Tags

Type your tag names separated by a space and hit enter

Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.
J Virol. 2015 Dec 30; 90(6):3253-6.JV

Abstract

We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.

Authors+Show Affiliations

Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.Yunnan Institute of Endemic Diseases Control and Prevention, Dali, China.EcoHealth Alliance, New York, New York, USA.Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Singapore.Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China zlshi@wh.iov.cn.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26719272

Citation

Yang, Xing-Lou, et al. "Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus." Journal of Virology, vol. 90, no. 6, 2015, pp. 3253-6.
Yang XL, Hu B, Wang B, et al. Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. J Virol. 2015;90(6):3253-6.
Yang, X. L., Hu, B., Wang, B., Wang, M. N., Zhang, Q., Zhang, W., Wu, L. J., Ge, X. Y., Zhang, Y. Z., Daszak, P., Wang, L. F., & Shi, Z. L. (2015). Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. Journal of Virology, 90(6), 3253-6. https://doi.org/10.1128/JVI.02582-15
Yang XL, et al. Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. J Virol. 2015 Dec 30;90(6):3253-6. PubMed PMID: 26719272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. AU - Yang,Xing-Lou, AU - Hu,Ben, AU - Wang,Bo, AU - Wang,Mei-Niang, AU - Zhang,Qian, AU - Zhang,Wei, AU - Wu,Li-Jun, AU - Ge,Xing-Yi, AU - Zhang,Yun-Zhi, AU - Daszak,Peter, AU - Wang,Lin-Fa, AU - Shi,Zheng-Li, Y1 - 2015/12/30/ PY - 2015/10/13/received PY - 2015/12/21/accepted PY - 2016/1/1/entrez PY - 2016/1/1/pubmed PY - 2016/7/23/medline SP - 3253 EP - 6 JF - Journal of virology JO - J Virol VL - 90 IS - 6 N2 - We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans. SN - 1098-5514 UR - https://www.unboundmedicine.com/medline/citation/26719272/Isolation_and_Characterization_of_a_Novel_Bat_Coronavirus_Closely_Related_to_the_Direct_Progenitor_of_Severe_Acute_Respiratory_Syndrome_Coronavirus_ DB - PRIME DP - Unbound Medicine ER -