Tags

Type your tag names separated by a space and hit enter

Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1.
J Korean Neurosurg Soc. 2015 Nov; 58(5):454-61.JK

Abstract

OBJECTIVE

In this study, we aimed to investigate the underlying ethiological factors in chiari malformation (CM) type-I (CMI) via performing volumetric and morphometric length-angle measurements.

METHODS

A total of 66 individuals [33 patients (20-65 years) with CMI and 33 control subjects] were included in this study. In sagittal MR images, tonsillar herniation length and concurrent anomalies were evaluated. Supratentorial, infratentorial, and total intracranial volumes were measured using Cavalieri method. Various cranial distances and angles were used to evaluate the platybasia and posterior cranial fossa (PCF) development.

RESULTS

Tonsillar herniation length was measured 9.09±3.39 mm below foramen magnum in CM group. Tonsillar herniation/concurrent syringomyelia, concavity/defect of clivus, herniation of bulbus and fourth ventricle, basilar invagination and craniovertebral junction abnormality rates were 30.3, 27, 18, 2, 3, and 3 percent, respectively. Absence of cisterna magna was encountered in 87.9% of the patients. Total, IT and ST volumes and distance between Chamberlain line and tip of dens axis, Klaus index, clivus length, distance between internal occipital protuberance and opisthion were significantly decreased in patient group. Also in patient group, it was found that Welcher basal angle/Boogard angle increased and tentorial slope angle decreased.

CONCLUSION

Mean cranial volume and length-angle measurement values significantly decreased and there was a congenital abnormality association in nearly 81.5 percent of the CM cases. As a result, it was concluded that CM ethiology can be attributed to multifactorial causes. Moreover, congenital defects can also give rise to this condition.

Authors+Show Affiliations

Department of Anatomy, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.Department of Anatomy, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.Department of Neurological Surgery, Faculty of Medicine, Balıkesir University, Balıkesir, Turkey.Department of Anatomy, Faculty of Medicine, Turgut Özal University, Ankara, Turkey.Department of Anatomy, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.Department of Radiology, Afyonkarahisar State Hospital, Afyon, Turkey.Department of Radiology, Faculty of Medicine, Ordu University, Ordu, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26713146

Citation

Alkoç, Ozan Alper, et al. "Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1." Journal of Korean Neurosurgical Society, vol. 58, no. 5, 2015, pp. 454-61.
Alkoç OA, Songur A, Eser O, et al. Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1. Journal of Korean Neurosurgical Society. 2015;58(5):454-61.
Alkoç, O. A., Songur, A., Eser, O., Toktas, M., Gönül, Y., Esi, E., & Haktanir, A. (2015). Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1. Journal of Korean Neurosurgical Society, 58(5), 454-61. https://doi.org/10.3340/jkns.2015.58.5.454
Alkoç OA, et al. Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1. Journal of Korean Neurosurgical Society. 2015;58(5):454-61. PubMed PMID: 26713146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1. AU - Alkoç,Ozan Alper, AU - Songur,Ahmet, AU - Eser,Olcay, AU - Toktas,Muhsin, AU - Gönül,Yücel, AU - Esi,Ertap, AU - Haktanir,Alpay, Y1 - 2015/11/30/ PY - 2015/02/12/received PY - 2015/08/07/revised PY - 2015/08/31/accepted PY - 2015/12/30/entrez PY - 2015/12/30/pubmed PY - 2015/12/30/medline KW - Cavalieri method KW - Chiari malformation KW - MRI KW - Morphometry SP - 454 EP - 61 JF - Journal of Korean Neurosurgical Society VL - 58 IS - 5 N2 - OBJECTIVE: In this study, we aimed to investigate the underlying ethiological factors in chiari malformation (CM) type-I (CMI) via performing volumetric and morphometric length-angle measurements. METHODS: A total of 66 individuals [33 patients (20-65 years) with CMI and 33 control subjects] were included in this study. In sagittal MR images, tonsillar herniation length and concurrent anomalies were evaluated. Supratentorial, infratentorial, and total intracranial volumes were measured using Cavalieri method. Various cranial distances and angles were used to evaluate the platybasia and posterior cranial fossa (PCF) development. RESULTS: Tonsillar herniation length was measured 9.09±3.39 mm below foramen magnum in CM group. Tonsillar herniation/concurrent syringomyelia, concavity/defect of clivus, herniation of bulbus and fourth ventricle, basilar invagination and craniovertebral junction abnormality rates were 30.3, 27, 18, 2, 3, and 3 percent, respectively. Absence of cisterna magna was encountered in 87.9% of the patients. Total, IT and ST volumes and distance between Chamberlain line and tip of dens axis, Klaus index, clivus length, distance between internal occipital protuberance and opisthion were significantly decreased in patient group. Also in patient group, it was found that Welcher basal angle/Boogard angle increased and tentorial slope angle decreased. CONCLUSION: Mean cranial volume and length-angle measurement values significantly decreased and there was a congenital abnormality association in nearly 81.5 percent of the CM cases. As a result, it was concluded that CM ethiology can be attributed to multifactorial causes. Moreover, congenital defects can also give rise to this condition. SN - 2005-3711 UR - https://www.unboundmedicine.com/medline/citation/26713146/Stereological_and_Morphometric_Analysis_of_MRI_Chiari_Malformation_Type_1_ L2 - http://jkns.or.kr/journal/view.php?doi=10.3340/jkns.2015.58.5.454 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.