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Renal Complications and Their Prognosis in Korean Patients with Middle East Respiratory Syndrome-Coronavirus from the Central MERS-CoV Designated Hospital.
J Korean Med Sci. 2015 Dec; 30(12):1807-14.JK

Abstract

Some cases of Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) infection presented renal function impairment after the first MERS-CoV patient died of progressive respiratory and renal failure. Thus, MERS-CoV may include kidney tropism. However, reports about the natural courses of MERS-CoV infection in terms of renal complications are scarce. We examined 30 MERS-CoV patients admitted to National Medical Center, Korea. We conducted a retrospective analysis of the serum creatinine (SCr), estimated glomerular filtration rate (eGFR), urine dipstick tests, urinary protein quantitation (ACR or PCR), and other clinical parameters in all patients. Two consecutive results of more than trace (or 1+) of albumin and blood on dipstick test occurred in 18 (60%) (12 [40%]) and 22 (73.3%) (19 [63.3%]) patients, respectively. Fifteen (50.0%) patients showed a random urine ACR or PCR more than 100 mg/g Cr. Eight (26.7%) patients showed acute kidney injury (AKI), and the mean and median durations to the occurrence of AKI from symptom onset were 18 and 16 days, respectively. Old age was associated with a higher occurrence of AKI in the univariate analysis (HR [95% CI]: 1.069 [1.013-1.128], P = 0.016) and remained a significant predictor of the occurrence of AKI after adjustment for comorbidities and the application of a mechanical ventilator. Diabetes, AKI, and the application of a continuous renal replacement therapy (CRRT) were risk factors for mortality in the univariate analysis (HR [95% CI]: diabetes; 10.133 [1.692-60.697], AKI; 12.744 [1.418-114.565], CRRT; 10.254 [1.626-64.666], respectively). Here, we report renal complications and their prognosis in 30 Korean patients with MERS-CoV.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, National Medical Center, Seoul, Korea.Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea.Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea.Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea.Center for Infectious Diseases, National Medical Center, Seoul, Korea.Center for Infectious Diseases, National Medical Center, Seoul, Korea.Center for Infectious Diseases, National Medical Center, Seoul, Korea.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26713056

Citation

Cha, Ran-Hui, et al. "Renal Complications and Their Prognosis in Korean Patients With Middle East Respiratory Syndrome-Coronavirus From the Central MERS-CoV Designated Hospital." Journal of Korean Medical Science, vol. 30, no. 12, 2015, pp. 1807-14.
Cha RH, Joh JS, Jeong I, et al. Renal Complications and Their Prognosis in Korean Patients with Middle East Respiratory Syndrome-Coronavirus from the Central MERS-CoV Designated Hospital. J Korean Med Sci. 2015;30(12):1807-14.
Cha, R. H., Joh, J. S., Jeong, I., Lee, J. Y., Shin, H. S., Kim, G., & Kim, Y. (2015). Renal Complications and Their Prognosis in Korean Patients with Middle East Respiratory Syndrome-Coronavirus from the Central MERS-CoV Designated Hospital. Journal of Korean Medical Science, 30(12), 1807-14. https://doi.org/10.3346/jkms.2015.30.12.1807
Cha RH, et al. Renal Complications and Their Prognosis in Korean Patients With Middle East Respiratory Syndrome-Coronavirus From the Central MERS-CoV Designated Hospital. J Korean Med Sci. 2015;30(12):1807-14. PubMed PMID: 26713056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal Complications and Their Prognosis in Korean Patients with Middle East Respiratory Syndrome-Coronavirus from the Central MERS-CoV Designated Hospital. AU - Cha,Ran-Hui, AU - Joh,Joon-Sung, AU - Jeong,Ina, AU - Lee,Ji Yeon, AU - Shin,Hyoung-Shik, AU - Kim,Gayeon, AU - Kim,Yeonjae, AU - ,, Y1 - 2015/11/30/ PY - 2015/10/26/received PY - 2015/11/06/accepted PY - 2015/12/30/entrez PY - 2015/12/30/pubmed PY - 2016/10/8/medline KW - East Respiratory Syndrome-Coronavirus KW - Middle KW - Prognosis KW - Renal Complication SP - 1807 EP - 14 JF - Journal of Korean medical science JO - J. Korean Med. Sci. VL - 30 IS - 12 N2 - Some cases of Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) infection presented renal function impairment after the first MERS-CoV patient died of progressive respiratory and renal failure. Thus, MERS-CoV may include kidney tropism. However, reports about the natural courses of MERS-CoV infection in terms of renal complications are scarce. We examined 30 MERS-CoV patients admitted to National Medical Center, Korea. We conducted a retrospective analysis of the serum creatinine (SCr), estimated glomerular filtration rate (eGFR), urine dipstick tests, urinary protein quantitation (ACR or PCR), and other clinical parameters in all patients. Two consecutive results of more than trace (or 1+) of albumin and blood on dipstick test occurred in 18 (60%) (12 [40%]) and 22 (73.3%) (19 [63.3%]) patients, respectively. Fifteen (50.0%) patients showed a random urine ACR or PCR more than 100 mg/g Cr. Eight (26.7%) patients showed acute kidney injury (AKI), and the mean and median durations to the occurrence of AKI from symptom onset were 18 and 16 days, respectively. Old age was associated with a higher occurrence of AKI in the univariate analysis (HR [95% CI]: 1.069 [1.013-1.128], P = 0.016) and remained a significant predictor of the occurrence of AKI after adjustment for comorbidities and the application of a mechanical ventilator. Diabetes, AKI, and the application of a continuous renal replacement therapy (CRRT) were risk factors for mortality in the univariate analysis (HR [95% CI]: diabetes; 10.133 [1.692-60.697], AKI; 12.744 [1.418-114.565], CRRT; 10.254 [1.626-64.666], respectively). Here, we report renal complications and their prognosis in 30 Korean patients with MERS-CoV. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/26713056/Renal_Complications_and_Their_Prognosis_in_Korean_Patients_with_Middle_East_Respiratory_Syndrome_Coronavirus_from_the_Central_MERS_CoV_Designated_Hospital_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2015.30.12.1807 DB - PRIME DP - Unbound Medicine ER -