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The correlation between intradermal testing and serum specific IgE to house dust mite in negative skin prick test allergic rhinitis adult patients.
Asian Pac J Allergy Immunol. 2015 Dec; 33(4):308-11.AP

Abstract

BACKGROUND

Diagnosis of allergic rhinitis (AR) is based on history, physical examination, and skin prick test (SPT) while intradermal (ID) test can be performed to confirm the diagnosis in case of negative result of SPT. However, the ID test is not recommended for cat and timothy grass allergy because of its high false positive rate. As a result, the "quantitative" technique of serum specific IgE (sIgE) measurement might be helpful to diagnose AR with more confidence.

OBJECTIVES

To evaluate the correlation between ID tests and sIgE in the diagnosis of house dust mite (HDM)-sensitive AR patients.

METHODS

Patients with chronic rhinitis (CR) were recruited and SPT was performed. If SPT was negative, ID test and sIgE to HDM [Dermatophagoides pteronyssinus (Dp)] measurement were performed.

RESULTS

Eighty-two patients with chronic rhinitis (CR), whose SPTs were negative for Dp, were included. There were 39 males (47.6%) and 43 females (52.4%) aged between 18 and 76 years old (mean age = 43.3 years). The ID test was positive in 13 patients (15.9%), and was negative in 69 patients (84.1 %). sIgE to HDM was positive (≥ 0.35 kUA/l) in 2 patients (2.4%). There was a fair to moderate correlation between the size of wheal of ID test and sIgE to HDM (r = 0.44, 95% confidence interval: 0.19 to 0.67, p < 0.01).

CONCLUSION

ID test has a fair to moderate correlation with sIgE Dermatophagoides pteronyssinus and it can be used in CR patients with negative SPT where sIgE is not feasible.

Authors+Show Affiliations

Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26708395

Citation

Tantilipikorn, Pongsakorn, et al. "The Correlation Between Intradermal Testing and Serum Specific IgE to House Dust Mite in Negative Skin Prick Test Allergic Rhinitis Adult Patients." Asian Pacific Journal of Allergy and Immunology, vol. 33, no. 4, 2015, pp. 308-11.
Tantilipikorn P, Danpornprasert P, Ngaotepprutaram P, et al. The correlation between intradermal testing and serum specific IgE to house dust mite in negative skin prick test allergic rhinitis adult patients. Asian Pac J Allergy Immunol. 2015;33(4):308-11.
Tantilipikorn, P., Danpornprasert, P., Ngaotepprutaram, P., Assanasen, P., Bunnag, C., & Thinkhamrop, B. (2015). The correlation between intradermal testing and serum specific IgE to house dust mite in negative skin prick test allergic rhinitis adult patients. Asian Pacific Journal of Allergy and Immunology, 33(4), 308-11. https://doi.org/10.12932/AP0579.33.4.2015
Tantilipikorn P, et al. The Correlation Between Intradermal Testing and Serum Specific IgE to House Dust Mite in Negative Skin Prick Test Allergic Rhinitis Adult Patients. Asian Pac J Allergy Immunol. 2015;33(4):308-11. PubMed PMID: 26708395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The correlation between intradermal testing and serum specific IgE to house dust mite in negative skin prick test allergic rhinitis adult patients. AU - Tantilipikorn,Pongsakorn, AU - Danpornprasert,Piyanart, AU - Ngaotepprutaram,Premyot, AU - Assanasen,Paraya, AU - Bunnag,Chaweewan, AU - Thinkhamrop,Bandit, PY - 2014/10/20/received PY - 2015/05/07/accepted PY - 2015/12/29/entrez PY - 2015/12/29/pubmed PY - 2016/3/15/medline SP - 308 EP - 11 JF - Asian Pacific journal of allergy and immunology JO - Asian Pac. J. Allergy Immunol. VL - 33 IS - 4 N2 - BACKGROUND: Diagnosis of allergic rhinitis (AR) is based on history, physical examination, and skin prick test (SPT) while intradermal (ID) test can be performed to confirm the diagnosis in case of negative result of SPT. However, the ID test is not recommended for cat and timothy grass allergy because of its high false positive rate. As a result, the "quantitative" technique of serum specific IgE (sIgE) measurement might be helpful to diagnose AR with more confidence. OBJECTIVES: To evaluate the correlation between ID tests and sIgE in the diagnosis of house dust mite (HDM)-sensitive AR patients. METHODS: Patients with chronic rhinitis (CR) were recruited and SPT was performed. If SPT was negative, ID test and sIgE to HDM [Dermatophagoides pteronyssinus (Dp)] measurement were performed. RESULTS: Eighty-two patients with chronic rhinitis (CR), whose SPTs were negative for Dp, were included. There were 39 males (47.6%) and 43 females (52.4%) aged between 18 and 76 years old (mean age = 43.3 years). The ID test was positive in 13 patients (15.9%), and was negative in 69 patients (84.1 %). sIgE to HDM was positive (≥ 0.35 kUA/l) in 2 patients (2.4%). There was a fair to moderate correlation between the size of wheal of ID test and sIgE to HDM (r = 0.44, 95% confidence interval: 0.19 to 0.67, p < 0.01). CONCLUSION: ID test has a fair to moderate correlation with sIgE Dermatophagoides pteronyssinus and it can be used in CR patients with negative SPT where sIgE is not feasible. SN - 0125-877X UR - https://www.unboundmedicine.com/medline/citation/26708395/The_correlation_between_intradermal_testing_and_serum_specific_IgE_to_house_dust_mite_in_negative_skin_prick_test_allergic_rhinitis_adult_patients_ L2 - http://apjai-journal.org/wp-content/uploads/2016/10/8ThecorrelationAPJAIVol33No4December2015P308.pdf DB - PRIME DP - Unbound Medicine ER -