Shanna, AU - Nuzzo,Paul A, AU - Cooper,Ziva D, AU - Bedi,Gillinder, AU - Gray,Kevin M, AU - McRae-Clark,Aimee, AU - Lofwall,Michelle R, AU - Sparenborg,Steven, AU - Walsh,Sharon L, Y1 - 2015/12/28/ PY - 2015/10/29/received PY - 2015/12/18/revised PY - 2015/12/21/accepted PY - 2015/12/29/entrez PY - 2015/12/29/pubmed PY - 2018/1/16/medline SP - 1974 EP - 82 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 41 IS - 8 N2 - Cannabidiol (CBD), a constituent of cannabis with few psychoactive effects, has been reported in some studies to attenuate certain aspects of Δ(9)-tetrahydrocannabinol (THC) intoxication. However, most studies have tested only one dose of CBD in combination with one dose of oral THC, making it difficult to assess the nature of this interaction. Further, the effect of oral CBD on smoked cannabis administration is unknown. The objective of this multi-site, randomized, double-blind, within-subject laboratory study was to assess the influence of CBD (0, 200, 400, 800 mg, p.o.) pretreatment on the reinforcing, subjective, cognitive, and physiological effects of smoked cannabis (0.01 (inactive), 5.30-5.80% THC). Non-treatment-seeking, healthy cannabis smokers (n=31; 17M, 14 F) completed eight outpatient sessions. CBD was administered 90 min prior to cannabis administration. The behavioral and cardiovascular effects of cannabis were measured at baseline and repeatedly throughout the session. A subset of participants (n=8) completed an additional session to measure plasma CBD concentrations after administration of the highest CBD dose (800 mg). Under placebo CBD conditions, active cannabis (1) was self-administered by significantly more participants than placebo cannabis and (2) produced significant, time-dependent increases in ratings of 'High', 'Good Effect', ratings of the cannabis cigarette (eg, strength, liking), and heart rate relative to inactive cannabis. CBD, which alone produced no significant psychoactive or cardiovascular effects, did not significantly alter any of these outcomes. Cannabis self-administration, subjective effects, and cannabis ratings did not vary as a function of CBD dose relative to placebo capsules. These findings suggest that oral CBD does not reduce the reinforcing, physiological, or positive subjective effects of smoked cannabis. SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/26708108/Oral_Cannabidiol_does_not_Alter_the_Subjective_Reinforcing_or_Cardiovascular_Effects_of_Smoked_Cannabis_ L2 - http://dx.doi.org/10.1038/npp.2015.367 DB - PRIME DP - Unbound Medicine ER -