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Progression and outcomes of non-dialysis dependent chronic kidney disease patients: A single center longitudinal follow-up study.
Nephrology (Carlton). 2017 Jan; 22(1):25-34.N

Abstract

AIM

Despite increase global prevalence of End stage renal disease (ESRD) and subsequent need for renal replacement therapy (RRT), relatively little is known about disease progression and prognosis of earlier stages of CKD. Current study was conducted to examine rate of CKD progression, predictors of ESRD and death.

METHODS

A total 621 patients with estimated glomerular filtration rate (eGFR) of 15-59ml/min/1.73m2 (CKD stage 3 & 4) were selected and followed up for 10 years or until ESRD or death, whichever occurred first. Subjects who did not meet inclusion criteria were excluded (n=1474).

RESULTS

Annual cumulative decline in eGFR was 3.01±0.40 ml/min/1.73m2 . Overall disease progression was observed in 60% patients while 18% died. Among patients with CKD stage 3, 21% progressed to stage 4, 10% to stage 5ND (non-dialysis) and 31% to RRT while mortality was observed in 16% patients. On the other hand, 8% patients with CKD stage 4 progressed to stage 5ND, 31% to RRT and mortality was observed in 24% cases. Patients with CVD, higher systolic blood pressure, elevated phosphate levels, heavy proteinuria, microscopic hematuria and use of diuretics were more likely to develop ESRD. Advancing age, low eGFR, low systolic blood pressure, low hemoglobin and baseline diabetes were found to be significant predictors of mortality while being female reduced risk of mortality.

CONCLUSION

Our data suggest that, in this CKD cohort, patients were more likely to develop ESRD than death. Prime importance should be given to mild forms of CKD to retard and even reverse CKD progression.

Authors+Show Affiliations

Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Penang, 11800, Malaysia. Chronic Kidney Disease Resource Centre, School of Medical Sciences, Health Campus, University Sains Malaysia, Kubang Kerain, 16150, Kelantan, Malaysia.Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Penang, 11800, Malaysia.Chronic Kidney Disease Resource Centre, School of Medical Sciences, Health Campus, University Sains Malaysia, Kubang Kerain, 16150, Kelantan, Malaysia.Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Penang, 11800, Malaysia.Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Penang, 11800, Malaysia. Chronic Kidney Disease Resource Centre, School of Medical Sciences, Health Campus, University Sains Malaysia, Kubang Kerain, 16150, Kelantan, Malaysia.Department of Obstetrics and Gynecology, School of Medical Sciences, Health Campus University Sains Malaysia, Kubang Kerain, 16150, Kelantan, Malaysia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26718476

Citation

Khan, Yusra Habib, et al. "Progression and Outcomes of Non-dialysis Dependent Chronic Kidney Disease Patients: a Single Center Longitudinal Follow-up Study." Nephrology (Carlton, Vic.), vol. 22, no. 1, 2017, pp. 25-34.
Khan YH, Sarriff A, Adnan AS, et al. Progression and outcomes of non-dialysis dependent chronic kidney disease patients: A single center longitudinal follow-up study. Nephrology (Carlton). 2017;22(1):25-34.
Khan, Y. H., Sarriff, A., Adnan, A. S., Khan, A. H., Mallhi, T. H., & Jummaat, F. (2017). Progression and outcomes of non-dialysis dependent chronic kidney disease patients: A single center longitudinal follow-up study. Nephrology (Carlton, Vic.), 22(1), 25-34. https://doi.org/10.1111/nep.12713
Khan YH, et al. Progression and Outcomes of Non-dialysis Dependent Chronic Kidney Disease Patients: a Single Center Longitudinal Follow-up Study. Nephrology (Carlton). 2017;22(1):25-34. PubMed PMID: 26718476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progression and outcomes of non-dialysis dependent chronic kidney disease patients: A single center longitudinal follow-up study. AU - Khan,Yusra Habib, AU - Sarriff,Azmi, AU - Adnan,Azreen Syazril, AU - Khan,Amer Hayat, AU - Mallhi,Tauqeer Hussain, AU - Jummaat,Fauziah, PY - 2015/09/21/received PY - 2015/12/21/revised PY - 2015/12/26/accepted PY - 2016/1/1/pubmed PY - 2017/3/14/medline PY - 2016/1/1/entrez KW - chronic kidney disease KW - end stage renal disease KW - mortality KW - outcomes KW - progression SP - 25 EP - 34 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 22 IS - 1 N2 - AIM: Despite increase global prevalence of End stage renal disease (ESRD) and subsequent need for renal replacement therapy (RRT), relatively little is known about disease progression and prognosis of earlier stages of CKD. Current study was conducted to examine rate of CKD progression, predictors of ESRD and death. METHODS: A total 621 patients with estimated glomerular filtration rate (eGFR) of 15-59ml/min/1.73m2 (CKD stage 3 & 4) were selected and followed up for 10 years or until ESRD or death, whichever occurred first. Subjects who did not meet inclusion criteria were excluded (n=1474). RESULTS: Annual cumulative decline in eGFR was 3.01±0.40 ml/min/1.73m2 . Overall disease progression was observed in 60% patients while 18% died. Among patients with CKD stage 3, 21% progressed to stage 4, 10% to stage 5ND (non-dialysis) and 31% to RRT while mortality was observed in 16% patients. On the other hand, 8% patients with CKD stage 4 progressed to stage 5ND, 31% to RRT and mortality was observed in 24% cases. Patients with CVD, higher systolic blood pressure, elevated phosphate levels, heavy proteinuria, microscopic hematuria and use of diuretics were more likely to develop ESRD. Advancing age, low eGFR, low systolic blood pressure, low hemoglobin and baseline diabetes were found to be significant predictors of mortality while being female reduced risk of mortality. CONCLUSION: Our data suggest that, in this CKD cohort, patients were more likely to develop ESRD than death. Prime importance should be given to mild forms of CKD to retard and even reverse CKD progression. SN - 1440-1797 UR - https://www.unboundmedicine.com/medline/citation/26718476/Progression_and_outcomes_of_non_dialysis_dependent_chronic_kidney_disease_patients:_A_single_center_longitudinal_follow_up_study_ DB - PRIME DP - Unbound Medicine ER -