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Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose.
J Cardiovasc Comput Tomogr. 2016 Mar-Apr; 10(2):114-20.JC

Abstract

INTRODUCTION

Coronary computed tomographic angiography (CTA) can characterize coronary atherosclerotic plaque components as calcified and non-calcified. Quantitative measurements of coronary plaque burden by coronary CTA may play a role in serial studies to determine disease progression or response to medical therapies. The reproducibility from repeated assessment of such quantitative measurements from low-radiation dose coronary CTA has not been previously assessed.

PURPOSE

To evaluate the interscan, interobserver and intraobserver reproducibility for coronary plaque volume assessment using semi-automatic plaque analyses algorithm in low radiation dose coronary CTA.

METHODS

In 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days with a mean radiation dose of 0.7 mSv per coronary CTA, the interscan, interobserver and intraobserver reproducibility of coronary plaque assessment using validated software (AutoPlaq) were evaluated.

RESULTS

Interscan, interobserver and intraobserver agreement for non-calcified and calcified plaque volumes were excellent (Spearman rho 0.87-0.99). Interscan mean percentage difference in non-calcified and calcified plaque volumes were 0.1% (p = 0.8) and 1.9% (p = 0.19) with limits of agreement of ±11% and ±48.5%; per inter- and intraobserver mean percentage differences were 0.1% (p = 0.25) and 0.3% (p = 0.001), and 0.3% (p = 0.33) and 0.4% (p = 0.59) with limits of agreement of ±7% and ±32.9%, and ±6.6% and ±32.1%, respectively.

CONCLUSION

A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures.

Authors+Show Affiliations

Aarhus University Hospital, Department of Cardiology, Denmark; Lillebaelt Hospital Vejle, Department of Cardiology, Denmark; Odense University Hospital, Department of Cardiology, Denmark. Electronic address: kristianovrehus@hotmail.com.Erlangen University Hospital, Germany.Erlangen University Hospital, Germany.Erlangen University Hospital, Germany.Cedars Sinai Medical Center, Los Angeles, USA.Cedars Sinai Medical Center, Los Angeles, USA.Cedars Sinai Medical Center, Los Angeles, USA.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

26712694

Citation

Øvrehus, Kristian Altern, et al. "Reproducibility of Semi-automatic Coronary Plaque Quantification in Coronary CT Angiography With sub-mSv Radiation Dose." Journal of Cardiovascular Computed Tomography, vol. 10, no. 2, 2016, pp. 114-20.
Øvrehus KA, Schuhbaeck A, Marwan M, et al. Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose. J Cardiovasc Comput Tomogr. 2016;10(2):114-20.
Øvrehus, K. A., Schuhbaeck, A., Marwan, M., Achenbach, S., Nørgaard, B. L., Bøtker, H. E., & Dey, D. (2016). Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose. Journal of Cardiovascular Computed Tomography, 10(2), 114-20. https://doi.org/10.1016/j.jcct.2015.11.003
Øvrehus KA, et al. Reproducibility of Semi-automatic Coronary Plaque Quantification in Coronary CT Angiography With sub-mSv Radiation Dose. J Cardiovasc Comput Tomogr. 2016 Mar-Apr;10(2):114-20. PubMed PMID: 26712694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose. AU - Øvrehus,Kristian Altern, AU - Schuhbaeck,Annika, AU - Marwan,Mohamed, AU - Achenbach,Stephan, AU - Nørgaard,Bjarne Linde, AU - Bøtker,Hans Erik, AU - Dey,Damini, Y1 - 2015/12/02/ PY - 2014/11/07/received PY - 2015/10/28/revised PY - 2015/11/12/accepted PY - 2015/12/30/entrez PY - 2015/12/30/pubmed PY - 2016/12/15/medline KW - Coronary CT angiography KW - Coronary artery disease KW - Coronary plaque imaging SP - 114 EP - 20 JF - Journal of cardiovascular computed tomography JO - J Cardiovasc Comput Tomogr VL - 10 IS - 2 N2 - INTRODUCTION: Coronary computed tomographic angiography (CTA) can characterize coronary atherosclerotic plaque components as calcified and non-calcified. Quantitative measurements of coronary plaque burden by coronary CTA may play a role in serial studies to determine disease progression or response to medical therapies. The reproducibility from repeated assessment of such quantitative measurements from low-radiation dose coronary CTA has not been previously assessed. PURPOSE: To evaluate the interscan, interobserver and intraobserver reproducibility for coronary plaque volume assessment using semi-automatic plaque analyses algorithm in low radiation dose coronary CTA. METHODS: In 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days with a mean radiation dose of 0.7 mSv per coronary CTA, the interscan, interobserver and intraobserver reproducibility of coronary plaque assessment using validated software (AutoPlaq) were evaluated. RESULTS: Interscan, interobserver and intraobserver agreement for non-calcified and calcified plaque volumes were excellent (Spearman rho 0.87-0.99). Interscan mean percentage difference in non-calcified and calcified plaque volumes were 0.1% (p = 0.8) and 1.9% (p = 0.19) with limits of agreement of ±11% and ±48.5%; per inter- and intraobserver mean percentage differences were 0.1% (p = 0.25) and 0.3% (p = 0.001), and 0.3% (p = 0.33) and 0.4% (p = 0.59) with limits of agreement of ±7% and ±32.9%, and ±6.6% and ±32.1%, respectively. CONCLUSION: A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures. SN - 1876-861X UR - https://www.unboundmedicine.com/medline/citation/26712694/Reproducibility_of_semi_automatic_coronary_plaque_quantification_in_coronary_CT_angiography_with_sub_mSv_radiation_dose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1934-5925(15)30017-4 DB - PRIME DP - Unbound Medicine ER -