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Recent Developments in the Classification, Evaluation, Pathophysiology, and Management of Scleroderma Renal Crisis.
Curr Rheumatol Rep. 2016 Jan; 18(1):5.CR

Abstract

Scleroderma renal crisis (SRC) is an uncommon complication of systemic sclerosis. Despite the advent of angiotensin-converting inhibitor therapy, SRC remains a life-threatening complication. Recent studies have contributed to a better understanding of SRC, but much remains unknown regarding its pathophysiology, risk factors, and optimal management. Genetic studies provide evidence that immune dysregulation might be a contributing factor, providing hope that further research in this direction might illuminate pathogenesis and provide novel predictors for this complication.

Authors+Show Affiliations

Department of Medicine, Division of Nephrology, Northwestern University, Feinberg School of Medicine, 710 North Fairbanks Court-Suite 4500, Chicago, IL, 60611, USA. c-ghossein@northwestern.edu.Department of Medicine, Northwestern University, Feinberg School of Medicine, 240 E Huron Street McGaw Pavilion Rheumatology M300, Chicago, IL, 60611, USA. j-varga@northwestern.edu. Department of Medicine, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, 240 E Huron Street McGaw Pavilion Rheumatology M300, Chicago, IL, 60611, USA. j-varga@northwestern.edu.Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, Suite 503B, Boston, MA, 02114, USA. AFENVES@mgh.harvard.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26711696

Citation

Ghossein, Cybele, et al. "Recent Developments in the Classification, Evaluation, Pathophysiology, and Management of Scleroderma Renal Crisis." Current Rheumatology Reports, vol. 18, no. 1, 2016, p. 5.
Ghossein C, Varga J, Fenves AZ. Recent Developments in the Classification, Evaluation, Pathophysiology, and Management of Scleroderma Renal Crisis. Curr Rheumatol Rep. 2016;18(1):5.
Ghossein, C., Varga, J., & Fenves, A. Z. (2016). Recent Developments in the Classification, Evaluation, Pathophysiology, and Management of Scleroderma Renal Crisis. Current Rheumatology Reports, 18(1), 5. https://doi.org/10.1007/s11926-015-0551-y
Ghossein C, Varga J, Fenves AZ. Recent Developments in the Classification, Evaluation, Pathophysiology, and Management of Scleroderma Renal Crisis. Curr Rheumatol Rep. 2016;18(1):5. PubMed PMID: 26711696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent Developments in the Classification, Evaluation, Pathophysiology, and Management of Scleroderma Renal Crisis. AU - Ghossein,Cybele, AU - Varga,John, AU - Fenves,Andrew Z, PY - 2015/12/30/entrez PY - 2015/12/30/pubmed PY - 2016/9/17/medline KW - Angiotensin-converting enzyme inhibitor (ACEI) KW - Diffuse cutaneous disease (dcSSc) KW - Immune dysregulation KW - Malignant hypertension KW - Renal biopsy KW - Scleroderma renal crisis (SRC) KW - Systemic sclerosis KW - Thrombotic microangiopathy SP - 5 EP - 5 JF - Current rheumatology reports JO - Curr Rheumatol Rep VL - 18 IS - 1 N2 - Scleroderma renal crisis (SRC) is an uncommon complication of systemic sclerosis. Despite the advent of angiotensin-converting inhibitor therapy, SRC remains a life-threatening complication. Recent studies have contributed to a better understanding of SRC, but much remains unknown regarding its pathophysiology, risk factors, and optimal management. Genetic studies provide evidence that immune dysregulation might be a contributing factor, providing hope that further research in this direction might illuminate pathogenesis and provide novel predictors for this complication. SN - 1534-6307 UR - https://www.unboundmedicine.com/medline/citation/26711696/Recent_Developments_in_the_Classification_Evaluation_Pathophysiology_and_Management_of_Scleroderma_Renal_Crisis_ L2 - https://dx.doi.org/10.1007/s11926-015-0551-y DB - PRIME DP - Unbound Medicine ER -