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Combined regimens of one year duration in the treatment of multibacillary leprosy--I. Combined regimens with rifampicin administered during one year.
Lepr Rev. 1989 Jun; 60(2):109-17.LR

Abstract

In 1981, 1982 and 1983, 216 multibacillary patients in Anjouan (Comores) and Burundi were treated for 8 weeks with daily rifampicin (600 mg) ethionamide (500 mg) and dapsone (100 mg) or clofazimine (100 mg) followed for 44 weeks by once weekly rifampicin (600 mg) and daily ethionamide (500 mg) and dapsone (100 mg) or clofazimine (100 mg). There were 109 previously untreated patients and 107 patients who had dapsone monotherapy, 16 of whom were infected with proven dapsone resistant Mycobacterium leprae. Clinical and bacteriological results were excellent but hepatotoxicity of this regimen remains a problem. No relapses were observed during a 2 to 6 years (mean: 4.29 years) follow-up period after the end of treatment (upper 95% confidence limit of 0.40 per 100 persons years). It is concluded that multibacillary leprosy can be successfully treated with a regimen of one year duration, but less toxic regimens, more easily applicable in the field, are necessary.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2671559

Citation

Pattyn, S R., et al. "Combined Regimens of One Year Duration in the Treatment of Multibacillary leprosy--I. Combined Regimens With Rifampicin Administered During One Year." Leprosy Review, vol. 60, no. 2, 1989, pp. 109-17.
Pattyn SR, Bourland J, Grillone S, et al. Combined regimens of one year duration in the treatment of multibacillary leprosy--I. Combined regimens with rifampicin administered during one year. Lepr Rev. 1989;60(2):109-17.
Pattyn, S. R., Bourland, J., Grillone, S., Groenen, G., & Ghys, P. (1989). Combined regimens of one year duration in the treatment of multibacillary leprosy--I. Combined regimens with rifampicin administered during one year. Leprosy Review, 60(2), 109-17.
Pattyn SR, et al. Combined Regimens of One Year Duration in the Treatment of Multibacillary leprosy--I. Combined Regimens With Rifampicin Administered During One Year. Lepr Rev. 1989;60(2):109-17. PubMed PMID: 2671559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined regimens of one year duration in the treatment of multibacillary leprosy--I. Combined regimens with rifampicin administered during one year. AU - Pattyn,S R, AU - Bourland,J, AU - Grillone,S, AU - Groenen,G, AU - Ghys,P, PY - 1989/6/1/pubmed PY - 1989/6/1/medline PY - 1989/6/1/entrez SP - 109 EP - 17 JF - Leprosy review JO - Lepr Rev VL - 60 IS - 2 N2 - In 1981, 1982 and 1983, 216 multibacillary patients in Anjouan (Comores) and Burundi were treated for 8 weeks with daily rifampicin (600 mg) ethionamide (500 mg) and dapsone (100 mg) or clofazimine (100 mg) followed for 44 weeks by once weekly rifampicin (600 mg) and daily ethionamide (500 mg) and dapsone (100 mg) or clofazimine (100 mg). There were 109 previously untreated patients and 107 patients who had dapsone monotherapy, 16 of whom were infected with proven dapsone resistant Mycobacterium leprae. Clinical and bacteriological results were excellent but hepatotoxicity of this regimen remains a problem. No relapses were observed during a 2 to 6 years (mean: 4.29 years) follow-up period after the end of treatment (upper 95% confidence limit of 0.40 per 100 persons years). It is concluded that multibacillary leprosy can be successfully treated with a regimen of one year duration, but less toxic regimens, more easily applicable in the field, are necessary. SN - 0305-7518 UR - https://www.unboundmedicine.com/medline/citation/2671559/Combined_regimens_of_one_year_duration_in_the_treatment_of_multibacillary_leprosy__I__Combined_regimens_with_rifampicin_administered_during_one_year_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -