Tags

Type your tag names separated by a space and hit enter

Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study.
Arthritis Care Res (Hoboken). 2016 08; 68(8):1135-42.AC

Abstract

OBJECTIVE

Cigarette smoking is shown to reduce serum urate. However, its impact on risk of gout is unknown. We prospectively examined the relationship between cigarette smoking and gout risk in this Asian cohort.

METHODS

We analyzed the data from the Singapore Chinese Health Study, a cohort of 63,257 Chinese ages 45-74 years at recruitment in 1993-1998. Information on cigarette smoking and other lifestyle factors was collected through in-person interviews at recruitment. This analysis included 53,213 participants who took part in either the first followup (1999-2004) and/or the second followup interviews (2006-2010). Cox proportional hazards models were used to assess the relationship between cigarette smoking and gout risk.

RESULTS

A total of 2,244 incident cases of physician-diagnosed gout were identified after a mean followup of 11.1 years. Among men, compared to never smokers, the risk of gout in current smokers was decreased by 27% (hazard ratio [HR] 0.73 [95% confidence interval (95% CI) 0.63-0.84]). This risk reduction was greater in lean male smokers (HR 0.69 [95% CI 0.57-0.83]) than overweight smokers (HR 0.87 [95% CI 0.67-1.13]) (P = 0.09 for interaction). This inverse association with smoking was rapidly attenuated to become null even in former smokers who had recently quit smoking. Conversely, there was no association between smoking and gout risk in women. In a companion cross-sectional study, current smokers had significantly lower levels of serum urate than former and never smokers, and this observation was present in men and not women.

CONCLUSION

Current smoking is associated with lower risk of gout in men in this Asian cohort.

Authors+Show Affiliations

National University of Singapore and National University Health System, Singapore.National University of Singapore and National University Health System, Singapore.University of Pittsburgh, Pittsburgh, Pennsylvania.National University of Singapore and National University Health System, Singapore.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26714165

Citation

Gee Teng, Gim, et al. "Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study." Arthritis Care & Research, vol. 68, no. 8, 2016, pp. 1135-42.
Gee Teng G, Pan A, Yuan JM, et al. Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study. Arthritis Care Res (Hoboken). 2016;68(8):1135-42.
Gee Teng, G., Pan, A., Yuan, J. M., & Koh, W. P. (2016). Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study. Arthritis Care & Research, 68(8), 1135-42. https://doi.org/10.1002/acr.22821
Gee Teng G, et al. Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study. Arthritis Care Res (Hoboken). 2016;68(8):1135-42. PubMed PMID: 26714165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study. AU - Gee Teng,Gim, AU - Pan,An, AU - Yuan,Jian-Min, AU - Koh,Woon-Puay, PY - 2015/05/27/received PY - 2015/12/03/revised PY - 2015/12/15/accepted PY - 2015/12/30/entrez PY - 2015/12/30/pubmed PY - 2017/7/20/medline SP - 1135 EP - 42 JF - Arthritis care & research JO - Arthritis Care Res (Hoboken) VL - 68 IS - 8 N2 - OBJECTIVE: Cigarette smoking is shown to reduce serum urate. However, its impact on risk of gout is unknown. We prospectively examined the relationship between cigarette smoking and gout risk in this Asian cohort. METHODS: We analyzed the data from the Singapore Chinese Health Study, a cohort of 63,257 Chinese ages 45-74 years at recruitment in 1993-1998. Information on cigarette smoking and other lifestyle factors was collected through in-person interviews at recruitment. This analysis included 53,213 participants who took part in either the first followup (1999-2004) and/or the second followup interviews (2006-2010). Cox proportional hazards models were used to assess the relationship between cigarette smoking and gout risk. RESULTS: A total of 2,244 incident cases of physician-diagnosed gout were identified after a mean followup of 11.1 years. Among men, compared to never smokers, the risk of gout in current smokers was decreased by 27% (hazard ratio [HR] 0.73 [95% confidence interval (95% CI) 0.63-0.84]). This risk reduction was greater in lean male smokers (HR 0.69 [95% CI 0.57-0.83]) than overweight smokers (HR 0.87 [95% CI 0.67-1.13]) (P = 0.09 for interaction). This inverse association with smoking was rapidly attenuated to become null even in former smokers who had recently quit smoking. Conversely, there was no association between smoking and gout risk in women. In a companion cross-sectional study, current smokers had significantly lower levels of serum urate than former and never smokers, and this observation was present in men and not women. CONCLUSION: Current smoking is associated with lower risk of gout in men in this Asian cohort. SN - 2151-4658 UR - https://www.unboundmedicine.com/medline/citation/26714165/Cigarette_Smoking_and_the_Risk_of_Incident_Gout_in_a_Prospective_Cohort_Study_ L2 - https://doi.org/10.1002/acr.22821 DB - PRIME DP - Unbound Medicine ER -