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Fatigue in early axial spondyloarthritis. Results from the French DESIR cohort.
Joint Bone Spine. 2016 Jul; 83(4):427-31.JB

Abstract

INTRODUCTION

Fatigue is frequent in long-standing axial spondyloarthritis (axSpA); its frequency in early axSpA and its causes are unclear. The objective was to evaluate the magnitude of fatigue in early axSpA and to assess if fatigue appeared more strongly associated with patient- or with disease-related characteristics.

METHODS

Patients were assessed in DESIR, a national observational cohort of patients with recent (<3 years duration) inflammatory back pain suggestive of axSpA. Magnitude of fatigue was assessed by a numeric rating scale (0-10) over one year. Factors associated with high fatigue (≥5/10) at 12 months were assessed by univariate and multivariate logistic regression, for patients fulfilling the ASAS axSpA criteria.

RESULTS

Of the 708 patients, 486 fulfilled the ASAS criteria for axSpA: mean age 33±9 years; 244 (50%) males. Magnitude of fatigue was high at baseline (mean fatigue: 5.7±2.3) and decreased only slightly over the first year, and was overlapping in patients fulfilling the ASAS criteria or not. High fatigue at 12 months was well explained (variance explained: 0.84) by a higher ASDAS-CRP (odds ratio [OR]: 3.05 [95% confidence interval (CI) 2.27-4.12], P<0.0001), higher Bath Anylosing Spondylitis Patient Global (BAS-G) (OR: 3.51 [95% CI, 2.08-6.02], P<0.0001) and with borderline significance, female gender (OR: 1.65 [95% CI, 1.00-2.71], P=0.049).

CONCLUSION

Fatigue levels were high in this population, both for patients fulfilling or not, the ASAS criteria for axSpA. High fatigue was closely related to disease-related variables, indicating fatigue may be an integral part of the disease process in axSpA.

Authors+Show Affiliations

Institut Pierre-Louis d'épidémiologie et de santé publique, GRC-UPMC 08 (EEMOIS), Sorbonne Universités, UPMC Université Paris 06, 75013 Paris, France; Department of rheumatology, Pitié-Salpêtrière hospital, AP-HP, 75013 Paris, France. Electronic address: laure.gossec@aphp.fr.Paris Descartes University, Rheumatology Department, Cochin Hospital, AP-HP, 75014 Paris, France; Inserm (U1153), Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, 75013 Paris, France.Simone-Veil faculty of medicine, University of Versailles-Saint-Quentin-en-Yvelines, 78000 Versailles, France; Inserm U1173, laboratoire d'excellence INFLAMEX, 78180 Montigny-le-Bretonneux, France; Rheumatology Department, Ambroise-Paré Hospital, Assistance Publique-Hôpitaux de Paris, 92100 Boulogne-Billancourt, France.Institut Pierre-Louis d'épidémiologie et de santé publique, GRC-UPMC 08 (EEMOIS), Sorbonne Universités, UPMC Université Paris 06, 75013 Paris, France; Department of rheumatology, Pitié-Salpêtrière hospital, AP-HP, 75013 Paris, France.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Observational Study

Language

eng

PubMed ID

26709252

Citation

Gossec, Laure, et al. "Fatigue in Early Axial Spondyloarthritis. Results From the French DESIR Cohort." Joint, Bone, Spine : Revue Du Rhumatisme, vol. 83, no. 4, 2016, pp. 427-31.
Gossec L, Dougados M, D'Agostino MA, et al. Fatigue in early axial spondyloarthritis. Results from the French DESIR cohort. Joint Bone Spine. 2016;83(4):427-31.
Gossec, L., Dougados, M., D'Agostino, M. A., & Fautrel, B. (2016). Fatigue in early axial spondyloarthritis. Results from the French DESIR cohort. Joint, Bone, Spine : Revue Du Rhumatisme, 83(4), 427-31. https://doi.org/10.1016/j.jbspin.2015.07.012
Gossec L, et al. Fatigue in Early Axial Spondyloarthritis. Results From the French DESIR Cohort. Joint Bone Spine. 2016;83(4):427-31. PubMed PMID: 26709252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatigue in early axial spondyloarthritis. Results from the French DESIR cohort. AU - Gossec,Laure, AU - Dougados,Maxime, AU - D'Agostino,Maria-Antonietta, AU - Fautrel,Bruno, Y1 - 2015/12/18/ PY - 2015/04/14/received PY - 2015/07/25/accepted PY - 2015/12/29/entrez PY - 2015/12/29/pubmed PY - 2017/9/14/medline KW - BASDAI KW - Fatigue KW - Quality of life KW - Spondyloarthritis/ankylosing spondylitis SP - 427 EP - 31 JF - Joint, bone, spine : revue du rhumatisme JO - Joint Bone Spine VL - 83 IS - 4 N2 - INTRODUCTION: Fatigue is frequent in long-standing axial spondyloarthritis (axSpA); its frequency in early axSpA and its causes are unclear. The objective was to evaluate the magnitude of fatigue in early axSpA and to assess if fatigue appeared more strongly associated with patient- or with disease-related characteristics. METHODS: Patients were assessed in DESIR, a national observational cohort of patients with recent (<3 years duration) inflammatory back pain suggestive of axSpA. Magnitude of fatigue was assessed by a numeric rating scale (0-10) over one year. Factors associated with high fatigue (≥5/10) at 12 months were assessed by univariate and multivariate logistic regression, for patients fulfilling the ASAS axSpA criteria. RESULTS: Of the 708 patients, 486 fulfilled the ASAS criteria for axSpA: mean age 33±9 years; 244 (50%) males. Magnitude of fatigue was high at baseline (mean fatigue: 5.7±2.3) and decreased only slightly over the first year, and was overlapping in patients fulfilling the ASAS criteria or not. High fatigue at 12 months was well explained (variance explained: 0.84) by a higher ASDAS-CRP (odds ratio [OR]: 3.05 [95% confidence interval (CI) 2.27-4.12], P<0.0001), higher Bath Anylosing Spondylitis Patient Global (BAS-G) (OR: 3.51 [95% CI, 2.08-6.02], P<0.0001) and with borderline significance, female gender (OR: 1.65 [95% CI, 1.00-2.71], P=0.049). CONCLUSION: Fatigue levels were high in this population, both for patients fulfilling or not, the ASAS criteria for axSpA. High fatigue was closely related to disease-related variables, indicating fatigue may be an integral part of the disease process in axSpA. SN - 1778-7254 UR - https://www.unboundmedicine.com/medline/citation/26709252/Fatigue_in_early_axial_spondyloarthritis__Results_from_the_French_DESIR_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1297-319X(15)00289-4 DB - PRIME DP - Unbound Medicine ER -