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Combined regimens of one year duration in the treatment of multibacillary leprosy--II. Combined regimens with rifampicin administered during 6 months.
Lepr Rev. 1989 Jun; 60(2):118-23.LR

Abstract

From 1981 to 1983 all multibacillary patients presenting at the collaborating centres in Zaire and Rwanda were treated with one of the following regimens: 6 months supervised daily RMP 600 mg, ETH 500 mg and DDS 100 mg or CLO 100 mg followed by 6 months unsupervised daily DDS 100 mg or CLO 100 mg with ETH 500 mg added or not. These regimens gave rise to hepatotoxicity, reversal and erythema nodosum leprosum reactions as described previously. Bactericidal activity was excellent. Among the 289 patients in the trial, with a mean follow-up period of 3.88 years, no relapses were observed, with an upper 95% confidence limit of 0.35 per 100 person years. Because of the hepatotoxicity, alternative short-course therapies need to be tested.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2671560

Citation

Pattyn, S R., et al. "Combined Regimens of One Year Duration in the Treatment of Multibacillary leprosy--II. Combined Regimens With Rifampicin Administered During 6 Months." Leprosy Review, vol. 60, no. 2, 1989, pp. 118-23.
Pattyn SR, Groenen G, Janssens L, et al. Combined regimens of one year duration in the treatment of multibacillary leprosy--II. Combined regimens with rifampicin administered during 6 months. Lepr Rev. 1989;60(2):118-23.
Pattyn, S. R., Groenen, G., Janssens, L., Deverchin, J., & Ghys, P. (1989). Combined regimens of one year duration in the treatment of multibacillary leprosy--II. Combined regimens with rifampicin administered during 6 months. Leprosy Review, 60(2), 118-23.
Pattyn SR, et al. Combined Regimens of One Year Duration in the Treatment of Multibacillary leprosy--II. Combined Regimens With Rifampicin Administered During 6 Months. Lepr Rev. 1989;60(2):118-23. PubMed PMID: 2671560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined regimens of one year duration in the treatment of multibacillary leprosy--II. Combined regimens with rifampicin administered during 6 months. AU - Pattyn,S R, AU - Groenen,G, AU - Janssens,L, AU - Deverchin,J, AU - Ghys,P, PY - 1989/6/1/pubmed PY - 1989/6/1/medline PY - 1989/6/1/entrez SP - 118 EP - 23 JF - Leprosy review JO - Lepr Rev VL - 60 IS - 2 N2 - From 1981 to 1983 all multibacillary patients presenting at the collaborating centres in Zaire and Rwanda were treated with one of the following regimens: 6 months supervised daily RMP 600 mg, ETH 500 mg and DDS 100 mg or CLO 100 mg followed by 6 months unsupervised daily DDS 100 mg or CLO 100 mg with ETH 500 mg added or not. These regimens gave rise to hepatotoxicity, reversal and erythema nodosum leprosum reactions as described previously. Bactericidal activity was excellent. Among the 289 patients in the trial, with a mean follow-up period of 3.88 years, no relapses were observed, with an upper 95% confidence limit of 0.35 per 100 person years. Because of the hepatotoxicity, alternative short-course therapies need to be tested. SN - 0305-7518 UR - https://www.unboundmedicine.com/medline/citation/2671560/Combined_regimens_of_one_year_duration_in_the_treatment_of_multibacillary_leprosy__II__Combined_regimens_with_rifampicin_administered_during_6_months_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -