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Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina.
Toxins (Basel). 2015 Dec 25; 8(1)T

Abstract

Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B. diporus, is widely distributed throughout the country, but principally found in the Northeast, the region with the highest rates of snakebites. The venom proteome of this medically relevant snake was unveiled using a venomic approach. It comprises toxins belonging to fourteen protein families, being dominated by PI- and PIII-SVMPs, PLA₂ molecules, BPP-like peptides, L-amino acid oxidase and serine proteinases. This toxin profile largely explains the characteristic pathophysiological effects of bothropic snakebites observed in patients envenomed by B. diporus. Antivenomic analysis of the SAB antivenom (Instituto Vital Brazil) against the venom of B. diporus showed that this pentabothropic antivenom efficiently recognized all the venom proteins and exhibited poor affinity towards the small peptide (BPPs and tripeptide inhibitors of PIII-SVMPs) components of the venom.

Authors+Show Affiliations

Facultad de Ciencias Exactas y Naturales y Agrimensura, Universidad Nacional del Nordeste, Avenida Libertad 5470, 3400 Corrientes, Argentina. claudiacarolinagay@yahoo.com.ar.Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010 Valencia, Spain. libia.sanz@ibv.csic.es.Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010 Valencia, Spain. jcalvete@ibv.csic.es.Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010 Valencia, Spain. dpla@ibv.csic.es.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26712790

Citation

Gay, Carolina, et al. "Snake Venomics and Antivenomics of Bothrops Diporus, a Medically Important Pitviper in Northeastern Argentina." Toxins, vol. 8, no. 1, 2015.
Gay C, Sanz L, Calvete JJ, et al. Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina. Toxins (Basel). 2015;8(1).
Gay, C., Sanz, L., Calvete, J. J., & Pla, D. (2015). Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina. Toxins, 8(1). https://doi.org/10.3390/toxins8010009
Gay C, et al. Snake Venomics and Antivenomics of Bothrops Diporus, a Medically Important Pitviper in Northeastern Argentina. Toxins (Basel). 2015 Dec 25;8(1) PubMed PMID: 26712790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina. AU - Gay,Carolina, AU - Sanz,Libia, AU - Calvete,Juan J, AU - Pla,Davinia, Y1 - 2015/12/25/ PY - 2015/11/17/received PY - 2015/12/17/revised PY - 2015/12/17/accepted PY - 2015/12/30/entrez PY - 2015/12/30/pubmed PY - 2016/10/7/medline KW - Bothrops diporus venom KW - antivenomics KW - mass spectrometry KW - snake venom proteome KW - venomics JF - Toxins JO - Toxins (Basel) VL - 8 IS - 1 N2 - Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B. diporus, is widely distributed throughout the country, but principally found in the Northeast, the region with the highest rates of snakebites. The venom proteome of this medically relevant snake was unveiled using a venomic approach. It comprises toxins belonging to fourteen protein families, being dominated by PI- and PIII-SVMPs, PLA₂ molecules, BPP-like peptides, L-amino acid oxidase and serine proteinases. This toxin profile largely explains the characteristic pathophysiological effects of bothropic snakebites observed in patients envenomed by B. diporus. Antivenomic analysis of the SAB antivenom (Instituto Vital Brazil) against the venom of B. diporus showed that this pentabothropic antivenom efficiently recognized all the venom proteins and exhibited poor affinity towards the small peptide (BPPs and tripeptide inhibitors of PIII-SVMPs) components of the venom. SN - 2072-6651 UR - https://www.unboundmedicine.com/medline/citation/26712790/Snake_Venomics_and_Antivenomics_of_Bothrops_diporus_a_Medically_Important_Pitviper_in_Northeastern_Argentina_ L2 - https://www.mdpi.com/resolver?pii=toxins8010009 DB - PRIME DP - Unbound Medicine ER -