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Coffee consumption and the risk of incident gastric cancer--A meta-analysis of prospective cohort studies.
Nutr Cancer. 2016; 68(1):40-7.NC

Abstract

As several epidemiological studies on the association of coffee consumption with gastric cancer risk have produced inconsistent results, this meta-analysis was designed to synthesize current evidence of this potential relationship. We searched PubMed, EMBASE, and the Cochrane Library up to September 2014 to retrieve relevant articles. Prospective cohort studies were included if the relative risks (RRs) or hazard ratios and 95% confidence intervals (CIs) for gastric cancer according to coffee consumption were reported. Fixed- or random-effects models were used based on heterogeneity. The search yielded 13 eligible cohort studies of 3484 incident gastric cancer patients from among 1,324,559 participants. A significantly increased risk was found between gastric cardia cancer and coffee consumption (RR = 1.50, 95% CI: 1.09-2.07). Compared with Europeans (RR = 1.12, 95% CI: 0.86-1.46) and Asians (RR = 0.96, 95% CI: 0.72-1.27), Americans (RR = 1.36, 95% CI: 1.06-1.74) demonstrated a significantly positive association. However, the significant differences of the pooled results vanished after adjusting for smoking or body mass index. Our meta-analysis results suggest that a high level of coffee consumption is a risk factor for gastric cancer. However, these results should not be overinterpreted because residual confounding effects of other factors could exist.

Authors+Show Affiliations

a Department of General Surgery , Beijing Friendship Hospital, Capital Medical University , Beijing , China.b Department of General Surgery , Beijing Hospital , Dongdan , Beijing , China.a Department of General Surgery , Beijing Friendship Hospital, Capital Medical University , Beijing , China.a Department of General Surgery , Beijing Friendship Hospital, Capital Medical University , Beijing , China.a Department of General Surgery , Beijing Friendship Hospital, Capital Medical University , Beijing , China.a Department of General Surgery , Beijing Friendship Hospital, Capital Medical University , Beijing , China.a Department of General Surgery , Beijing Friendship Hospital, Capital Medical University , Beijing , China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

26710312

Citation

Deng, Wei, et al. "Coffee Consumption and the Risk of Incident Gastric cancer--A Meta-analysis of Prospective Cohort Studies." Nutrition and Cancer, vol. 68, no. 1, 2016, pp. 40-7.
Deng W, Yang H, Wang J, et al. Coffee consumption and the risk of incident gastric cancer--A meta-analysis of prospective cohort studies. Nutr Cancer. 2016;68(1):40-7.
Deng, W., Yang, H., Wang, J., Cai, J., Bai, Z., Song, J., & Zhang, Z. (2016). Coffee consumption and the risk of incident gastric cancer--A meta-analysis of prospective cohort studies. Nutrition and Cancer, 68(1), 40-7. https://doi.org/10.1080/01635581.2016.1115093
Deng W, et al. Coffee Consumption and the Risk of Incident Gastric cancer--A Meta-analysis of Prospective Cohort Studies. Nutr Cancer. 2016;68(1):40-7. PubMed PMID: 26710312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and the risk of incident gastric cancer--A meta-analysis of prospective cohort studies. AU - Deng,Wei, AU - Yang,Hua, AU - Wang,Jin, AU - Cai,Jun, AU - Bai,Zhigang, AU - Song,Jianning, AU - Zhang,Zhongtao, Y1 - 2015/12/28/ PY - 2015/12/29/entrez PY - 2015/12/29/pubmed PY - 2016/12/15/medline SP - 40 EP - 7 JF - Nutrition and cancer JO - Nutr Cancer VL - 68 IS - 1 N2 - As several epidemiological studies on the association of coffee consumption with gastric cancer risk have produced inconsistent results, this meta-analysis was designed to synthesize current evidence of this potential relationship. We searched PubMed, EMBASE, and the Cochrane Library up to September 2014 to retrieve relevant articles. Prospective cohort studies were included if the relative risks (RRs) or hazard ratios and 95% confidence intervals (CIs) for gastric cancer according to coffee consumption were reported. Fixed- or random-effects models were used based on heterogeneity. The search yielded 13 eligible cohort studies of 3484 incident gastric cancer patients from among 1,324,559 participants. A significantly increased risk was found between gastric cardia cancer and coffee consumption (RR = 1.50, 95% CI: 1.09-2.07). Compared with Europeans (RR = 1.12, 95% CI: 0.86-1.46) and Asians (RR = 0.96, 95% CI: 0.72-1.27), Americans (RR = 1.36, 95% CI: 1.06-1.74) demonstrated a significantly positive association. However, the significant differences of the pooled results vanished after adjusting for smoking or body mass index. Our meta-analysis results suggest that a high level of coffee consumption is a risk factor for gastric cancer. However, these results should not be overinterpreted because residual confounding effects of other factors could exist. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/26710312/Coffee_consumption_and_the_risk_of_incident_gastric_cancer__A_meta_analysis_of_prospective_cohort_studies_ DB - PRIME DP - Unbound Medicine ER -