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Effects of Single and Multiple Energy Shots on Blood Pressure and Electrocardiographic Parameters.
Am J Cardiol. 2016 Feb 01; 117(3):465-8.AJ

Abstract

We assessed the effects of single and multiple caffeinated energy shots on hemodynamic and electrocardiographic (ECG) parameters. This was a randomized, double-blinded, placebo-controlled, crossover study in otherwise healthy volunteers (n = 26) where a caffeinated energy shot or matching placebo was ingested. The study drink was consumed twice daily for 7 days during each phase, with a 7-day washout period in between. The primary end points of interest were systolic and diastolic blood pressure (BP), heart rate, PR interval, QRS duration, and QT and QTc intervals. All parameters were evaluated at baseline, 1, 3, and 5 hours on the first and seventh day of each phase. Systolic BP after a single energy shot consumption was significantly higher than placebo at 3 and 5 hours (p = 0.050 and p = 0.038, respectively). Similarly, diastolic BP after a single energy shot consumption was significantly higher at 1 and 5 hours (p = 0.019 and p = 0.043, respectively). The systolic and diastolic BP elevations were not significant after consistent consumption (all p values ≥ 0.079). None of the ECG parameters were significantly affected (all p values ≥ 0.108) compared with placebo. In conclusion, a single shot of a caffeinated energy drink significantly raised systolic and diastolic BPs. However, these elevations were not sustained with chronic consumption. ECG parameters were not altered.

Authors+Show Affiliations

Department of Pharmacy, David Grant Medical Center, Pharmacy Research Department, Travis Air Force Base, Travis AFB, California; Department of Pharmacy Practice, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California. Electronic address: sshah@pacific.edu.Department of Pharmacy, David Grant Medical Center, Pharmacy Research Department, Travis Air Force Base, Travis AFB, California.Clinical Investigation Facility, David Grant Medical Center, Pharmacy Research Department, Travis Air Force Base, Travis AFB, California.Department of Pharmacy, David Grant Medical Center, Pharmacy Research Department, Travis Air Force Base, Travis AFB, California.Clinical Investigation Facility, David Grant Medical Center, Pharmacy Research Department, Travis Air Force Base, Travis AFB, California.Clinical Investigation Facility, David Grant Medical Center, Pharmacy Research Department, Travis Air Force Base, Travis AFB, California.Department of Cardiology, David Grant Medical Center, Pharmacy Research Department, Travis Air Force Base, Travis AFB, California.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26708636

Citation

Shah, Sachin A., et al. "Effects of Single and Multiple Energy Shots On Blood Pressure and Electrocardiographic Parameters." The American Journal of Cardiology, vol. 117, no. 3, 2016, pp. 465-8.
Shah SA, Dargush AE, Potts V, et al. Effects of Single and Multiple Energy Shots on Blood Pressure and Electrocardiographic Parameters. Am J Cardiol. 2016;117(3):465-8.
Shah, S. A., Dargush, A. E., Potts, V., Lee, M., Millard-Hasting, B. M., Williams, B., & Lacey, C. S. (2016). Effects of Single and Multiple Energy Shots on Blood Pressure and Electrocardiographic Parameters. The American Journal of Cardiology, 117(3), 465-8. https://doi.org/10.1016/j.amjcard.2015.11.017
Shah SA, et al. Effects of Single and Multiple Energy Shots On Blood Pressure and Electrocardiographic Parameters. Am J Cardiol. 2016 Feb 1;117(3):465-8. PubMed PMID: 26708636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Single and Multiple Energy Shots on Blood Pressure and Electrocardiographic Parameters. AU - Shah,Sachin A, AU - Dargush,Anthony E, AU - Potts,Vicki, AU - Lee,Michael, AU - Millard-Hasting,Brittany M, AU - Williams,Bradley, AU - Lacey,Carolyn S, Y1 - 2015/11/19/ PY - 2015/09/03/received PY - 2015/11/09/revised PY - 2015/11/09/accepted PY - 2015/12/29/entrez PY - 2015/12/29/pubmed PY - 2016/5/20/medline SP - 465 EP - 8 JF - The American journal of cardiology JO - Am J Cardiol VL - 117 IS - 3 N2 - We assessed the effects of single and multiple caffeinated energy shots on hemodynamic and electrocardiographic (ECG) parameters. This was a randomized, double-blinded, placebo-controlled, crossover study in otherwise healthy volunteers (n = 26) where a caffeinated energy shot or matching placebo was ingested. The study drink was consumed twice daily for 7 days during each phase, with a 7-day washout period in between. The primary end points of interest were systolic and diastolic blood pressure (BP), heart rate, PR interval, QRS duration, and QT and QTc intervals. All parameters were evaluated at baseline, 1, 3, and 5 hours on the first and seventh day of each phase. Systolic BP after a single energy shot consumption was significantly higher than placebo at 3 and 5 hours (p = 0.050 and p = 0.038, respectively). Similarly, diastolic BP after a single energy shot consumption was significantly higher at 1 and 5 hours (p = 0.019 and p = 0.043, respectively). The systolic and diastolic BP elevations were not significant after consistent consumption (all p values ≥ 0.079). None of the ECG parameters were significantly affected (all p values ≥ 0.108) compared with placebo. In conclusion, a single shot of a caffeinated energy drink significantly raised systolic and diastolic BPs. However, these elevations were not sustained with chronic consumption. ECG parameters were not altered. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/26708636/Effects_of_Single_and_Multiple_Energy_Shots_on_Blood_Pressure_and_Electrocardiographic_Parameters_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(15)02256-0 DB - PRIME DP - Unbound Medicine ER -